Accessing opioid agonist treatment in prison in England and Scotland remains problematic – the views of people with lived experience

Autor: Webster, Russell, Fearns, Colin, Harriott, Paula, Millar, Lisa, Simpson, Jardine, Wallace, Jason, Wheatley, Michael

Publikováno v: International Journal of Prison Health, 2023, Vol. 20, Issue 2, pp. 143-155.

Externí odkaz: http://www.emeraldinsight.com/doi/10.1108/IJOPH-05-2023-0025

JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase

Autor: Bonneux, Brecht, Shareef, Afzaal, Tcherniuk, Sergey, Anson, Brandon, de Bruyn, Suzanne, Verheyen, Nick, Thys, Kim, Conceição-Neto, Nádia, Van Ginderen, Marcia, Kwanten, Leen, Ysebaert, Nina, Vranckx, Luc, Peeters, Elien, Lanckacker, Ellen, Gallup, Jack M., Sitthicharoenchai, Panchan, Alnajjar, Sarhad, Ackermann, Mark R., Adhikary, Suraj, Bhaumik, Anusarka, Patrick, Aaron, Fung, Amy, Sutto-Ortiz, Priscila, Decroly, Etienne, Mason, Stephen W., Lançois, David, Deval, Jerome, Jin, Zhinan, Eléouët, Jean-François, Fearns, Rachel, Koul, Anil, Roymans, Dirk, Rigaux, Peter, Herschke, Florence

Publikováno v: In Antiviral Research July 2024 227

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Autor: Victoria A. Kleiner, Thierry O. Fischmann, John A. Howe, Douglas C. Beshore, Michael J. Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D. Nahas, Bob J. Lucas, He Xi, Edward Murray, Daphne Y. Ma, Krista Getty, Rachel Fearns

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

Abstract Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and resulting disease in infants, elderly, and immunocompromised adults1–3. Therapeutic small molecule

Externí odkaz: https://doaj.org/article/b774cd14df994f13b41ff196588a5489

Early-Life Outcomes in Relation to Social Determinants of Health for Children Born Extremely Preterm

