Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Feda H. Hamdan"'
Autor:
Zhe Zhang, Xin Wang, Feda H. Hamdan, Anna Likhobabina, Shilpa Patil, Lena Aperdannier, Madhobi Sen, Jacobe Traub, Albrecht Neesse, André Fischer, Argyris Papantonis, Shiv K. Singh, Volker Ellenrieder, Steven A. Johnsen, Elisabeth Hessmann
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 5, Pp 1219-1246 (2023)
Background & Aims: Loss of AT-rich interactive domain-containing protein 1A (ARID1A) fosters acinar-to-ductal metaplasia (ADM) and pancreatic carcinogenesis by down-regulating transcription programs controlling acinar cell identity. However, how ARID
Externí odkaz:
https://doaj.org/article/eb30d11bebe1451192c01dfee4b0bc4b
Autor:
Kirsten G. M. Aspros, Jodi M. Carter, Tanya L. Hoskin, Vera J. Suman, Malayannan Subramaniam, Michael J. Emch, Zhenqing Ye, Zhifu Sun, Jason P. Sinnwell, Kevin J. Thompson, Xiaojia Tang, Esther P. B. Rodman, Xiyin Wang, Adam W. Nelson, Igor Chernukhin, Feda H. Hamdan, Elizabeth S. Bruinsma, Jason S. Carroll, Martin E. Fernandez-Zapico, Steven A. Johnsen, Krishna R. Kalari, Haojie Huang, Roberto A. Leon-Ferre, Fergus J. Couch, James N. Ingle, Matthew P. Goetz, John R. Hawse
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Triple Negative Breast Cancer (TNBC) accounts for 15–20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities. Thus, there is an urgent need to identify novel biomarkers and t
Externí odkaz:
https://doaj.org/article/cb14a3f8cc2f47efa372c800d589e31a
Autor:
Nidhi Jalan‐Sakrikar, Thiago M. De Assuncao, Amaia Navarro‐Corcuera, Feda H. Hamdan, Lorena Loarca, Lindsey A. Kirkeby, Zachary T. Resch, Steven P. O’Hara, Brian D. Juran, Konstantinos N. Lazaridis, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Vijay H. Shah, Nicholas F. LaRusso, Robert C. Huebert
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 345-360 (2022)
Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetica
Externí odkaz:
https://doaj.org/article/ca9f01c370f541249f03d813d0b08950
Autor:
Mengfei Liu, Sheng Cao, Li He, Jinhang Gao, Juan P. Arab, Huarui Cui, Weixia Xuan, Yandong Gao, Tejasav S. Sehrawat, Feda H. Hamdan, Meritxell Ventura-Cots, Josepmaria Argemi, William C. K. Pomerantz, Steven A. Johnsen, Jeong-Heon Lee, Fei Gao, Tamas Ordog, Philippe Mathurin, Alexander Revzin, Ramon Bataller, Huihuang Yan, Vijay H. Shah
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Alcoholic hepatitis is characterized by intense liver inflammation driven by excessive cytokines and chemokines production and immune cell infiltration. Here the authors identify a super-enhancer that regulates the expression of multiple CXCL chemoki
Externí odkaz:
https://doaj.org/article/00c1cb666647413b9cdcbd808e6d8ec6
Autor:
Melanie S. Patzak, Vijayalakshmi Kari, Shilpa Patil, Feda H. Hamdan, Robert G. Goetze, Marius Brunner, Jochen Gaedcke, Julia Kitz, Duncan I. Jodrell, Frances M. Richards, Christian Pilarsky, Robert Gruetzmann, Petra Rümmele, Thomas Knösel, Elisabeth Hessmann, Volker Ellenrieder, Steven A. Johnsen, Albrecht Neesse
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 394-405 (2019)
Background: Cytosolic 5′-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Here, we investigate NT5C1A expression in pancreatic ductal adenocarcinoma (PDAC) and its impac
Externí odkaz:
https://doaj.org/article/195147ef850549bba1a4da0c7a0248e9
Publikováno v:
Cells, Vol 10, Iss 5, p 966 (2021)
Pancreatic ductal adenocarcinoma (PDAC) displays a particularly poor prognosis and low survival rate, mainly due to late diagnosis and high incidence of chemotherapy resistance. Genomic aberrations, together with changes in the epigenomic profile, el
Externí odkaz:
https://doaj.org/article/4ffc2d492d254d398daed843fc3747bf
Autor:
Hannah Flebbe, Feda H. Hamdan, Vijayalakshmi Kari, Julia Kitz, Jochen Gaedcke, B. Michael Ghadimi, Steven A. Johnsen, Marian Grade
Publikováno v:
Cancers, Vol 11, Iss 8, p 1142 (2019)
Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin immunoprecipitation (ChIP) followed by next-generation sequencing (
Externí odkaz:
https://doaj.org/article/220b3fb9a3004f02813fecead7284214
Autor:
Feda H. Hamdan, Steven A. Johnsen
Publikováno v:
Cancers, Vol 11, Iss 5, p 634 (2019)
Tight regulation of gene transcription is essential for normal development, tissue homeostasis, and disease-free survival. Enhancers are distal regulatory elements in the genome that provide specificity to gene expression programs and are frequently
Externí odkaz:
https://doaj.org/article/6f0c9fc991584888acf1a9e80207765c
Autor:
Feda H. Hamdan, Steven A. Johnsen
Publikováno v:
Epigenomes, Vol 2, Iss 2, p 8 (2018)
While the mortality rates of cancer are generally declining, pancreatic cancer persists to be an exception with a 5-year-survival rate of less than 7%. Late diagnosis and resistance to conventional therapies contribute to high mortality rates in spit
Externí odkaz:
https://doaj.org/article/3fe93699014b4f35a7ecd64efb3f16ba
Autor:
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen
Publikováno v:
Gut. 72:1174-1185
ObjectivePancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel