Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.

Autor: Erin Garrigan, Nicole S Belkin, John J Alexander, Zhao Han, Federica Seydel, Jamal Carter, Mark Atkinson, Clive Wasserfall, Michael J Clare-Salzler, Matthew A Amick, Sally A Litherland

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76919 (2013)

STAT5 proteins are adaptor proteins for histone acetylation enzymes. Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, suc

Externí odkaz: https://doaj.org/article/4b18d309b15a4f27bef17360300969f3

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

Autor: Maxence V. Nachury, David K. Breslow, Andrew J. Spakowitz, Elena F. Koslover, Federica Seydel

Publikováno v: Breslow, DK; Koslover, EF; Seydel, F; Spakowitz, AJ; & Nachury, MV. (2013). An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. JOURNAL OF CELL BIOLOGY, 203(1), 129-147. doi: 10.1083/jcb.201212024. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2nz052f1
The Journal of Cell Biology

The ciliary permeability barrier is mechanistically distinct from other cellular diffusion barriers and allows soluble proteins under ∼100 kD in size to enter cilia in the absence of active transport.
Specific proteins are concentrated within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3505ed17826938be44293ac81e8586f6
https://doi.org/10.1083/jcb.201212024

M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice

Autor: Nicole S. Belkin, Erin Garrigan, B. Stutevoss, Federica Seydel, Jessica L. Elf, Sally A. Litherland, B. Rumore-Maton

Publikováno v: Clinical and Developmental Immunology, Vol 2008 (2008)
Clinical and Developmental Immunology

Defects in macrophage colony-stimulating factor (M-CSF) signaling disrupt myeloid cell differentiation in nonobese diabetic (NOD) mice, blocking myeloid maturation into tolerogenic antigen-presenting cells (APCs). In the absence of M-CSF signaling, N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af29214c945b1c7c037754fc865a1e57