Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Federico Cerullo"'
Autor:
Pratik Rajendra Patil, A. Maxwell Burroughs, Mohit Misra, Federico Cerullo, Carlos Costas Insua, Hao-Chih Hung, Ivan Dikic, L. Aravind, Claudio A.P. Joazeiro
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113100- (2023)
Summary: In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted translation are modified with C-terminal polyalanine tails (“Ala-tails”) that function outside ribosomes to induce ubiquitylation by E3 ligases Pi
Externí odkaz:
https://doaj.org/article/9f8d3f9ceb3e41d9920d13ffab44615f
Publikováno v:
Mol Cell
Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides produced by interrupted translation. Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, wh
Autor:
Federico Cerullo, Sebastian Filbeck, Pratik Rajendra Patil, Hao-Chih Hung, Haifei Xu, Julia Vornberger, Florian W. Hofer, Jaro Schmitt, Guenter Kramer, Bernd Bukau, Kay Hofmann, Stefan Pfeffer, Claudio A. P. Joazeiro
Publikováno v:
Nature
Autor:
Claudio A. P. Joazeiro, George Tsaprailis, Stefan Pfeffer, Sebastian Filbeck, Helge Paternoga, Federico Cerullo
Publikováno v:
Molecular Cell. 81:104-114.e6
Aborted translation produces large ribosomal subunits obstructed with tRNA-linked nascent chains, which are substrates of ribosome-associated quality control (RQC). Bacterial RqcH, a widely conserved RQC factor, senses the obstruction and recruits tR