Autoimmunity in thymic epithelial tumors: a not yet clarified pathologic paradigm associated with several unmet clinical needs

Autor: Matteo Perrino, Emanuele Voulaz, Simone Balin, Gerardo Cazzato, Elena Fontana, Sara Franzese, Martina Defendi, Fabio De Vincenzo, Nadia Cordua, Roberto Tamma, Federica Borea, Marta Aliprandi, Marco Airoldi, Luigi Giovanni Cecchi, Roberta Fazio, Marco Alloisio, Giuseppe Marulli, Armando Santoro, Luca Di Tommaso, Giuseppe Ingravallo, Laura Russo, Giorgio Da Rin, Anna Villa, Silvia Della Bella, Paolo Andrea Zucali, Domenico Mavilio

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Thymic epithelial tumors (TETs) are rare mediastinal cancers originating from the thymus, classified in two main histotypes: thymoma and thymic carcinoma (TC). TETs affect a primary lymphoid organ playing a critical role in keeping T-cell homeostasis

Externí odkaz: https://doaj.org/article/82ca357fe64d44e2bab8ed8d76fd1bce

Current Perspectives on Immunotherapy in the Peri-Operative Setting of Muscle-Infiltrating Bladder Cancer

Autor: Paolo Andrea Zucali, Nadia Cordua, Federica D'Antonio, Federica Borea, Matteo Perrino, Fabio De Vincenzo, Armando Santoro

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Patients with muscle-infiltrating bladder cancer (MIBC) present a high risk of postoperative recurrence and death from metastatic urothelial cancer despite surgical resection. Before the use of peri-operative chemotherapy, about half (52%) of patient

Externí odkaz: https://doaj.org/article/6e426517b80842318dd282b86332d017

SARS-CoV-2 vaccine in patients with thymic epithelial tumours with and without active or pre-existing autoimmune disorders: Brief report of a TYME network safety analysis

Autor: Federica Giugliano, Paolo A. Zucali, Giulia Galli, Zelmira Ballatore, Chiara Corti, Pamela T. Aliaga, Jacopo Uliano, Grazia Vivanet, Giuseppe Curigliano, Fabio Conforti, Paola Queirolo, Rossana Berardi, Sara Manglaviti, Giulia Apollonio, Matteo Perrino, Federica Borea, Federica D'Antonio, Marina C. Garassino, Tommaso De Pas

Publikováno v: European Journal of Cancer. 166:202-207

International guidelines recommend severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine for patients with cancer. A substantial risk of developing vaccine-related autoimmune toxicities could be hypothesised for patients with thymic ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da9f3d8e62028cdd6eb6beb2f29a45e
https://doi.org/10.1016/j.ejca.2022.02.011

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?

Autor: Federica Borea, Marika A. Franczak, Maria Garcia, Matteo Perrino, Nadia Cordua, Ryszard T. Smolenski, Godefridus J. Peters, Rafal Dziadziuszko, Armando Santoro, Paolo A. Zucali, Elisa Giovannetti

Publikováno v: Borea, F, Franczak, M A, Garcia, M, Perrino, M, Cordua, N, Smolenski, R T, Peters, G J, Dziadziuszko, R, Santoro, A, Zucali, P A & Giovannetti, E 2023, ' Target Therapy in Malignant Pleural Mesothelioma : Hope or Mirage? ', International Journal of Molecular Sciences, vol. 24, no. 11, 9165 . https://doi.org/10.3390/ijms24119165

Malignant Pleural Mesothelioma (MPM) is a rare neoplasm that is typically diagnosed in a locally advanced stage, making it not eligible for radical surgery and requiring systemic treatment. Chemotherapy with platinum compounds and pemetrexed has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfc6df430a1c1cf238e4d8bf74c79cf
https://doi.org/10.3390/ijms24119165

Systemic treatments for thymic tumors: a narrative review

Autor: Fabio De Vincenzo, Armando Santoro, Nadia Cordua, Paolo Andrea Zucali, Matteo Perrino, Federica Borea, Federica D'Antonio, Nunzio Digiacomo

Publikováno v: Mediastinum

Thymic epithelial tumours (TETs) are rare tumours originating from the thymus. Considering the rarity of this disease, the management of TETs is still challenging and difficult. In fact, all the worldwide clinical practice guidelines are based on dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd2a75d557d5ecc13d11b39f62a3846
https://doi.org/10.21037/med-21-11