Autor: Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Bishop, Carmena, Burke, Robert T., Caskey, Melinda, Hoffman, Laurie, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Lamberson, Vita, Leach, Teresa M., Little, Emilee, McGowan, Elisabeth C., Stephens, Bonnie E., Vieira, Elisa, St. Pierre, Lucille, Ventura, Suzy, Watson, Victoria E., Hibbs, Anna Maria, Walsh, Michele C., Wilson-Costello, Deanne E., Newman, Nancy S., Bhola, Monika, Payne, Allison H., Siner, Bonnie S., Yalcinkaya, Gulgun, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Scott, Allison, Parimi, Prabhu S., Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Donovan, Edward F., Merhar, Stephanie, Grisby, Cathy, Yolton, Kimberly, Alexander, Barbara, Beiersdorfer, Traci, Bridges, Kate, Cahill, Tanya E., Dudley, Juanita, Fischer, Estelle E., Gratton, Teresa L., Hayes, Devan, Hessling, Jody, Jackson, Lenora D., Kirker, Kristin, Mincey, Holly L., Muthig, Greg, Stacey, Sara, Steichen, Jean J., Tepe, Stacey, Thompson, Julia, Wuertz, Sandra, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Mago-Shah, Deesha, Ashley, Patricia L., Finkle, Joanne, Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Talbert, Jennifer, Warner, Diane, Trembath, Andrea, O'Shea, T. Michael, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne C., Adams-Chapman, Ira, Blackwelder, Ann, Bottcher, Diane I., Carter, Sheena L., Kendrick-Allwood, Salathiel, Laursen, Judith, LaRossa, Maureen Mulligan, Mackie, Colleen, Sanders, Amy, Seabrook, Irma, Smikle, Gloria, Wineski, Lynn C., Higgins, Rosemary D., Bremer, Andrew A., Archer, Stephanie Wilson, Sokol, Gregory M., Dusick, Anna M., Papile, Lu Ann, Gunn, Susan, Hamer, Faithe, Harmon, Heidi M., Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Miller, Lucy C., Minnich, Heike M., Richard, Leslie, Smiley, Lucy, Wilson, Leslie Dawn, Tyson, Jon E., Kennedy, Kathleen A., Khan, Amir M., Duncan, Andrea, Mosquera, Ricardo, Stephens, Emily K., McDavid, Georgia E., Alaniz, Nora I., Allain, Elizabeth, Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Eason, Elizabeth, Evans, Patricia W., Garcia, Carmen, Green, Charles, Hall, Donna, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Lis, Anna E., Martin, Karen, Martin, Sara C., Mason, Carrie M., McKee, Shannon, Morris, Brenda H., Rennie, Kimberly, Rodgers, Shawna, Siddiki, Saba Khan, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Slaughter, Jonathan L., Yeates, Keith O., Keim, Sarah, Maitre, Nathalie L., Timan, Christopher J., Luzader, Patricia, Clark, Erna, Fortney, Christine A., Gutentag, Julie, Park, Courtney, Shadd, Julie, Sullivan, Margaret, Stein, Melanie, Nelin, Mary Ann, Newton, Julia, Small, Kristi, Burkhardt, Stephanie, Purnell, Jessica, Pietruszewski, Lindsay, Levengood, Katelyn, Batterson, Nancy, Morehead, Pamela, Carey, Helen, Yoseff-Salameh, Lina, Sullivan, Rox Ann, Hague, Cole, Grothause, Jennifer, Fearns, Erin, Fowler, Aubrey, Notestine, Jennifer, Tonneman, Jill, Hay, Krystal, Chao, Michelle, Warnimont, Kyrstin, Marzec, Laura, Miller, Bethany, Beckford, Demi R., Baugher, Hallie, DeSantis, Brittany, Hanlon, Cory, McCool, Jacqueline, Das, Abhik, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Crawford, Margaret M., Gabrio, Jenna, Leblond, David, Newman, Jamie E., Petrie Huitema, Carolyn M., O'Donnell Auman, Jeanette, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, Bruno, Elizabeth, Davis, Alexis S., Elena DeAnda, Maria, DeBattista, Anne M., Huffman, Lynne C., Ismael, Magdy, Kohn, Jean G., Krueger, Casey, Lowe, Janice, Lucash, Ryan E., Palmquist, Andrew W., Patel, Jessica, Proud, Melinda S., Reichert, Elizabeth N., John, Nicholas H. St., Sivakumar, Dharshi, Taylor, Heather L., Wager, Natalie, Williams, R. Jordan, Weiss, Hali, Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Church, Paige T., Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Nelson, Kathleen G., Bailey, Kirstin J., Biasini, Fred J., Chopko, Stephanie A., Collins, Monica V., Cosby, Shirley S., Johnston, Kristen C., Moses, Mary Beth, Patterson, Cryshelle S., Phillips, Vivien A., Preskitt, Julie, Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Brumbaugh, Jane E., Acarregui, Michael J., Johnson, Karen J., Eastman, Diane L., Goeke, Claire A., Schmelzel, Mendi L., Walker, Jacky R., Baack, Michelle L., Hogden, Laurie A., Broadbent, Megan, Elenkiwich, Chelsey, Henning, Megan M., Van Muyden, Sarah, Ellsbury, Dan L., Campbell, Donia B., Tud, Tracy L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Fuller, Janell, Ohls, Robin K., Beauman, Sandra Sundquist, Lacy, Conra Backstrom, Duncan, Andrea F., Hanson, Mary, Hartenberger, Carol, Kuan, Elizabeth, Lowe, Jean R., Thomson, Rebecca A., DeMauro, Sara B., Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Catts, Christine, Cook, Noah, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Ghavam, Sarvin, Hurt, Hallam, Snyder, Jonathan, Vangala, Saritha, Ziolkowski, Kristina, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Myers, Gary J., Andrews-Hartley, Michelle, Johnson, Julie Babish, Binion, Kyle, Bowman, Melissa, Boylin, Elizabeth, Burnell, Erica, Coleman, Kelly R., Fallone, Cait, Farooq, Osman, Hunn, Julianne, Hust, Diane, Jensen, Rosemary L., Jones, Rachel, Kachelmeyer, Jennifer, Kushner, Emily, Maffett, Deanna, McKee, Kimberly G., Merzbach, Joan, Orme, Constance, Prinzing, Diane, Reubens, Linda J., Rochez, Daisy, Rowan, Mary, Sabaratnam, Premini, Scorsone, Ann Marie, Wadkins, Holly I.M., Yost, Kelley, Zwetsch, Lauren, Lakshminrusimha, Satyan, Reynolds, Anne Marie, Sacilowski, Michael G., Guilford, Stephanie, Li, Emily, Williams, Ashley, Zorn, William A., Wyckoff, Myra H., Brion, Luc P., Salhab, Walid A., Rosenfeld, Charles R., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Francis, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., McDougald, E. Rebecca, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Sepulveda, Pollieanna, Tolentino-Plata, Kristine, Boatman, Cathy Twell, Vera, Azucena, Waterbury, Jillian, Yoder, Bradley A., Baserga, Mariana, Faix, Roger G., Winter, Sarah, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Cole-Bledsoe, Laura, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Jordan, Jamie, Marchant, Trisha, Maxson, Earl, McGrath, Kandace M., Osborne, Karen A., Parry, D. Melody, Reich, Brixen A., Schaefer, Susan T., Spencer, Cynthia, Steffen, Michael, Tice, Katherine, Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Zanetti, Karen, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Natarajan, Girija, Pappas, Athina, Abramczyk, Katherine, Agarwal, Prashant, Bajaj, Monika, Bara, Rebecca, Billian, Elizabeth, Chawla, Sanjay, Childs, Kirsten, De Jesus, Lilia C., Driscoll, Debra, February, Melissa, Goldston, Laura A., Johnson, Mary E., Muran, Geraldine, Panaitescu, Bogdan, Prentiss, Jeannette E., White, Diane, Woldt, Eunice, Barks, John, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha D., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Vohr, Betty R., Travers, Colm P., Hintz, Susan R.

Publikováno v: In The Journal of Pediatrics August 2023 259

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Autor: Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M. Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I. MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano G. Gutierrez

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Extensive lysosomal damage can result in cell death but how limited protease leakage affects cytoplasmic organelles in viable cells is not well understood. Here the authors show that limited lysosomal damage leads to changes in the mitochondrial prot

Externí odkaz: https://doaj.org/article/1b0eea4b126e4d9fbd71cb879e06a954