VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

Autor: Fearnley, GW, Smith, GA, Abdul Zani, I, Yuldasheva, N, Mughal, NA, Homer-Vanniasinkam, S, Kearney, MT, Zachary, IC, Tomlinson, DC, Harrison, MA, Wheatcroft, SB, Ponnambalam, S

Publikováno v: Biology Open, Vol 5, Iss 5, Pp 571-583 (2016)

Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9717122cfdfa75ae377a8f1cf4716b9d
http://bio.biologists.org/content/5/5/571

VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8

Autor: Smith, GA, Fearnley, GW, Zani, IA, Wheatcroft, SB, Tomlinson, DC, Harrison, MA, Ponnambalam, S

Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e82a36b1438e4ffa5d99190d9388fcd8
https://eprints.whiterose.ac.uk/90882/13/Smith_et_al-2016-Traffic.pdf

The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression.

Autor: Young KA; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK., Wojdyla K; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK., Lai T; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK., Mulholland KE; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK., Aldaz Casanova S; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK., Antrobus R; Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK., Andrews SR; Bioinformatics, Babraham Institute, Cambridge CB22 3AT, UK., Biggins L; Bioinformatics, Babraham Institute, Cambridge CB22 3AT, UK., Mahler-Araujo B; Histopathology, Cambridge University Hospitals, Cambridge CB2 0QQ, UK., Barton PR; Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK., Anderson KR; Molecular biology department, Genentech, South San Francisco, CA 94080, USA., Fearnley GW; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK., Sharpe HJ; Signalling programme, Babraham Institute, Cambridge CB22 3AT, UK.

Publikováno v: Journal of cell science [J Cell Sci] 2024 Jul 15; Vol. 137 (14). Date of Electronic Publication: 2024 Jul 22.

ATF-2 and Tpl2 regulation of endothelial cell cycle progression and apoptosis.

Autor: Fearnley GW; School of Molecular & Cellular Biology, University of Leeds, UK., Latham AM; School of Molecular & Cellular Biology, University of Leeds, UK., Hollstein M; Faculty of Medicine & Health, University of Leeds, UK., Odell AF; Leeds Institute of Medical Research at St James's, University of Leeds, UK; School of Health Sciences, York St. John University, Lord Mayor's Walk, York, UK., Ponnambalam S; School of Molecular & Cellular Biology, University of Leeds, UK. Electronic address: s.ponnambalam@leeds.ac.uk.

Publikováno v: Cellular signalling [Cell Signal] 2020 Feb; Vol. 66, pp. 109481. Date of Electronic Publication: 2019 Nov 21.

IL-36γ Is a Strong Inducer of IL-23 in Psoriatic Cells and Activates Angiogenesis.

Autor: Bridgewood C; Centre of Skin Sciences, School of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom., Fearnley GW; Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Berekmeri A; Department of Dermatology, Chapel Allerton Hospital, Leeds, United Kingdom.; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Laws P; Department of Dermatology, Chapel Allerton Hospital, Leeds, United Kingdom.; National Institute of Health Research (NIHR), Leeds Biomedical Research Centre (BRC), Chapel Allerton Hospital, Leeds, United Kingdom., Macleod T; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Ponnambalam S; Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Stacey M; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Graham A; Biomedical Sciences, School of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom., Wittmann M; Centre of Skin Sciences, School of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom.; National Institute of Health Research (NIHR), Leeds Biomedical Research Centre (BRC), Chapel Allerton Hospital, Leeds, United Kingdom.; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2018 Feb 26; Vol. 9, pp. 200. Date of Electronic Publication: 2018 Feb 26 (Print Publication: 2018).