Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Federica Polato"'
Autor:
Jianqi Yang, Alison N DeVore, Daniel A Fu, Mackenzie M Spicer, Mengcheng Guo, Samantha G Thompson, Katelin E Ahlers-Dannen, Federica Polato, Andre Nussenzweig, Rory A Fisher
Publikováno v:
Life Science Alliance. 6:e202201729
Precise determination of transgene zygosity is essential for use of transgenic mice in research. Because integration loci of transgenes are usually unknown due to their random insertion, assessment of transgene zygosity remains a challenge. Current z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afdc4e1cf8310019585d9b5993ead905
https://doi.org/10.26508/lsa.202201729
https://doi.org/10.26508/lsa.202201729
Autor:
Jeanee Bullock, Federica Polato, Daniel C. Lulli, Vatsala Sagar, Laura Abaandou, Joseph Shiloach, S. Patricia Becerra
Publikováno v:
Protein Expr Purif
Human SERPINF1 gene codes for pigment epithelium-derived factor (PEDF), a secreted glycoprotein and member of the SERPIN superfamily. To obtain large amounts of recombinant PEDF proteins, we subcloned the coding sequence of human SERPINF1 mutated ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7315d034de8d58e9e9cef6db6af04d21
https://doi.org/10.1016/j.pep.2022.106072
https://doi.org/10.1016/j.pep.2022.106072
Autor:
Elma Aflaki, Jeanee Bullock, S. Patricia Becerra, Martin-Paul Agbaga, Alexandra Bernardo-Colón, Federica Polato, Mones Abu-Asab
Publikováno v:
Investigative Ophthalmology & Visual Science
PurposeTo examine the contribution of PEDF-R to the phagocytosis process. Previously, we identified PEDF-R, the protein encoded by thePNPLA2gene, as a phospholipase A2 in the retinal pigment epithelium (RPE). During phagocytosis, RPE cells ingest abu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91431ab987d41003fecde6e91e91bfa6
http://europepmc.org/articles/PMC7900850
http://europepmc.org/articles/PMC7900850
Autor:
Mones Abu-Asab, Shivani Dixit, Federica Polato, S. Patricia Becerra, Marijana Samardzija, Susan E. Crawford, Christian Grimm
Publikováno v:
Exp Eye Res
The SERPINF1 gene encodes pigment epithelium-derived factor (PEDF), a member of the serpin superfamily with neurotrophic and antiangiogenic properties in the retina. We hypothesized that absence of PEDF would lead to increased stress-associated retin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a3423ff81ec3f3719c58f81d5f689a
https://www.zora.uzh.ch/id/eprint/192457/
https://www.zora.uzh.ch/id/eprint/192457/
Autor:
Enrique J. de la Rosa, Susan Vitale, Andrés de la Rocha-Muñoz, Alberto M. Hernández-Pinto, Federica Polato, Preeti Subramanian, S. Patricia Becerra
Publikováno v:
Exp Eye Res
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
24 p. 2 fig.
The purpose of the study is to evaluate the protective properties of PEDF peptide fragments on rd10 mouse models of retinal degeneration ex vivo. Human recombinant PEDF and synthetic peptides were used. Rd10 retinal explants as well
The purpose of the study is to evaluate the protective properties of PEDF peptide fragments on rd10 mouse models of retinal degeneration ex vivo. Human recombinant PEDF and synthetic peptides were used. Rd10 retinal explants as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9e3e09d854c3bc984fd6bea88eda2f
http://hdl.handle.net/10261/180216
http://hdl.handle.net/10261/180216
Autor:
Jason Kenealey, Valeria Marigo, Antonella Comitato, Federica Polato, David Hoover, Jeanee Bullock, Preeti Subramanian, Laura Keehan, S. Patricia Becerra
Publikováno v:
Journal of Biological Chemistry. 290:25241-25253
The cytoprotective effects of pigment epithelium-derived factor (PEDF) require interactions between an as of a yet undefined region with a distinct ectodomain on the PEDF receptor (PEDF-R). Here we characterized the area in PEDF that interacts with P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea2e387ee4fbb2e50667244df20b0dd
https://doi.org/10.1074/jbc.m115.645846
https://doi.org/10.1074/jbc.m115.645846
Autor:
Jeremy A. Daniel, Oscar Fernandez-Capetillo, Anthony T. Tubbs, Ji-Eun Lee, Linda M. Starnes, Michael J. Kruhlak, Federica Polato, Frederick W. Alt, Hua Tang Chen, Kai Ge, Elsa Callen, Barry P. Sleckman, Michel C. Nussenzweig, Robert B. Faryabi, Margarida A. Santos, Maria Nieto-Soler, Duane R. Wesemann, André Nussenzweig, Michela Di Virgilio, Nancy Wong
Publikováno v:
Cell. 153:1266-1280
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae56704bb9696e10e6ab600e5947e0e
https://doi.org/10.1016/j.cell.2013.05.023
https://doi.org/10.1016/j.cell.2013.05.023
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Autor:
Samuel F. Bunting, Xiaoling Xu, Federica Polato, Niklas Feldhahn, Nancy Wong, Oscar Fernandez-Capetillo, André Nussenzweig, Anne Bothmer, Liu Cao, Chu-Xia Deng, Amanda Gunn, Hua Tang Chen, Michel C. Nussenzweig, Jeremy M. Stark, Elsa Callen, Toren Finkel
Publikováno v:
Cell
SummaryDefective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284dd9922e4c4eb98d6ca01019f3289d
https://doi.org/10.1016/j.cell.2010.03.012
https://doi.org/10.1016/j.cell.2010.03.012
Autor:
S. Patricia Becerra, Federica Polato
Publikováno v:
Adv Exp Med Biol
Retinal Degenerative Diseases ISBN: 9783319171203
Retinal Degenerative Diseases ISBN: 9783319171203
Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on photo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb5c6c2c674afaf40129fdbabd53da7
https://pubmed.ncbi.nlm.nih.gov/26427478
https://pubmed.ncbi.nlm.nih.gov/26427478
Autor:
Eugenio Scanziani, Sergio Marchini, Massimo Broggini, E. Riccardi, Mirko Marabese, Federica Polato, Faina Vikhanskaya, Maria Antonietta Sabatino, Eleonora Marrazzo
Publikováno v:
Cell Death & Differentiation. 12:805-814
The p73 gene has a complex regulation, which leads to the expression of different isoforms, often with opposite biological effects. We have generated in the human colocarcinoma cell line HCT116, expressing a wild-type p53, an inducible DNp73alpha exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393a906d341414bada457a784d0890ef
https://doi.org/10.1038/sj.cdd.4401622
https://doi.org/10.1038/sj.cdd.4401622