Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Federica Gabriele"'
Autor:
Valentina Z. Petukhova, Sammy Y. Aboagye, Matteo Ardini, Rachel P. Lullo, Francesca Fata, Margaret E. Byrne, Federica Gabriele, Lucy M. Martin, Luke N. M. Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D. Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Grégory Effantin, Wai Li Ling, Jeremy J. Johnson, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams, Pavel A. Petukhov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass drug administration programs suggest t
Externí odkaz:
https://doaj.org/article/be068dfc60f64b079ddfa79996f6b0e8
Autor:
Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S.J. Arnér, Francesco Angelucci
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102278- (2022)
Enzymes in the thiol redox systems of microbial pathogens are promising targets for drug development. In this study we characterized the thioredoxin reductase (TrxR) selenoproteins from Brugia malayi and Onchocerca volvulus, filarial nematode parasit
Externí odkaz:
https://doaj.org/article/3ad78271ac504fecbdcd50d7a6474ac7
Autor:
Francesca Fata, Federica Gabriele, Francesco Angelucci, Rodolfo Ippoliti, Luana Di Leandro, Francesco Giansanti, Matteo Ardini
Publikováno v:
Sensors, Vol 23, Iss 2, p 949 (2023)
The demonstration of the first enzyme-based electrode to detect glucose, published in 1967 by S. J. Updike and G. P. Hicks, kicked off huge efforts in building sensors where biomolecules are exploited as native or modified to achieve new or improved
Externí odkaz:
https://doaj.org/article/f79fcdbcd5e743d5a5d51366bb42e6f0
Autor:
Federica Gabriele, Marta Palerma, Rodolfo Ippoliti, Francesco Angelucci, Giuseppina Pitari, Matteo Ardini
Affibodies and designed ankyrin repeat proteins (DARPins) are synthetic proteins originally derived from the Staphylococcus aureus virulence factor protein A and the human ankyrin repeat proteins, respectively. The use of these molecules in healthcar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d15a5e590eb46eae5d7176cbbe05230
https://hdl.handle.net/11697/205219
https://hdl.handle.net/11697/205219
Autor:
Valentina Petukhova, Samuel Aboagye, Matteo Ardini, Rachel Lullo, Margaret Byrne, Lucy Martin, Francesca Fata, Federica Gabriele, Rodolfo Ippoliti, Wai Li Ling, Grégory Effantin, Luke Harding, Dejan Nikolic, Daniel Lantvit, Bikash Dangi, Vamshikrishna Gone, Jeremy Johnson, Gregory Thatcher, Francesco Angelucci, David Williams, Pavel Petukhov
Only one drug, praziquantel, is available for treating schistosomiasis, a disease affecting more than 200 million people. Laboratory studies have shown that schistosome worms can develop resistance to praziquantel and low cure rates from mass drug ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d86a36268bc208b4a3a9fdecfc0b73
https://hdl.handle.net/11697/194259
https://hdl.handle.net/11697/194259
Autor:
Emil Märcher-Rørsted, Henrik Pedersen, Thor C. Møller, Federica Gabriele, Dariusz Matosiuk, Hans Bräuner-Osborne, Tomasz M. Wróbel, Daniel Sejer Pedersen, Simon R. Foster, Michel Bouvier, Mie Fabricius Pedersen
Publikováno v:
Neuropharmacology
Pedersen, M F, Wrobel, T M, Märcher-Rørsted, E, Pedersen, D S, Møller, T C, Gabriele, F, Pedersen, H, Matosiuk, D, Foster, S R, Bouvier, M & Bräuner-Osborne, H 2020, ' Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics ', Neuropharmacology, vol. 166, 107718 . https://doi.org/10.1016/j.neuropharm.2019.107718
Pedersen, M F, Wrobel, T M, Märcher-Rørsted, E, Pedersen, D S, Møller, T C, Gabriele, F, Pedersen, H, Matosiuk, D, Foster, S R, Bouvier, M & Bräuner-Osborne, H 2020, ' Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics ', Neuropharmacology, vol. 166, 107718 . https://doi.org/10.1016/j.neuropharm.2019.107718
Binding and signaling kinetics have previously proven important in validation of biased agonism at GPCRs. Here we provide a comprehensive kinetic pharmacological comparison of clinically relevant μ-opioid receptor agonists, including the novel biase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295028ff384107141cadb2a6d6fbd5ed