Zobrazeno 1 - 10
of 456
pro vyhledávání: '"Federico, Gago"'
Autor:
Akbar Espaillat, Laura Alvarez, Gabriel Torrens, Josy ter Beek, Vega Miguel-Ruano, Oihane Irazoki, Federico Gago, Juan A. Hermoso, Ronnie P-A. Berntsson, Felipe Cava
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The bacterial cell-wall peptidoglycan is made of glycan strands crosslinked by short peptide stems. Crosslinks are catalyzed by DD-transpeptidases (4,3-crosslinks) and LD-transpeptidases (3,3-crosslinks). However, recent research on non-mode
Externí odkaz:
https://doaj.org/article/f373c1092527467592fe75b975bb0cf4
Autor:
Siseth Martínez-Caballero, Céline Freton, Rafael Molina, Sergio G. Bartual, Virginie Gueguen-Chaignon, Chryslène Mercy, Federico Gago, Kiran V. Mahasenan, Inés G. Muñoz, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, Juan A. Hermoso, Christophe Grangeasse
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112756- (2023)
Summary: Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a multidisciplinary work, we disclose the molecular dialogue be
Externí odkaz:
https://doaj.org/article/d81c8fc5e2aa4f5d9ff7f86ec5f0dc25
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Olaia Martí-Marí, Rana Abdelnabi, Dominique Schols, Johan Neyts, María-José Camarasa, Federico Gago, Ana San-Félix
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3539 (2023)
AL-471, the leading exponent of a class of potent HIV and enterovirus A71 (EV-A71) entry inhibitors discovered in our research group, contains four l-tryptophan (Trp) units bearing an aromatic isophthalic acid directly attached to the C2 position of
Externí odkaz:
https://doaj.org/article/082313cde67a407c966bf63dc027464d
Computational Approaches to Enzyme Inhibition by Marine Natural Products in the Search for New Drugs
Autor:
Federico Gago
Publikováno v:
Marine Drugs, Vol 21, Iss 2, p 100 (2023)
The exploration of biologically relevant chemical space for the discovery of small bioactive molecules present in marine organisms has led not only to important advances in certain therapeutic areas, but also to a better understanding of many life pr
Externí odkaz:
https://doaj.org/article/145916ed9f814c63a14d081aa2b18919
Autor:
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1021 (2022)
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–ac
Externí odkaz:
https://doaj.org/article/d301b0071e384bba936c2d8ac80db4e5
Publikováno v:
ACS Omega. 8:3540-3550
11 p.-3 fig.
Microtubules (MTs) are essential cellular machines built from concatenated αβ-tubulin heterodimers. They are responsible for two central and opposite functions from the dynamic point of view: scaffolding (static filaments) and for
Microtubules (MTs) are essential cellular machines built from concatenated αβ-tubulin heterodimers. They are responsible for two central and opposite functions from the dynamic point of view: scaffolding (static filaments) and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba1f4d0949e4943d2b2c28dae876d85
https://doi.org/10.1021/acsomega.2c06926
https://doi.org/10.1021/acsomega.2c06926
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Nucleoside-2′-deoxyribosyl-transferases (NDTs) catalyze a transglycosylation reaction consisting of the exchange of the 2′-deoxyribose moiety between a purine and/or pyrimidine nucleoside and a purine and/or pyrimidine base. Because NDTs are high
Externí odkaz:
https://doaj.org/article/831f28eaf51b49e7a14408b9fcfdd9db
Autor:
Alejandro Revuelto, Isabel López-Martín, Héctor de Lucio, Juan Carlos García-Soriano, Nicola Zanda, Sonia de Castro, Federico Gago, Antonio Jiménez-Ruiz, Sonsoles Velázquez, María-José Camarasa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 689 (2021)
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Externí odkaz:
https://doaj.org/article/ae16e1932b9142b884536d0bb5ad011f
Autor:
Alberto Mills, Federico Gago
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6973 (2021)
eEF1A1 and eEF1A2 are paralogous proteins whose presence in most normal eukaryotic cells is mutually exclusive and developmentally regulated. Often described in the scientific literature under the collective name eEF1A, which stands for eukaryotic el
Externí odkaz:
https://doaj.org/article/ffbe69ee812341f0b4bb913c06ed5ec1