Výsledky vyhledávání - "Federica Stazi"

A Mechanistic Insight into a Simple C−N Bond Formation via SN2 Displacement: A Synergistic Kinetics and Design of Experiment Approach

Autor: Federico Scaravelli, Laura Panelli, Federica Stazi, Pieter Westerduin, Luca Massari, Sergio Bacchi, William Maton, Mark J. Hughes

Publikováno v: Organic Process Research & Development. 14:1364-1372

A novel series of 1,2,4-triazol-3-yl-azabicyclo[3.1.0]hexanes was recently identified as new highly potent and selective dopamine (DA) D3 receptor antagonists. This class of molecules deserved the Chemical Development special attention to quantify th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef78ccbdc54567c6f4cb5580990fb21b
https://doi.org/10.1021/op100176u

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An Efficient Scalable Route for the Synthesis of Enantiomerically Pure tert-Butyl-(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

Publikováno v: Organic Process Research & Development. 14:1239-1247

An efficient scalable route to synthesize the enantiomerically pure tert-butyl-(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate is described. Compared to the original routes, significant improvements were made by using an innovat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb19119ea9299a9302fec3bb306f634d
https://doi.org/10.1021/op100164v

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Efficient Methods for the Synthesis of Arylacetonitriles

Autor: Federica Stazi, Pieter Westerduin, Damiano Castoldi, Sergio Bacchi, Ornella Curcuruto, William Maton

Publikováno v: Synthesis. 2010:3332-3338

Various approaches to [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile were investigated. Two of these methods were selected and applied to a variety of electron-deficient substrates, thereby expanding the scopes of the procedures.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94c34a52cea5252b20592c9145edc522
https://doi.org/10.1055/s-0030-1257871

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Accelerated Koenigs−Knorr Glucuronidation of a Deactivated Nitrophenol: Unveiling the Role of Polyamine Additive 1,1,4,7,10,10-Hexamethyltriethylenetetramine1 through Design of Experiments

Autor: Simona Clini, Marco Santagostino, Giovanni Palmisano, Marco Turconi, Federica Stazi

Publikováno v: The Journal of Organic Chemistry. 69:1097-1103

1,1,4,7,10,10-Hexamethyltriethylenetetramine (HMTTA) emerged from a limited parallel screening of selected polyamines as the most appropriate additive for an especially problematic Koenigs-Knorr glucuronidation. This initial finding rapidly evolved i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59d688a661a022c172edf0b28359462d
https://doi.org/10.1021/jo035285n

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Unexpected reactivity of 2-fluoro-4-(trifluoromethyl)-phenylacetonitrile: isolation and characterization of a trimeric impurity

Autor: Stefano Provera, Federica Stazi, Ornella Curcuruto, Sergio Bacchi, Pieter Westerduin

Publikováno v: Tetrahedron Letters. 51:5434-5436

An uncommon reactivity of 2-fluoro-4-(trifluoromethyl)-phenylacetonitrile, with the loss of three fluorine atoms, is herein reported, the resulting trimeric compound was isolated and characterized by NMR and MS/MS studies. An unprecedented mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cd28f14043b234a01b8f9233b58dbec
https://doi.org/10.1016/j.tetlet.2010.08.007

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Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

Autor: Damiano Cancogni, Pieter Westerduin, Lucilla Turco, Federica Stazi, Sergio Bacchi

Publikováno v: Tetrahedron Letters. 51:5385-5387

The Letter reports a safe and reliable synthesis of aryl 1,2,3-triazoles from the corresponding anilines via intermediate aryl azides, using a continuous process. The method was applied to a variety of substrates with good to excellent yields, withou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c8337110d990b428cdaa888fadb461
https://doi.org/10.1016/j.tetlet.2010.07.149

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