Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease

Autor: Gómez-Suaga, P., Fdez, E., Fernández, B., Martínez-Salvador, M., Blanca Ramírez, M., Madero-Pérez, J., Rivero-Ríos, P., Fuentes, J.M., Hilfiker, S.

Publikováno v: In Neuropharmacology October 2014 85:45-56

Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB.

Autor: Fernández B; Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), 18016, Granada, Spain., Olmedo P; Department of Legal Medicine and Toxicology, School of Medicine, University of 18016 Granada, Granada, Spain., Gil F; Department of Legal Medicine and Toxicology, School of Medicine, University of 18016 Granada, Granada, Spain., Fdez E; Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), 18016, Granada, Spain., Naaldijk Y; Department of Anesthesiology and Department of Physiology, Pharmacology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Rivero-Ríos P; Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA., Bracher F; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-University, 81377, Munich, Germany., Grimm C; Walther Straub Institute of Pharmacology and Toxicology Faculty of Medicine, Ludwig-Maximilians-Universitaet, 80336, Munich, Germany., Churchill GC; Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK., Hilfiker S; Department of Anesthesiology and Department of Physiology, Pharmacology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA. sabine.hilfiker@rutgers.edu.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Dec 16; Vol. 13 (12), pp. 1047. Date of Electronic Publication: 2022 Dec 16.

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.

Autor: Lara Ordóñez AJ; Department of Molecular Biology, Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), 18016 Granada, Spain., Fasiczka R; Department of Anesthesiology and Department of Physiology, Pharmacology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA., Fernández B; Department of Molecular Biology, Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), 18016 Granada, Spain., Naaldijk Y; Department of Anesthesiology and Department of Physiology, Pharmacology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA., Fdez E; Department of Molecular Biology, Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), 18016 Granada, Spain., Blanca Ramírez M; Department of Molecular Biology, Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), 18016 Granada, Spain., Phan S; Department of Neurosciences and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093, USA., Boassa D; Department of Neurosciences and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093, USA., Hilfiker S; Department of Anesthesiology and Department of Physiology, Pharmacology and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.

Publikováno v: Biology open [Biol Open] 2022 Aug 15; Vol. 11 (8). Date of Electronic Publication: 2022 Jul 29.

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.

Autor: Fernández B; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain., Chittoor-Vinod VG; Department of Pathology, Stanford University, Stanford, CA, USA., Kluss JH; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Kelly K; Duke Center for Neurodegeneration Research, Department of Pharmacology, Duke University, Durham, NC, USA., Bryant N; Duke Center for Neurodegeneration Research, Department of Pharmacology, Duke University, Durham, NC, USA., Nguyen APT; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA., Bukhari SA; Department of Pathology, Stanford University, Stanford, CA, USA., Smith N; Department of Biochemistry, Redox Biology Center, The University of Nebraska-Lincoln, NE, USA., Lara Ordóñez AJ; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain., Fdez E; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain., Chartier-Harlin MC; Univ. Lille, INSERM, CHU Lille, UMR-S, LilNCog - Centre de Recherche Lille Neurosciences & Cognition, Lille, France., Montine TJ; Department of Pathology, Stanford University, Stanford, CA, USA., Wilson MA; Department of Biochemistry, Redox Biology Center, The University of Nebraska-Lincoln, NE, USA., Moore DJ; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA., West AB; Duke Center for Neurodegeneration Research, Department of Pharmacology, Duke University, Durham, NC, USA., Cookson MR; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Nichols RJ; Department of Pathology, Stanford University, Stanford, CA, USA., Hilfiker S; Department of Anesthesiology and Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA.

Publikováno v: Journal of Parkinson's disease [J Parkinsons Dis] 2022; Vol. 12 (5), pp. 1423-1447.

Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations.

Autor: Rivero-Ríos P; Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), Avda del Conocimiento s/n, 18016 Granada, Spain.; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Romo-Lozano M; Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), Avda del Conocimiento s/n, 18016 Granada, Spain., Fernández B; Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), Avda del Conocimiento s/n, 18016 Granada, Spain., Fdez E; Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), Avda del Conocimiento s/n, 18016 Granada, Spain., Hilfiker S; Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.

Publikováno v: Cells [Cells] 2020 Jul 17; Vol. 9 (7). Date of Electronic Publication: 2020 Jul 17.