Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Federica Prosperi"'
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Akademický článek
Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice
Autor: Anna Iervolino, Luigi R. De La Motte, Federica Petrillo, Federica Prosperi, Francesca Maria Alvino, Guglielmo Schiano, Alessandra F. Perna, Danilo Di Matteo, Mario De Felice, Giovambattista Capasso, Francesco Trepiccione
Publikováno v: Frontiers in Physiology, Vol 9 (2018)
Integrins are heterodimers anchoring cells to the surrounding extracellular matrix (ECM), an active and complex process mediating a series of inside-out and outside-in stimuli regulating cellular turn-over, tissue growth and architecture. Itgb1 is th
Externí odkaz: https://doaj.org/article/0bac6e2a816d4e3aa6b597d3e58a8c83
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3
Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation
Autor: Emanuele Miraglia del Giudice, Pierluigi Marzuillo, Stefano Guarino, Vincenzo Costanzo, Anna Iervolino, Emmanuelle Cordat, Giovambattista Capasso, Miriam Zacchia, Yoko Suzumoto, Francesco Trepiccione, Federica Prosperi, Alessandra F. Perna, Angela La Manna, Sabina Jelen
Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Nephrogenic diabetes insipidus (NDI) is a rare tubulopathy characterized by urinary concentration defect due to renal resistance to vasopressin. Loss-of-function mutations of vasopressin V2 receptor (V2R) gene (AVPR2) is the most common cause of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c24aa8cd14a99cdceb66358724ed2a8
https://pubmed.ncbi.nlm.nih.gov/33009446
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4
Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway
Autor: Mariavittoria D'Acierno, Alessandra F. Perna, Giovambattista Capasso, Birgitte Mønster Christensen, Luigi R De La Motte, Federica Prosperi, Manuela Spagnuolo, Anna Iervolino, Sebastian Frische, Federica Petrillo, Sabrina Siccardi, Francesco Trepiccione
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Iervolino, A, Prosperi, F, De La Motte, L R, Petrillo, F, Spagnuolo, M, D’Acierno, M, Siccardi, S, Perna, A F, Christensen, B M, Frische, S, Capasso, G & Trepiccione, F 2020, ' Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway ', Scientific Reports, vol. 10, no. 1, 5708 . https://doi.org/10.1038/s41598-020-61882-7
Scientific Reports
Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2d5fa3be7f44a1ff84c76b0ef14e68
https://doi.org/10.1038/s41598-020-61882-7
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5
Antitumor activity of novel POLA1-HDAC11 dual inhibitors
Autor: Loana Musso, Claudio Pisano, Federica Prosperi, Fabiana Colelli, Maddalena Pizzulo, Sabrina Dallavalle, Giacomo Signorino, Elisa Modica, Nadine Darwiche, Egildo Luca D'Andrea, Ilaria La Porta, Raffaella Cincinelli, Silvia Gervasoni, Giulio Vistoli, Francesco Cardile, Alessandra Fucci, Assunta Riccio, Mario B. Guglielmi
Publikováno v: European Journal of Medicinal Chemistry. 228:113971
Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action. Among a library of screened molecules, MIR002 and GEM144 showed antiprolifera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22e09537d903caaba420079a4d3bf57
https://doi.org/10.1016/j.ejmech.2021.113971
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6
New Findings on the Pathogenesis of Distal Renal Tubular Acidosis
Autor: Luigi R De La Motte, Régine Chambrey, Francesco Trepiccione, Dominique Eladari, Christian A. Hübner, Federica Prosperi, Giovambattista Capasso
Publikováno v: American Journal of Kidney Diseases
American Journal of Kidney Diseases, Elsevier, 2017, 3 (3), pp.98-105. ⟨10.1159/000478781⟩
Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of the urinary acidification process in the distal nephron. Complete or incomplete metabolic acidosis coupled with inappropriately alkaline urine are the hallmarks of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb9394ca35cba851541ea90ff1a292a
https://doi.org/10.1159/000478781
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