Výsledky vyhledávání - "Federico, Oldoni"

Akademický článek

Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets

Autor: Jingfei Chen, Zhenfei Fang, Qin Luo, Xiao Wang, Mohamad Warda, Avash Das, Federico Oldoni, Fei Luo

Publikováno v: Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-11 (2024)

Abstract Reducing circulating lipid levels is the centerpiece of strategies for preventing and treating atherosclerotic cardiovascular disease (ASCVD). Despite many available lipid-lowering medications, a substantial residual cardiovascular risk rema

Externí odkaz: https://doaj.org/article/2b9755b36d6c487a9cbfacba3ea05fc9

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Akademický článek

TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease

Autor: Fei Luo, Federico Oldoni, Avash Das

Publikováno v: Hepatology Communications, Vol 6, Iss 3, Pp 448-460 (2022)

Transmembrane 6 superfamily member 2 (TM6SF2) is located on chromosome 19 (19p12) and encodes for a protein of undetermined function. Genetic studies have reported the association between a nonsynonymous variant in TM6SF2 (E167K, rs58542926) with hep

Externí odkaz: https://doaj.org/article/5a16556afc7a4079b6ac05165d95c409

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Akademický článek

Role of ACSL5 in fatty acid metabolism

Autor: Qin Luo, Avash Das, Federico Oldoni, Panyun Wu, Jiangang Wang, Fei Luo, Zhenfei Fang

Publikováno v: Heliyon, Vol 9, Iss 2, Pp e13316- (2023)

Free fatty acids (FFAs) are essential energy sources for most body tissues. A fatty acid must be converted to fatty acyl-CoA to oxidize or be incorporated into new lipids. Acyl-CoA synthetase long-chain family member 5 (ACSL5) is localized in the end

Externí odkaz: https://doaj.org/article/5fa15fedf50e4495842ab601426b511e

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Akademický článek

A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis

Autor: Cristy R.C. Verzijl, Federico Oldoni, Natalia Loaiza, Justina C. Wolters, Antoine Rimbert, E. Tian, Weiming Yang, Dicky Struik, Marieke Smit, Niels J. Kloosterhuis, Amy J. Fernandez, Nadine L. Samara, Kelly G. Ten Hagen, Kruti Dalal, Aliona Chernish, Peggy McCluggage, Lawrence A. Tabak, Johan W. Jonker, Jan Albert Kuivenhoven

Publikováno v: Molecular Metabolism, Vol 60, Iss , Pp 101472- (2022)

Objective: GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification

Externí odkaz: https://doaj.org/article/ed1b5a2f73a641f4a58ccdb15e609510

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Akademický článek

ANGPTL8 has both endocrine and autocrine effects on substrate utilization

Autor: Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs

Publikováno v: JCI Insight, Vol 5, Iss 17 (2020)

The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is

Externí odkaz: https://doaj.org/article/1a1c3a9033be4a71b1a52e4fb1afa6f9

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Variants in the

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 42(10)

In mice, GPR146 (G-protein-coupled receptor 146) deficiency reduces plasma lipids and protects against atherosclerosis. Whether these findings translate to humans is unknown.Common and rare genetic variants in theIn the UK Biobank, carriers of the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87e391709d86a41f5fff02f40557b147
https://pubmed.ncbi.nlm.nih.gov/36047410

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Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8

Autor: Viktoria Gusarova, Lisa M. Shihanian, Julia Kozlitina, Federico Oldoni, Kevin Bass, Jonathan Cohen, Hannah Hudson, Helen H. Hobbs

Publikováno v: The Journal of Clinical Endocrinology and Metabolism

Context ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contributi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56431b4e31002897cad7400236140fb8
http://europepmc.org/articles/PMC8118582

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Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile

Publikováno v: Rimbert, A, Yeung, M W, Dalila, N, Thio, C H L, Yu, H, Loaiza, N, Oldoni, F, van der Graaf, A, Wang, S, Said, M A, Blauw, L L, Girardeau, A, Bray, L, Caillaud, A, Bloks, V W, Marrec, M, Mouli, P, Rensen, P C N, van de Sluis, B, Snieder, H, Di Filippo, M, van der Harst, P, Tybjaerg-Hansen, A, Zimmerman, P, Cariou, B & Kuivenhoven, J A 2022, ' Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 42, no. 10, pp. 1262-1271 . https://doi.org/10.1161/ATVBAHA.122.317514
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2022, 42 (10), pp.1262-1271. ⟨10.1161/atvbaha.122.317514⟩
Arteriosclerosis, thrombosis, and vascular biology, 42(10), 1262-1271. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, Thrombosis, and Vascular Biology, 42(10), 1262-1271. LIPPINCOTT WILLIAMS & WILKINS

Background:In mice, GPR146 (G-protein–coupled receptor 146) deficiency reduces plasma lipids and protects against atherosclerosis. Whether these findings translate to humans is unknown.Methods:Common and rare genetic variants in theGPR146gene locus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb70fea5501d89e9dcbe494d7a9b727
https://curis.ku.dk/ws/files/320753917/ATVBAHA.122.317514.pdf