Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells

Autor: Federica Aliotta, Rosarita Nasso, Rosario Rullo, Alessandro Arcucci, Angelica Avagliano, Martina Simonetti, Gennaro Sanità, Mariorosario Masullo, Antonio Lavecchia, Maria Rosaria Ruocco, Emmanuele De Vendittis

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1866-1878 (2020)

The dual phosphatases CDC25 are involved in cell cycle regulation and overexpressed in many tumours, including melanoma. CDC25 is a promising target for discovering anticancer drugs, and several studies focussed on characterisation of quinonoid CDC25

Externí odkaz: https://doaj.org/article/63270ce9b6af4f3cbaabe2d3845e181d

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines

Autor: Carmen Cerchia, 1, + Rosarita Nasso, 2, 4, + Matteo Mori, 3+ Stefania Villa, 3 Arianna Gelain3, Alessandra Capasso, 2 Federica Aliotta, 2 Martina Simonetti, 2 Rosario Rullo, 5 Mariorosario Masullo, 4 Emmanuele De Vendittis, 2 Maria Rosaria Ruocco, Antonio Lavecchia1

Publikováno v: Journal of medicinal chemistry (Online) 62 (2019): 7089–7110. doi:10.1021/acs.jmedchem.9b00632
info:cnr-pdr/source/autori:Carmen Cerchia,1,+ Rosarita Nasso,2,4,+ Matteo Mori,3+ Stefania Villa,3 Arianna Gelain3, Alessandra Capasso,2 Federica Aliotta,2 Martina Simonetti,2 Rosario Rullo,2,5 Mariorosario Masullo,4 Emmanuele De Vendittis,2 Maria Rosaria Ruocco,2,* Antonio Lavecchia1,*/titolo:Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism and in Vitro Efficacy against Melanoma Cell Lines/doi:10.1021%2Facs.jmedchem.9b00632/rivista:Journal of medicinal chemistry (Online)/anno:2019/pagina_da:7089/pagina_a:7110/intervallo_pagine:7089–7110/volume:62

CDC25 phosphatases play a critical role in the regulation of the cell cycle and thus represent attractive cancer therapeutic targets. We previously discovered the 4-(2-carboxybenzoyl)phthalic acid (NSC28620) as a new CDC25 inhibitor endowed with prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b17adad6ad0f8be4e1ff7846ce0e2e
https://doi.org/10.1021/acs.jmedchem.9b00632

Quinoa as source of type 1 ribosome inactivating proteins: A novel knowledge for a revision of its consumption

Autor: Rosarita Nasso, Antimo Di Maro, Nicola Landi, Federica Aliotta, Sara Ragucci, Paolo V. Pedone, Maria Rosaria Ruocco

This study investigates on the presence of toxic proteins in quinoa seeds. To this aim, a plethora of biochemical approaches were adopted for the purification and characterization of quinoin, a type 1 ribosome-inactivating protein (RIP) contained in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedfce265b7d62245004d17dd1aa4f7c
http://hdl.handle.net/11588/820900

Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells

Autor: Antonio Lavecchia, Rosario Rullo, Angelica Avagliano, Emmanuele De Vendittis, Mariorosario Masullo, Maria Rosaria Ruocco, Martina Simonetti, Gennaro Sanità, Alessandro Arcucci, Rosarita Nasso, Federica Aliotta

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1866-1878 (2020)

The dual phosphatases CDC25 are involved in cell cycle regulation and overexpressed in many tumours, including melanoma. CDC25 is a promising target for discovering anticancer drugs, and several studies focussed on characterisation of quinonoid CDC25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c0bdb4a6663304dfec7b07526fa4d0
http://hdl.handle.net/11367/86670

Development of a Stromal Microenvironment Experimental Model Containing Proto-Myofibroblast Like Cells and Analysis of Its Crosstalk with Melanoma Cells: A New Tool to Potentiate and Stabilize Tumor Suppressor Phenotype of Dermal Myofibroblasts

Autor: Claudio Bellevicine, Stefania Masone, Federica Aliotta, Rosarita Nasso, Mariorosario Masullo, Antonino Iaccarino, Alessandro Arcucci, Giuseppe Fiume, Gennaro Sanità, Angelica Avagliano, Gaetano Calì, Stefania Montagnani, Maria Rosaria Ruocco

Publikováno v: Cells 8 (2019). doi:10.3390/cells8111435
info:cnr-pdr/source/autori:Avagliano, Angelica; Ruocco, Maria Rosaria; Nasso, Rosarita; Aliotta, Federica; Sanita, Gennaro; Iaccarino, Antonino; Bellevicine, Claudio; Cali, Gaetano; Fiume, Giuseppe; Masone, Stefania; Masullo, Mariorosario; Montagnani, Stefania; Arcucci, Alessandro/titolo:Development of a Stromal Microenvironment Experimental Model Containing Proto-Myofibroblast Like Cells and Analysis of Its Crosstalk with Melanoma Cells: A New Tool to Potentiate and Stabilize Tumor Suppressor Phenotype of Dermal Myofibroblasts/doi:10.3390%2Fcells8111435/rivista:Cells/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Cells
Volume 8
Issue 11

Melanoma is one of the most aggressive solid tumors and includes a stromal microenvironment that regulates cancer growth and progression. The components of stromal microenvironment such as fibroblasts, fibroblast aggregates and cancer-associated fibr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8675c8d3cc92c216f067cf6721c09b5