A genome-wide association study identifies five loci influencing facial morphology in Europeans.

Autor: Fan Liu, Fedde van der Lijn, Claudia Schurmann, Gu Zhu, M Mallar Chakravarty, Pirro G Hysi, Andreas Wollstein, Oscar Lao, Marleen de Bruijne, M Arfan Ikram, Aad van der Lugt, Fernando Rivadeneira, André G Uitterlinden, Albert Hofman, Wiro J Niessen, Georg Homuth, Greig de Zubicaray, Katie L McMahon, Paul M Thompson, Amro Daboul, Ralf Puls, Katrin Hegenscheid, Liisa Bevan, Zdenka Pausova, Sarah E Medland, Grant W Montgomery, Margaret J Wright, Carol Wicking, Stefan Boehringer, Timothy D Spector, Tomáš Paus, Nicholas G Martin, Reiner Biffar, Manfred Kayser

Publikováno v: PLoS Genetics, Vol 8, Iss 9, p e1002932 (2012)

Inter-individual variation in facial shape is one of the most noticeable phenotypes in humans, and it is clearly under genetic regulation; however, almost nothing is known about the genetic basis of normal human facial morphology. We therefore conduc

Externí odkaz: https://doaj.org/article/06abf74d128b48468ca0ac2ca25ea53e

The role of the posterior fossa in developing Chiari I malformation in children with craniosynostosis syndromes

Autor: Johan de Rooi, Maarten H. Lequin, Wiro J. Niessen, Marie-Lise Charlotte van Veelen-Vincent, Fedde van der Lijn, Yoo Young Hoogendam, Irene M. J. Mathijssen, B. F. M. Rijken

Publikováno v: Journal of Cranio-Maxillofacial Surgery, 43(6), 813-819. Churchill Livingstone

Objective: Patients with craniosynostosis syndromes are at risk of increased intracranial pressure (ICP) and Chiari I malformation (CMI), caused by a combination of restricted skull growth, venous hypertension, obstructive sleep apnea (OSA), and an o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fb75ca776f42acd5776700472cf9af
https://doi.org/10.1016/j.jcms.2015.04.001

The influence of cerebral small vessel disease on default mode network deactivation in mild cognitive impairment

Autor: Tom den Heijer, John C. van Swieten, Fedde van der Lijn, Peter J. Koudstaal, Francesco U.S. Mattace-Raso, Marion Smits, Janne M. Papma, Aad van der Lugt, Niels D. Prins, Inge de Koning

Publikováno v: NeuroImage : Clinical
NeuroImage, 2, 33-42. Academic Press

IntroductionCerebral small vessel disease (CSVD) is thought to contribute to cognitive dysfunction in patients with mild cognitive impairment (MCI). The underlying mechanisms, and more specifically, the effects of CSVD on brain functioning in MCI are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e792725c212f21259294e5f0147c028e
https://doi.org/10.1016/j.nicl.2012.11.005

Automated Brain Structure Segmentation Based on Atlas Registration and Appearance Models

Autor: Wiro J. Niessen, Fedde van der Lijn, M. de Bruijne, Tom den Heijer, A. van der Lugt, Stefan Klein, Yoo Young Hoogendam, Monique M.B. Breteler

Publikováno v: IEEE transactions on medical imaging 31(2), 276-286 (2012). doi:10.1109/TMI.2011.2168420
IEEE Transactions on Medical Imaging, 31(2), 276-286. Institute of Electrical and Electronics Engineers Inc.

Accurate automated brain structure segmentation methods facilitate the analysis of large-scale neuroimaging studies. This work describes a novel method for brain structure segmentation in magnetic resonance images that combines information about a st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e855979a77c47b336648a872a917e2
https://doi.org/10.1109/tmi.2011.2168420

Vascular risk factors, apolipoprotein E, and hippocampal decline on magnetic resonance imaging over a 10-year follow-up

Autor: Monique M.B. Breteler, Gabriel P. Krestin, Wiro J. Niessen, Aad van der Lugt, Henri A. Vrooman, Arfan Ikram, Fedde van der Lijn, Peter J. Koudstaal, Tom den Heijer, Albert Hofman

Publikováno v: Alzheimers & Dementia, 8(5), 417-425. Elsevier Inc.

Background: Decline of hippocampal volume on magnetic resonance imaging (MRI) may be considered as a surrogate biomarker of accumulating Alzheimer disease (AD) pathology. Previously, we showed in the prospective population-based Rotterdam Scan Study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ce6f5096aa64778874193c95a52cee
https://hdl.handle.net/1765/34998