Výsledky vyhledávání - "Federica Tomassoni"

Tissue-specific dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls

Autor: Uberto Pagotto, Federica Tomassoni, Ruth Andrew, Renato Pasquali, Alessandra Gambineri, Flaminia Fanelli, Brian R. Walker, Alessandra Munarini

Publikováno v: European Journal of Endocrinology. 171:47-57

ContextAbnormal cortisol metabolism in polycystic ovary syndrome (PCOS) has been invoked as a cause of secondary activation of the hypothalamic–pituitary–adrenal axis and hence androgen excess. However, this is based on urinary excretion of corti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b6ea6c70fcca4b3a7b788f8129f7b9
https://doi.org/10.1530/eje-13-1030

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Is there a dose-response relationship of metformin treatment in patients with polycystic ovary syndrome? Results from a multicentric study

Autor: C. Di Florio, Alessandra Gambineri, A. M. Fulghesu, Luigi Minerba, Renato Pasquali, Valeria Tagliaferri, S Sanna, Daniela Romualdi, Federica Tomassoni, Antonio Lanzone

Study question Do different dosages of metformin account for different clinical and biochemical outcomes in women with polycystic ovary syndrome (PCOS) and do basal anthropometric and metabolic characteristics of the patients provide any indications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc9bb678765ce214fb2200ec6c4b650
http://hdl.handle.net/10807/63296

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A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

Autor: Alessandra Munarini, Vilma Mantovani, Renato Pasquali, Alessandra Gambineri, Ruth Andrew, Uberto Pagotto, Karen E. Chapman, Federica Tomassoni, Brian R. Walker, Roberto Mioni, Roland H Stimson

ObjectiveRegeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e5eb50b0c0722c1c65cac554201d10
http://hdl.handle.net/11585/107266

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Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome

Autor: Uberto Pagotto, Paola Altieri, Alessandra Gambineri, Vilma Mantovani, Anna Maria Fulghesu, Antonio Di Rocco, S Sanna, Daniela Ibarra Gasparini, Federica Tomassoni, Renato Pasquali

Publikováno v: The Journal of clinical endocrinology and metabolism. 95(10)

The determinants of the variability in the clinical response to metformin in women with the polycystic ovary syndrome (PCOS) are enigmatic. Organic cation transporter 1 (OCT1) plays a trigger role in the hepatic uptake of metformin. In cellular studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f9bca3bdbe5525b92e4be356303575
https://pubmed.ncbi.nlm.nih.gov/20660041

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Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome

Autor: Brian R. Walker, Uberto Pagotto, Federica Tomassoni, Giulia Forlani, Graciela Estela Cognigni, Alessandra Gambineri, Alessandra Munarini, Renato Pasquali, W. Ciampaglia

Increased peripheral metabolism of cortisol may explain compensatory ACTH-dependent adrenal steroidogenesis and hence hyperandrogenism in polycystic ovary syndrome (PCOS). Previous studies have described an increased 5alpha-reduction of cortisol or i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b7fe052f57ef9f7dd997659c33549d
http://hdl.handle.net/11585/78964

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Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome

Autor: Silvia Genghini, Alessandra Gambineri, Brian R. Walker, Federica Tomassoni, Renato Pasquali, Valentina Vicennati, Uberto Pagotto

Elevated adrenal androgen levels are common in polycystic ovary syndrome (PCOS), but the underlying pathogenetic mechanism is poorly understood. In the rare cortisone reductase deficiency, impaired regeneration of active cortisol from inert cortisone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4551fd81bff44e9784cb4a551593ee1e
http://hdl.handle.net/11585/32529

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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Autor: Enzo Nisoli, Alexander Yassouridis, Dorothee P. Auer, Sylvia Ortmann, Uberto Pagotto, M. I. Schubert, Daniela Cota, Günter K. Stalla, Federica Tomassoni, Matthias H. Tschöp, Beat Lutz, Cristina Cervino, Yvonne Grübler, Astrid C E Linthorst, Giovanni Marsicano, Christa Thöne-Reineke, Cornelia Flachskamm, Renato Pasquali

The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43316036e0ed64d1b19f94a122a9ad9
https://europepmc.org/articles/PMC166293/

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Serum xanthine oxidase in human liver disease

Autor: Marco Valgimigli, Laura Gramantieri, Fiorenzo Stirpe, Luigi Bolondi, Maria Giulia Battelli, Federica Tomassoni, Silvia Musiani

Publikováno v: The American journal of gastroenterology. 96(4)

OBJECTIVES: High concentrations of serum xanthine oxidase (XO) have been reported during human liver disease and hepatocyte injury in experimental settings. However, it is unclear whether this elevation reflects hepatocyte necrosis or has a different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e541636198a2d590c0fd9dc52b87311
https://pubmed.ncbi.nlm.nih.gov/11316169

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