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Akademický článek

Reduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia.

Autor: Raeker MÖ; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA., Perera ND; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA., Karoukis AJ; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA., Chen L; Department of Orthopedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA., Feathers KL; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA., Ali RR; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.; KCL Center for Cell and Gene Therapy, London WC2R 2LS, UK., Thompson DA; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA., Fahim AT; Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.

Publikováno v: Cells [Cells] 2024 Jun 19; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 19.

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Akademický článek

Gene Supplementation in Mice Heterozygous for the D477G RPE65 Variant Implicated in Autosomal Dominant Retinitis Pigmentosa.

Autor: Feathers KL; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA., Jia L; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA., Khan NW; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA., Smith AJ; Centre for Stem Cells & Regenerative Medicine, King's College London, London, United Kingdom., Ma JX; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Ali RR; Centre for Stem Cells & Regenerative Medicine, King's College London, London, United Kingdom., Thompson DA; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Publikováno v: Human gene therapy [Hum Gene Ther] 2023 Jul; Vol. 34 (13-14), pp. 639-648. Date of Electronic Publication: 2023 May 16.

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Akademický článek

Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells.

Autor: Chen L; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA., Perera ND; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA., Karoukis AJ; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA., Feathers KL; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA., Ali RR; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.; KCL Centre for Cell and Gene Therapy, London, WC2R 2LS, England, UK., Thompson DA; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48105, USA., Fahim AT; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA. ahteich@med.umich.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Jul 26; Vol. 12 (1), pp. 12694. Date of Electronic Publication: 2022 Jul 26.

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Akademický článek

Detailed clinical characterisation, unique features and natural history of autosomal recessive RDH12 -associated retinal degeneration.

Autor: Fahim AT; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA ahteich@med.umich.edu., Bouzia Z; Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK., Branham KH; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA., Kumaran N; Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK., Vargas ME; Department of Ophthalmology, Oregon Health & Science University - Casey Eye Institute, Portland, Oregon, USA., Feathers KL; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA., Perera ND; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA., Young K; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA., Khan NW; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA., Heckenlively JR; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA., Webster AR; Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK., Pennesi ME; Department of Ophthalmology, Oregon Health & Science University - Casey Eye Institute, Portland, Oregon, USA., Ali RR; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.; Institute of Ophthalmology, University College London, London, UK., Thompson DA; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Michaelides M; Moorfields Eye Hospital NHS Foundation Trust, London, UK.; Institute of Ophthalmology, University College London, London, UK.

Publikováno v: The British journal of ophthalmology [Br J Ophthalmol] 2019 Dec; Vol. 103 (12), pp. 1789-1796. Date of Electronic Publication: 2019 Apr 12.

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Akademický článek

Development of a Gene Therapy Vector for RDH12 -Associated Retinal Dystrophy.

Autor: Feathers KL; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Jia L; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Perera ND; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Chen A; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Presswalla FK; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Khan NW; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Fahim AT; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan., Smith AJ; Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom., Ali RR; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan.; Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom., Thompson DA; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan.; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan.

Publikováno v: Human gene therapy [Hum Gene Ther] 2019 Nov; Vol. 30 (11), pp. 1325-1335. Date of Electronic Publication: 2019 Aug 05.

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Akademický článek

MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.

Autor: Shelby SJ; Department of Biological Chemistry, University of Michigan Medical School, 1150 W. Medical Center Dr., Ann Arbor, MI 48109, USA; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI 48105, USA., Feathers KL; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI 48105, USA., Ganios AM; Department of Biological Chemistry, University of Michigan Medical School, 1150 W. Medical Center Dr., Ann Arbor, MI 48109, USA., Jia L; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI 48105, USA., Miller JM; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI 48105, USA., Thompson DA; Department of Biological Chemistry, University of Michigan Medical School, 1150 W. Medical Center Dr., Ann Arbor, MI 48109, USA; Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI 48105, USA. Electronic address: dathom@umich.edu.

Publikováno v: Experimental eye research [Exp Eye Res] 2015 Nov; Vol. 140, pp. 28-40. Date of Electronic Publication: 2015 Aug 15.

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