Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Federica Farinelli"'
Autor:
Sumita Mishra, Junfeng Ma, Desirae McKoy, Masayuki Sasaki, Federica Farinelli, Richard C. Page, Mark J. Ranek, Natasha Zachara, David A. Kass
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106294- (2023)
Summary: Transient receptor potential canonical type 6 (TRPC6) is a non-voltage-gated channel that principally conducts calcium. Elevated channel activation contributes to fibrosis, hypertrophy, and proteinuria, often coupled to stimulation of nuclea
Externí odkaz:
https://doaj.org/article/384a06f3f1a64bf0a65db1f0836c7956
Autor:
Jesse B. Yoder, Manu Ben-Johny, Federica Farinelli, Lakshmi Srinivasan, Sophie R. Shoemaker, Gordon F. Tomaselli, Sandra B. Gabelli, L. Mario Amzel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2 +-dependent inactivation while cardiac NaV1.5 is not. Here authors use structural biology, binding and electrophysiology to parse the Ca2 +-depend
Externí odkaz:
https://doaj.org/article/dfd0a8426542457a852ee9eb17bcb1d2
Autor:
Brittany A. Davis, Huei-Ying Chen, Zengyou Ye, Isaac Ostlund, Madhavi Tippani, Debamitra Das, Srinidhi Rao Sripathy, Yanhong Wang, Jacqueline M. Martin, Gina Shim, Neel M. Panchwagh, Rebecca L. Moses, Federica Farinelli, Joseph F. Bohlen, Meijie Li, Bryan W. Luikart, Andrew E. Jaffe, Brady J. Maher
Genetic variation in the transcription factor 4 (TCF4)gene is associated with risk for a variety of developmental and psychiatric conditions, which includes a syndromic form of ASD called Pitt Hopkins Syndrome (PTHS).TCF4encodes an activity-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed46456bf887b9b844993a055651780
https://doi.org/10.1101/2023.01.19.524788
https://doi.org/10.1101/2023.01.19.524788
Autor:
Srinidhi Rao Sripathy, Stephanie Cerceo Page, Federica Farinelli, Zengyou Ye, Yanhong Wang, Debamitra Das, Gina Shim, Daniel J. Hiler, Elizabeth A. Pattie, Claudia V. Nguyen, Madhavi Tippani, Huei-Ying Chen, Matthew N. Tran, Nicholas J. Eagles, Joshua M. Stolz, Joseph L. Catallini, Olivia R. Soudry, Dwight Dickinson, Daniel R. Weinberger, Keri Martinowich, Matthew L. MacDonald, Joo Heon Shin, Andrew E. Jaffe, Richard E. Straub, Brady J. Maher
Publikováno v:
Biological Psychiatry. 93:S216
Autor:
Sumita Mishra, Junfeng Ma, Masayuki Sasaki, Federica Farinelli, Richard C. Page, Mark J. Ranek, Natasha Zachara, David A Kass
Transient receptor potential canonical type 6 (TRPC6) is a non-voltage gated cation channel that principally conducts calcium to regulate signaling in cardiac, vascular, neuronal and other cells. Abnormally increased TRPC6 expression/conductance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06be538ac71eb3b6bb3c6300e7234885
https://doi.org/10.1101/2022.06.15.496344
https://doi.org/10.1101/2022.06.15.496344
Autor:
Lakshmi Srinivasan, Sandra B. Gabelli, Jesse B. Yoder, Gordon F. Tomaselli, Sophie R. Shoemaker, L. Mario Amzel, Manu Ben-Johny, Federica Farinelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2+-dependent inactivation; no such inactivation is observed in the cardiac Na+ channel (NaV1.5). Taken together, the crystal structures of the NaV1.
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1722
Integral to the cell surface is channels, pumps, and exchanger proteins that facilitate the movement of ions across the membrane. Ion channels facilitate the passive movement of ions down an electrochemical gradient. Ion pumps actively use energy to
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975518
Integral to the cell surface is channels, pumps, and exchanger proteins that facilitate the movement of ions across the membrane. Ion channels facilitate the passive movement of ions down an electrochemical gradient. Ion pumps actively use energy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744f413ea0213fcdc41f6fcdffaed090
https://doi.org/10.1007/978-1-4939-7553-2_11
https://doi.org/10.1007/978-1-4939-7553-2_11
Autor:
Gordon F. Tomaselli, Ruiji Jiang, Andrew F. Malone, Alison Homstad, Rasheed Gbadegesin, Robert F. Spurney, Janelle Rowell, Guanghong Wu, Federica Farinelli, Michelle P. Winn, Gentzon Hall, Peter Lavin, David A. Kass, Thomas Lindsey
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F1442-F1450
The emerging role of the transient receptor potential cation channel isotype 6 (TRPC6) as a central contributor to various pathological processes affecting podocytes has generated interest in the development of therapeutics to modulate its function.
Autor:
Takeshi Aiba, Geran Kostecki, Federica Farinelli, Leslie Tung, David Edwards, Geoffrey G. Hesketh, Subrata Biswas, Gordon F. Tomaselli
Publikováno v:
Circulation: Cardiovascular Genetics. 7:249-256
Background— The mechanisms of the electrocardiographic changes and arrhythmias in Brugada syndrome (BrS) remain controversial. Mutations in the sodium channel gene, SCN5A , and regulatory proteins that reduce or eliminate sodium current ( I Na ) ha