Výsledky vyhledávání - "Federico Andreoli"

Akademický článek

A Personalized Approach for Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries

Autor: Leonardo De Luca, Federico Andreoli, Raffaella Mistrulli, Giulia Mattaroccia, Gianmarco Gargano, Domenico Gabrielli

Publikováno v: Reviews in Cardiovascular Medicine, Vol 25, Iss 2, p 47 (2024)

Myocardial infarction with non-obstructive coronary arteries (MINOCA) includes coronary embolism, dissection, spasm and microvascular dysfunction, as well as plaque rupture or erosion (causing

Externí odkaz: https://doaj.org/article/f81ffc868f9c4ae2ba00125aca07880e

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Akademický článek

Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes

Autor: Federico Andreoli, Alberto Del Rio

Publikováno v: Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 358-365 (2015)

Growing evidences show that epigenetic mechanisms play crucial roles in the genesis and progression of many physiopathological processes. As a result, research in epigenetic grew at a fast pace in the last decade. In particular, the study of histone

Externí odkaz: https://doaj.org/article/dbfd14829196477caeba17b9c1402d5d

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Akademický článek

3-(2-Aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione as an Ecofriendly Sulphur Transfer Agent to Prepare Alkanethiols in High Yield and High Purity

Autor: Federico Andreoli, Mohammed Amine Mehdid, Christian Roussel, Ayada Djafri

Publikováno v: Molecules, Vol 14, Iss 11, Pp 4634-4643 (2009)

A new process is described for preparing very pure linear alkanethiols and linear α,ω-alkanedithiols using a sequential alkylation of the title compound, followed by a ring closure to quantitatively give the corresponding 3-methyl[1,3]thiazolo[3,2-

Externí odkaz: https://doaj.org/article/80f3e0973a7441b299c397c84c9e6f80

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Akademický článek

New Route to 3-Alkylthiazolo[3,2-a]benzimidazole Derivatives

Autor: Nicolas Vanthuyne, Maria Hristova, Mihaela Roman, Federico Andreoli, Christian Roussel

Publikováno v: Molecules, Vol 10, Iss 2, Pp 327-333 (2005)

3-Alkyl-thiazolo[3,2-a]benzimidazole derivatives are obtained in high yieldsvia the corresponding 4-alkyl-N-3-(2-aminophenyl)-thiazoline-2-thiones which are easilyprepared from 1,2-diaminobenzene, CS2 and halogenoketones. This new route comparesadvan

Externí odkaz: https://doaj.org/article/218ad74367d8451d9aa7052ab142881c

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Physicochemical modifications of histones and their impact on epigenomics

Autor: Federico Andreoli, Alberto Del Rio

Publikováno v: Drug discovery today (2014). doi:10.1016/j.drudis.2014.05.005
info:cnr-pdr/source/autori:Andreoli, Federico; Del Rio, Alberto Del/titolo:Physicochemical modifications of histones and their impact on epigenomics/doi:10.1016%2Fj.drudis.2014.05.005/rivista:Drug discovery today/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume

The study of histone post-translational modifications (PTMs) has made extraordinary progress over the past few years and many epigenetic modifications have been identified and found to be associated with fundamental biological processes and pathologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcdcaf5016c978944901aecaa9a70a3
https://doi.org/10.1016/j.drudis.2014.05.005

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Modulation of Epigenetic Targets for Anticancer Therapy: Clinicopathological Relevance, Structural Data and Drug Discovery Perspectives

Autor: Federico Andreoli, Arménio Jorge Moura Barbosa, Alberto Del Rio, Marco Daniele Parenti

Publikováno v: Current Pharmaceutical Design

Research on cancer epigenetics has flourished in the last decade. Nevertheless growing evidence point on the importance to understand the mechanisms by which epigenetic changes regulate the genesis and progression of cancer growth. Several epigenetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7143fc7b8b1d1b6e2440bf11198bff66
https://doi.org/10.2174/1381612811306040578

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Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: synthesis and biological evaluation

Autor: Christian Roussel, Mohammed Amine Mehdid, Federico Andreoli, Jean Dessolin, Nicolas Vanthuyne, Jean-Louis Kraus, Abdallah Larbi Doukara

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, 28 (1), pp.153-162. ⟨10.3109/14756366.2011.642375⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2011, 28 (1), pp.153-162. ⟨10.3109/14756366.2011.642375⟩

We report the synthesis and the β-site amyloid precursor protein cleaving enzyme-1 inhibitory properties of novel phenyl(thio)ureas bearing 2-(thio)oxothiazoline derivatives. A library of analogues was prepared according to specific synthetic scheme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2897ae57ca833d9729e0cdfcf9890dd1
https://doi.org/10.3109/14756366.2011.642375

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ChemInform Abstract: Access to N-Thioalkenyl and N-(o-Thio)aryl-benzimidazol-2-ones by Ring Opening of Thiazolobenzimidazolium and Benzimidazobenzothiazolium Salts and C-O Bond Cleavage of an Alkoxide

Autor: Fabien Coppola, Daniel Farran, Federico Andreoli, Nicolas Vanthuyne, Radia Kaid-Slimane, Christian Roussel

Publikováno v: ChemInform. 46

We report herein the synthesis of highly functionalized 1,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo[2,1-b][1,3]benzothiazol-6-ium salts and an unusual C-O bond cleavage of an alkoxide. A larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29c92fad89b61fab9c9e10da67315acd
https://doi.org/10.1002/chin.201531178

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Access to N-Thioalkenyl and N-(o-Thio)aryl-benzimidazol-2-ones by Ring Opening of Thiazolobenzimidazolium and Benzimidazobenzothiazolium Salts and C-O Bond Cleavage of an Alkoxide

Autor: Radia Kaid-Slimane, Federico Andreoli, Fabien Coppola, Nicolas Vanthuyne, Christian Roussel, Daniel Farran

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (6), pp.3233-3241. ⟨10.1021/acs.joc.5b00221⟩
Journal of Organic Chemistry, 2015, 80 (6), pp.3233-3241. ⟨10.1021/acs.joc.5b00221⟩

International audience; We report herein the synthesis of highly functionalized 1,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo[2,1-b][1,3]benzothiazol-6-ium salts and an unusual C-O bond cleavag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7d446c2bc705b4dd94292e4c55f6bc
https://hal.archives-ouvertes.fr/hal-01462224

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Metathetic sulfur transfer mediated by N-(2-aminophenyl)-4-methyl-thiazolin-2-thione derivatives. Part III: An alkylthiol- and thioacid-free route to diversely substituted S-alkyl thioesters

Autor: Andrea Buettner, Christian Roussel, Michel Giorgi, Nicolas Vanthuyne, Johannes Niebler, Federico Andreoli, Ayada Djafri, Mohammed Amine Mehdid, Daniel Farran

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2013, 69 (24), pp.4994-5001. ⟨10.1016/j.tet.2013.04.013⟩
Tetrahedron, 2013, 69 (24), pp.4994-5001. ⟨10.1016/j.tet.2013.04.013⟩

A metal free synthesis of S-alkyl thioesters, which does not involve alkylthiol or thiocarboxylic acid as sulfur source is disclosed. The process involves first an acylation at the nitrogen of the readily available N(2-aminophenyl)-4-methyl-thiazolin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3945987ee56e4d96e93958f736eb7b4
https://hal.archives-ouvertes.fr/hal-01684983

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