Association between long term exposure to particulate matter and incident hypertension in Spain

Autor: Viyey Doulatram-Gamgaram, Sergio Valdés, Cristina Maldonado-Araque, Ana Lago-Sampedro, Rocío Badía-Guillén, Eva García-Escobar, Sara García-Serrano, Marta García-Vivanco, Juan Luis Garrido, Mark Richard Theobald, Victoria Gil, Fernando Martín-Llorente, Alfonso Calle-Pascual, Elena Bordiu, Luis Castaño, Elías Delgado, Josep Franch-Nadal, F. Javier Chaves, Eduard Montanya, José Luis Galán-García, Gabriel Aguilera-Venegas, Federico Soriguer, Gemma Rojo-Martínez

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract Exposure to air particulate matter has been linked with hypertension and blood pressure levels. The metabolic risks of air pollution could vary according to the specific characteristics of each area, and has not been sufficiently evaluated i

Externí odkaz: https://doaj.org/article/d3e50b39ca0243798b1abf0ffee61555

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Autor: Richard A. Jensen, Denis Rybin, Jaakko Tuomilehto, Reedik Mägi, Inga Prokopenko, Jeffrey R. O'Connell, Marcus E. Kleber, Han Chen, Geoffrey A. Walford, Allan Linnenberg, Anke Tönjes, Francis S. Collins, Sonsoles Morcillo, Gemma Rojo-Martínez, Kenneth Rice, Jose C. Florez, Leif Groop, Manuel Serrano-Ríos, Josée Dupuis, Alisa K. Manning, Peter Kovacs, Torben Jørgensen, Graciela E. Delgado, Alena Stančáková, Hans-Ulrich Häring, Claudia Langenberg, Joshua P. Lewis, Norbert Stefan, Markku Laakso, Torben Hansen, Bruce M. Psaty, Jian'an Luan, Michael Stumvoll, Mark O. Goodarzi, Robert A. Scott, Oluf Pedersen, Ching-Ti Liu, Michael N. Weedon, Michael Boehnke, Ulf Smith, David S. Siscovick, Aaron Leong, Weijia Xie, James B. Meigs, Claes Landenvall, Anne U. Jackson, Joseph M. Zmuda, Mary L. Biggs, Jerome I. Rotter, Federico Soriguer, Winfried März, Zhongyang Zhang, May E. Montasser, Arturo Corbatón-Anchuelo, J M Gómez-Zumaquero, Günther Silbernagel, Kristine Færch, Karen L. Mohlke, Heikki A. Koistinen, Yii-Der Ida Chen, Jaeyoung Hong, Gracia María Martín-Núñez, María Teresa Martínez-Larrad, Emil V. R. Appel, Niels Grarup, Harald Staiger, Johanna Kuusisto, Lars Lind, Nicholas J. Wareham, Andreas Fritsche, Stefan Gustafsson, Andrew P. Morris, Richard N. Bergman, Mark Walker, Cecilia M. Lindgren, Erik Ingelsson, Jorge R. Kizer, Timothy M. Frayling, Fausto Machicao

Publikováno v: Diabetes
Walford, G A, Gustafsson, S, Rybin, D, Stančáková, A, Chen, H, Liu, C-T, Hong, J, Jensen, R A, Rice, K, Morris, A P, Mägi, R, Tönjes, A, Prokopenko, I, Kleber, M E, Delgado, G, Silbernagel, G, Jackson, A U, Appel, E V, Grarup, N, Lewis, J P, Montasser, M E, Landenvall, C, Staiger, H, Luan, J, Frayling, T M, Weedon, M N, Xie, W, Morcillo, S, Martínez-Larrad, M T, Biggs, M L, Ida Chen, Y-D, Corbaton-Anchuelo, A, Færch, K, Zumaquero, J M, Goodarzi, M O, Kizer, J, Koistinen, H A, Leong, A, Lind, L, Lindgren, C, Machicao, F, Manning, A K, Martín-Núñez, G M, Rojo-Martínez, G, Rotter, J I, Siscovick, D S, Zmuda, J M, Zhang, Z, Serrano-Rios, M, Smith, U, Soriguer, F, Hansen, T, Jørgensen, T J, Linnenberg, A, Pedersen, O, Walker, M, Langenberg, C, Scott, R A, Wareham, N J, Fritsche, A, Häring, H-U, Stefan, N, Groop, L, O'Connell, J R, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, März, W, Kovacs, P, Stumvoll, M, Psaty, B M, Kuusisto, J, Laakso, M, Meigs, J B, Dupuis, J, Ingelsson, E & Florez, J C 2016, ' Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci ', Diabetes, vol. 65, no. 10, pp. 3200-3211 . https://doi.org/10.2337/db16-0199
DIABETES

Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb835e572112710c128ad103623be68

Low Physical Activity and Its Association with Diabetes and Other Cardiovascular Risk Factors: A Nationwide, Population-Based Study.

Autor: Laura Brugnara, Serafín Murillo, Anna Novials, Gemma Rojo-Martínez, Federico Soriguer, Albert Goday, Alfonso Calle-Pascual, Luis Castaño, Sonia Gaztambide, Sergio Valdés, Josep Franch, Conxa Castell, Joan Vendrell, Roser Casamitjana, Anna Bosch-Comas, Elena Bordiú, Rafael Carmena, Miguel Catalá, Elias Delgado, Juan Girbés, Alfonso López-Alba, Maria Teresa Martínez-Larrad, Edelmiro Menéndez, Inmaculada Mora-Peces, Gemma Pascual-Manich, Manuel Serrano-Ríos, Ramon Gomis, Emilio Ortega

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160959 (2016)

Low physical activity (PA), or sedentary lifestyle, is associated with the development of several chronic diseases. We aimed to investigate current prevalence of sedentariness and its association with diabetes and other cardiovascular risk factors. P

Externí odkaz: https://doaj.org/article/78c68075a59c4c1ea119cc95181883be

Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study

Autor: Sergio Valdés, Francisco J. Tinahones, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Teresa María Linares-Pineda, Sonsoles Morcillo, Gemma Rojo-Martínez, Federico Soriguer, Carolina Gutiérrez-Repiso

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10417, p 10417 (2021)

Background: Identifying those parameters that could potentially predict the deterioration of metabolically healthy phenotype is a matter of debate. In this field, epigenetics, in particular DNA methylation deserves special attention. Results: The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c65c084b32f30b0d6b4a6b93fe56cb3

Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Autor: I. M. Urrutia-Etxebarria, Gabriel Aguilera-Venegas, T González-Frutos, Juan Girbés, Joan Vendrell, P. Ocón, Emilio Ortega, Cristina Maldonado-Araque, Albert Goday, E. Menéndez, Elena Bordiú, Eduard Montanya, Luis Castaño, Sara García-Serrano, Eva García-Escobar, Alfonso L. Calle-Pascual, Gemma Rojo-Martínez, Ana Lago-Sampedro, Sergio Valdés, Conxa Castell, José Luis Galán-García, Federico Soriguer, Elías Delgado, Roger R. Gomis, Sonia Gaztambide, Josep Franch-Nadal, Felipe J. Chaves, R. Badía

Publikováno v: Scientific Reports
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
RUO. Repositorio Institucional de la Universidad de Oviedo
SCIENTIFIC REPORTS
r-FISABIO. Repositorio Institucional de Producción Científica

This investigation has been supported by CIBERDEM (Ministerio de Economía, Industria y Competitividad-ISCIII), Ministerio de Sanidad, Servicios Sociales e Igualdad-ISCIII, Instituto de Salud Carlos III (research Grants PI18/01165, PI17/02136, PI14/0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e171d7d79cfd741f503339102429e0
https://doi.org/10.1038/s41598-021-95546-x