Zobrazeno 1 - 10
of 375
pro vyhledávání: '"Federico, Innocenti"'
Autor:
Julia C.F. Quintanilha, Alexander B. Sibley, Yingmiao Liu, Donna Niedzwiecki, Susan Halabi, Layne Rogers, Bert O’Neil, Hedy Kindler, William Kelly, Alan Venook, Howard L. McLeod, Mark J. Ratain, Andrew B. Nixon, Federico Innocenti, Kouros Owzar
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Herein, we report results from a genome-wide study conducted to identify protein quantitative trait loci (pQTL) for circulating angiogenic and inflammatory protein markers in patients with metastatic colorectal cancer (mCRC). The
Externí odkaz:
https://doaj.org/article/363d6f8837684c528d797df314a685cf
Autor:
Elizabeth S. Nakasone, Tyler J. Zemla, Ming Yu, She Yu Lin, Fang-Shu Ou, Kelly Carter, Federico Innocenti, Leonard Saltz, William M. Grady, Stacey A. Cohen
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTWhile epigenomic alterations are common in colorectal cancers (CRC), few epigenomic biomarkers that risk-stratify patients have been identified. We thus sought to determine the potential of ZNF331 promoter hypermethylation (mZNF331) as a prog
Externí odkaz:
https://doaj.org/article/9934e8c678554cc0aff190ec4294bfc1
Autor:
Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer
Publikováno v:
eLife, Vol 13 (2024)
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanis
Externí odkaz:
https://doaj.org/article/f486b24826a64551bd611deb78f24793
Autor:
Fang-Shu Ou, Emil Lou, Joanne Xiu, Hiroyuki Arai, Francesca Battaglin, Heinz-Josef Lenz, Richard M Goldberg, Anthony F Shields, Yasmine Baca, Philip A Philip, John L Marshall, W Michael Korn, Andreas Seeber, Natsuko Kawanishi, Jingyuan Wang, Shivani Soni, Wu Zhang, Shannon M Mumenthaler, Joshua Millstein, Priya Jayachandran, Federico Innocenti, Annika Lenz, Sandra Algaze, Taline Khoukaz, Evanthia Roussos Torres, Jim P Abraham, Benjamin A Weinberg, Alan P Venook
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background The C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated with CCR5/CCL5 expression in CRC and to determine
Externí odkaz:
https://doaj.org/article/0070d43d733f41d1a13e1ef74847bb8d
Autor:
John Mascarenhas, Lei He, Rabih Saab, Nashat Gabrail, Keita Kirito, Deanna Brackman, Federico Innocenti
Publikováno v:
HemaSphere, Vol 7, p e8258903 (2023)
Externí odkaz:
https://doaj.org/article/5bb743f1e2b441bdbb220cb3d815f662
Autor:
Lynn Symonds, Ming Yu, YuHong Zhang, Fang-Shu Ou, Tyler J. Zemla, Kelly Carter, Monica Bertagnolli, Federico Innocenti, Linda JW Bosch, Gerrit A Meijer, Beatriz Carvalho, William M. Grady, Stacey A. Cohen
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1715-1725 (2022)
Aberrantly methylated genes contribute to the landscape of epigenetic alterations in colorectal adenocarcinoma. The global CpG Island methylator phenotype (CIMP) and individually methylated genes are potential prognostic/predictive biomarkers. Resear
Externí odkaz:
https://doaj.org/article/fedc615c145b49aa9716d591e2847ecb
Autor:
Radia M. Johnson, Xueping Qu, Chu-Fang Lin, Ling-Yuh Huw, Avinashnarayan Venkatanarayan, Ethan Sokol, Fang-Shu Ou, Nnamdi Ihuegbu, Oliver A. Zill, Omar Kabbarah, Lisa Wang, Richard Bourgon, Felipe de Sousa e Melo, Chris Bolen, Anneleen Daemen, Alan P. Venook, Federico Innocenti, Heinz-Josef Lenz, Carlos Bais
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
ARID1A is an epigenetic regulator mutated in approximately 5% of non-hypermutated colorectal cancer tumors, however, its relationship with treatment response remains to be explored. Here, the authors suggest that ARID1A mutations may confer intrinsic
Externí odkaz:
https://doaj.org/article/4488b89ca7bf43bdb1d09041a86d2a0c
Autor:
Yi-Hui Zhou, Paul J. Gallins, Amy S. Etheridge, Dereje Jima, Elizabeth Scholl, Fred A. Wright, Federico Innocenti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In this study, we generated whole-transcriptome RNA-Seq from n = 192 genotyped liver samples and used these data with existing data from the GTEx Project (RNA-Seq) and previous liver eQTL (microarray) studies to create an enhanced transcript
Externí odkaz:
https://doaj.org/article/dfbeb7486ce4448bb00b807a6007bd53
Publikováno v:
Human Behavior and Emerging Technologies, Vol 2023 (2023)
The use of social media has frequently been misunderstood. Scholars worldwide have attempted to investigate patterns in social media use, with several attempts to frame it as a problematic behavior linked to negative consequences. However, among the
Externí odkaz:
https://doaj.org/article/3b403c9fdc054b66989a2ff8fabcfa17
Autor:
Jiaxing Lin, Alexander Sibley, Ivo Shterev, Andrew Nixon, Federico Innocenti, Cliburn Chan, Kouros Owzar
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Parametric feature selection methods for machine learning and association studies based on genetic data are not robust with respect to outliers or influential observations. While rank-based, distribution-free statistics offer a ro
Externí odkaz:
https://doaj.org/article/c266a7f152e64839a4b9bb84c023017d