Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Federico Carafoli"'
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69833 (2013)
The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain
Externí odkaz:
https://doaj.org/article/9d1d9f11f659498bb0ecce99ea3115f0
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42473 (2012)
The heterotrimeric laminins are a defining component of basement membranes and essential for tissue formation and function in all animals. The three short arms of the cross-shaped laminin molecule are composed of one chain each and their tips mediate
Externí odkaz:
https://doaj.org/article/a94702e75eca4a868adae879af45bdde
Autor:
Erhard Hohenester, Federico Carafoli
Publikováno v:
Biochimica et Biophysica Acta
The discoidin domain receptors, DDR1 and DDR2, are two closely related receptor tyrosine kinases that are activated by triple-helical collagen in a slow and sustained manner. The DDRs have important roles in embryo development and their dysregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbc82ac1aee3ad241b8b05675161d49
Publikováno v:
EMBO Reports
Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region Laminin polymers are a key component of all basement membranes. The first crystal structure of a laminin amino-terminal domain identifies a conser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e826b4f4f28d964a0e4b41e061fbdd0
http://europepmc.org/articles/PMC3059903
http://europepmc.org/articles/PMC3059903
Publikováno v:
The Journal of Biological Chemistry
Laminins are large heterotrimeric glycoproteins with many essential functions in basement membrane assembly and function. Cell adhesion to laminins is mediated by a tandem of five laminin G-like (LG) domains at the C terminus of the alpha chain. Inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b20d2297e8a56072a2bcacf20936464
http://europepmc.org/articles/PMC2755686
http://europepmc.org/articles/PMC2755686
Autor:
Marc Kvansakul, Stavros Stathopoulos, Birgit Leitinger, Erhard Hohenester, Federico Carafoli, Antonios D. Konitsiotis, Richard W. Farndale, Dominique Bihan
Publikováno v:
Structure(London, England:1993)
Summary The discoidin domain receptors, DDR1 and DDR2, are widely expressed receptor tyrosine kinases that are activated by triple-helical collagen. They control important aspects of cell behavior and are dysregulated in several human diseases. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4ba93f99ed575706a9f838e5ec7e8c
http://europepmc.org/articles/PMC2807035
http://europepmc.org/articles/PMC2807035
Publikováno v:
Journal of Molecular Biology
Activation of the fibroblast growth factor receptor (FGFR) by neural cell adhesion molecule (NCAM) is essential for NCAM-mediated neurite outgrowth. Previous peptide studies have identified two regions in the fibronectin type 3 (FN3)-like domains of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052779eb64f41f85e25bff76534e6ded
https://doi.org/10.1016/j.jmb.2008.01.030
https://doi.org/10.1016/j.jmb.2008.01.030
Publikováno v:
FEBS Journal. 272:5799-5807
Hepatocyte growth factor like/macrophage stimulating protein (HGFl/MSP) and hepatocyte growth factor/scatter factor (HGF/SF) define a distinct family of vertebrate-specific growth factors structurally related to the blood proteinase precursor plasmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12324b26f5a397c0c34bbc89389594b
https://doi.org/10.1111/j.1742-4658.2005.04968.x
https://doi.org/10.1111/j.1742-4658.2005.04968.x
Autor:
Dominique Bihan, Erhard Hohenester, Szymon W. Manka, Hideaki Nagase, Gillian Murphy, Robert Visse, Federico Carafoli, Richard W. Farndale, Jan J. Enghild, Nicolas Raynal
Publikováno v:
Manka, S W, Carafoli, F, Visse, R, Bihan, D, Raynal, N, Farndale, R W, Murphy, G, Enghild, J J, Hohenester, E & Nagase, H 2012, ' Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 31, pp. 12461-12466 . https://doi.org/10.1073/pnas.1204991109
Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and cleave the collagen triple helix is not fully understood. Here, we report temperature-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd97b9aaeb37311b646a672ec89a833
http://hdl.handle.net/10044/1/15515
http://hdl.handle.net/10044/1/15515
Autor:
Birgit Leitinger, Federico Carafoli, Kazushige Shiraishi, Mira Anguelova Pecheva, Ruodan Nan, Lai Yi Chan, Marie Cathrin Mayer, Erhard Hohenester
Publikováno v:
Structure(London, England:1993)
Summary The discoidin domain receptors, DDR1 and DDR2, are constitutively dimeric receptor tyrosine kinases that are activated by triple-helical collagen. Aberrant DDR signaling contributes to several human pathologies, including many cancers. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16be912d729c4d3e668285a260c20bda
https://pubmed.ncbi.nlm.nih.gov/22483103
https://pubmed.ncbi.nlm.nih.gov/22483103