Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Federica, Poggialini"'
Autor:
Giusy Tassone, Samuele Maramai, Marco Paolino, Stefania Lamponi, Federica Poggialini, Elena Dreassi, Elena Petricci, Stefano Alcaro, Cecilia Pozzi, Isabella Romeo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Bioconjugation is one of the most promising strategies to improve drug delivery, especially in cancer therapy. Biomolecules such as bile acids (BAs) have been intensively explored as carriers, due to their peculiar physicochemical properties
Externí odkaz:
https://doaj.org/article/1a4c84aa763544cdb95cf8741a3df437
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7588 (2024)
Globalization and climate change are both contributing to an increase in the number of potentially invasive algae in coastal areas. In terms of biodiversity and financial losses, the invasiveness of algae has become a significant issue in Orbetello L
Externí odkaz:
https://doaj.org/article/1280146da9424cde821d3a1fe1262157
Autor:
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Silvia Filippi, Eleonora Mancin, Lia Fiaschi, Elisa De Marchi, Federica Giammarino, Chiara Vagaggini, Bruno Mattia Bizzarri, Raffaele Saladino, Elena Dreassi, Maurizio Zazzi, Lorenzo Botta
Publikováno v:
Molecules, Vol 29, Iss 7, p 1452 (2024)
The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development. Scaffold decoration, morphing and hopping are additional techniques that enable
Externí odkaz:
https://doaj.org/article/e3ec79e5c0fa472db93d562a43145464
Autor:
Luisa Maresca, Enrica Crivaro, Francesca Migliorini, Giulia Anichini, Alessandro Giammona, Sara Pepe, Federica Poggialini, Chiara Vagaggini, Giuseppe Giannini, Serena Sestini, Lorenzo Borgognoni, Andrea Lapucci, Elena Dreassi, Maurizio Taddei, Fabrizio Manetti, Elena Petricci, Barbara Stecca
Publikováno v:
Pharmacological Research, Vol 195, Iss , Pp 106858- (2023)
Aberrant activation of Hedgehog (HH) signaling in cancer is the result of genetic alterations of upstream pathway components (canonical) or other oncogenic mechanisms (noncanonical), that ultimately concur to activate the zinc-finger transcription fa
Externí odkaz:
https://doaj.org/article/3edd0903f8c04391913aff178e1c0782
Publikováno v:
Chemistry, Vol 4, Iss 4, Pp 1714-1722 (2022)
A single clean, good-yielding, environment-friendly microwave-assisted procedure for O-silylation of uridine with tert-butyldimethylsilyl chloride (TBDMSCl), 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) and potassium nitrate as catalyst under solvent-fre
Externí odkaz:
https://doaj.org/article/d40d8606b78c4392ae37610bfd191298
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Anna Carbone, Francesca Musumeci, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1527 (2023)
Although patients would rather oral therapies to injections, the gastrointestinal tract’s low permeability makes this method limiting for most compounds, including anticancer drugs. Due to their low bioavailability, oral antitumor therapies suffer
Externí odkaz:
https://doaj.org/article/0c24052588a24c2d985bde16104856df
Autor:
Annalaura Brai, Federica Poggialini, Claudia Pasqualini, Claudia Immacolata Trivisani, Chiara Vagaggini, Elena Dreassi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9225 (2023)
In recent decades, vaccines have been extraordinary resources to prevent pathogen diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or more adjuvants represents the key to enhance the response of the immune sig
Externí odkaz:
https://doaj.org/article/e8ed2cb130f6409a99722f7a46ee8552
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci, Maria Frosini, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 453 (2023)
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual
Externí odkaz:
https://doaj.org/article/ccd671932b5b41839203be632d83a138
Autor:
Annalaura Brai, Federica Poggialini, Chiara Vagaggini, Claudia Pasqualini, Sauro Simoni, Valeria Francardi, Elena Dreassi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2296 (2023)
The progression of drugs into clinical phases requires proper toxicity assessment in animals and the correct identification of possible metabolites. Accordingly, different animal models are used to preliminarily evaluate toxicity and biotransformatio
Externí odkaz:
https://doaj.org/article/621fe1bc881a433e8b3ca76658eb7247
Autor:
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Massimiliano Secchi, Federica Giammarino, Ilenia Varasi, Camilla Lodola, Maurizio Zazzi, Elena Dreassi, Giovanni Maga, Lorenzo Botta, Raffaele Saladino
Publikováno v:
Molecules, Vol 27, Iss 24, p 8829 (2022)
Current therapy against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are based on the use of Remdesivir 1, Molnupiravir 2, and the recently identified Nirmatrelvir 3. Unfortunately, these three drugs showed some limitations regar
Externí odkaz:
https://doaj.org/article/c0abea2af9b042f980b54cd2f982ba34