Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Federica Cuozzo"'
Autor:
Federica Cuozzo, Katrina Viloria, Ali H. Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Jason Tong, Zicong Jiao, Adam Boufersaoui, Bryan Marzullo, Daniel B. Rosoff, Hannah R. Smith, Caroline Bonner, Julie Kerr-Conte, Francois Pattou, Rita Nano, Lorenzo Piemonti, Paul R.V. Johnson, Rebecca Spiers, Jennie Roberts, Gareth G. Lavery, Anne Clark, Carlo D.L. Ceresa, David W. Ray, Leanne Hodson, Amy P. Davies, Guy A. Rutter, Masaya Oshima, Raphaël Scharfmann, Matthew J. Merrins, Ildem Akerman, Daniel A. Tennant, Christian Ludwig, David J. Hodson
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114047- (2024)
Summary: Using 13C6 glucose labeling coupled to gas chromatography-mass spectrometry and 2D 1H-13C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell functi
Externí odkaz:
https://doaj.org/article/2e924f2360b54e9dbc6f6da13e566a04
Autor:
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Visualizing endogenous GPCRs is challenging. Here the authors generate mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, design fluorescent dyes for specific labelling in complex tissue, and reve
Externí odkaz:
https://doaj.org/article/a1c114f010cf4dc7bafcaf994b474beb
Autor:
Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.
Externí odkaz:
https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c
Autor:
Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The α-ketoglutarate–dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues. Although PHD3 has been reported to influence cancer cell metabolism and liver insulin se
Externí odkaz:
https://doaj.org/article/1bf081e6aea049debb7985fde804b9c9
Autor:
Katrina Viloria, Daniela Nasteska, Linford J.B. Briant, Silke Heising, Dean P. Larner, Nicholas H.F. Fine, Fiona B. Ashford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E. MacDonald, Ildem Akerman, Gareth G. Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, Martin Hewison, David J. Hodson
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107761- (2020)
Summary: Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although DBP serum levels,
Externí odkaz:
https://doaj.org/article/4961e1cbcd0b42b7a385bb7cadbfb0b4
Autor:
Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3107-3114 (2018)
Summary: Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic
Externí odkaz:
https://doaj.org/article/26706adfa2534c22a56f1079550fabca
Autor:
Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/babcfb71b6f54a778b28993243b49eed
Autor:
Federica Cuozzo, Katrina Viloria, Daniela Nasteska, Zicong Jiao, Hannah R. Smith, Caroline Bonner, Julie Kerr-Conte, Francois Pattou, Rita Nano, Lorenzo Piemonti, Jennie Roberts, Gareth G. Lavery, Anne Clark, Carlo Ceresa, Leanne Hodson, Amy Davies, Guy Rutter, Ildem Akerman, Daniel A. Tennant, Christian Ludwig, David Hodson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80325f585ad3c023f23f221e11be6180
https://doi.org/10.2139/ssrn.4398981
https://doi.org/10.2139/ssrn.4398981
Autor:
Federica Cuozzo, Daniela Nasteska, Zicong Jiao, Hannah R. Smith, Caroline Bonner, Julie Kerr-Conte, Francois Pattou, Rita Nano, Lorenzo Piemonti, Jennie Roberts, Gareth G. Lavery, Ildem Akerman, Daniel A. Tennant, Christian Ludwig, David J. Hodson
Using13C6glucose labeling coupled to GC-MS and 2D1H-13C HSQC NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning steady state insulin release and β cell function. In both mouse and human islets, the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c77e548212058b36324c91ca36307055
https://doi.org/10.1101/2022.12.21.521364
https://doi.org/10.1101/2022.12.21.521364
Autor:
Katrina Viloria, Daniela Nasteska, Julia Ast, Annie Hasib, Federica Cuozzo, Silke Heising, Linford J.B. Briant, Martin Hewison, David J. Hodson
GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in transport of circulating vitamin 25(OH)D and fatty acids, as well as actin-scavenging. In the pancreatic islets, the gene encoding GC, GC, is highly-localized to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afef49093356a6177f98dec0db2c8f8
https://doi.org/10.2337/figshare.21553317.v1
https://doi.org/10.2337/figshare.21553317.v1