Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Federico Da Settimo"'
Autor:
Silvia Salerno, Monica Viviano, Emma Baglini, Valeria Poggetti, Doralice Giorgini, Jacopo Castagnoli, Elisabetta Barresi, Sabrina Castellano, Federico Da Settimo, Sabrina Taliani
Publikováno v:
Molecules, Vol 29, Iss 17, p 4212 (2024)
The translocator protein (TSPO) is predominately localized on the outer mitochondrial membrane in steroidogenic cells. In the brain, TSPO expression, low under normal conditions, results upregulated in response to glial cell activation, that occurs i
Externí odkaz:
https://doaj.org/article/d2ddf4396b5040eaa662e86ad6c54d30
Autor:
Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Jacopo Castagnoli, Doralice Giorgini, Silvia Salerno, Sabrina Taliani, Federico Da Settimo
Publikováno v:
Molecules, Vol 29, Iss 9, p 2127 (2024)
Neurodegeneration is a gradual decay process leading to the depletion of neurons in both the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions and the deterioration of brain functions, alongside a decline in motor
Externí odkaz:
https://doaj.org/article/e5aa4688eae348db9df1fcf72e123256
Autor:
Valentina Citi, Elisabetta Barresi, Eugenia Piragine, Jacopo Spezzini, Lara Testai, Federico Da Settimo, Alma Martelli, Sabrina Taliani, Vincenzo Calderone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16131 (2023)
Metformin (Met) is the first-line therapy in type 2 diabetes mellitus but, in last few years, it has also been evaluated as anti-cancer agent. Several pathways, such as AMPK or PI3K/Akt/mTOR, are likely to be involved in the anti-cancer Met activity.
Externí odkaz:
https://doaj.org/article/f3e934f39bfe4b418e6212127fc5e1ae
Autor:
Elisabetta Barresi, Marco Robello, Emma Baglini, Valeria Poggetti, Monica Viviano, Silvia Salerno, Federico Da Settimo, Sabrina Taliani
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 997 (2023)
In recent years, indolylglyoxylamide-based derivatives have received much attention due to their application in drug design and discovery, leading to the development of a wide array of compounds that have shown a variety of pharmacological activities
Externí odkaz:
https://doaj.org/article/3d5648265e164b6a94a4793759d4bbf5
Autor:
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Federico Da Settimo, Sabrina Taliani
Publikováno v:
Molecules, Vol 28, Iss 6, p 2587 (2023)
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical resection of the tumor, radiotherapy, and adjuvant chemotherapy with temozol
Externí odkaz:
https://doaj.org/article/a97b63019ee949dca15bd2a06d162359
Autor:
Elisabetta Barresi, Chiara Giacomelli, Laura Marchetti, Emma Baglini, Silvia Salerno, Giovanni Greco, Federico Da Settimo, Claudia Martini, Maria Letizia Trincavelli, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 287-295 (2021)
Small-molecules acting as positive allosteric modulators (PAMs) of the A2B adenosine receptor (A2B AR) could potentially represent a novel therapeutic strategy for pathological conditions characterised by altered bone homeostasis, including osteoporo
Externí odkaz:
https://doaj.org/article/dc4306897e52490da107451f312d9af8
Autor:
Elisabetta Barresi, Rahul Ravichandran, Lorenzo Germelli, Andrea Angeli, Emma Baglini, Silvia Salerno, Anna Maria Marini, Barbara Costa, Eleonora Da Pozzo, Claudia Martini, Federico Da Settimo, Claudiu Supuran, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1783-1797 (2021)
Carbonic Anhydrase Activators (CAAs) could represent a novel approach for the treatment of Alzheimer’s disease, ageing, and other conditions that require remedial achievement of spatial learning and memory therapy. Within a research project aimed a
Externí odkaz:
https://doaj.org/article/61803acb569c43b59486f5dce895777a
Autor:
Emma Baglini, Rahul Ravichandran, Emanuela Berrino, Silvia Salerno, Elisabetta Barresi, Anna Maria Marini, Monica Viviano, Sabrina Castellano, Federico Da Settimo, Claudiu T. Supuran, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1874-1883 (2021)
A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. O
Externí odkaz:
https://doaj.org/article/88031813ab9443118c310ad8a0e3ccdb
Autor:
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Sabrina Taliani, Federico Da Settimo
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2932 (2022)
Topoisomerase (Topo) inhibitors have long been known as clinically effective drugs, while G-quadruplex (G4)-targeting compounds are emerging as a promising new strategy to target tumor cells and could support personalized treatment approaches in the
Externí odkaz:
https://doaj.org/article/d4f7d56bb4ab403faf689e82da92841f
Autor:
Francesco Balestri, Marinella De Leo, Carlo Sorce, Mario Cappiello, Luca Quattrini, Roberta Moschini, Carlotta Pineschi, Alessandra Braca, Concettina La Motta, Federico Da Settimo, Antonella Del-Corso, Umberto Mura
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 350-360 (2019)
Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1). S
Externí odkaz:
https://doaj.org/article/ced34592d3214c6484a2359c6f64bf53