Výsledky vyhledávání - "Fd, Finkelman"

B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite

Autor: Rj, Greenwald, Joseph Urban, Mj, Ekkens, Chen S, Nguyen D, Fang H, Fd, Finkelman, Ah, Sharpe, Wc, Gause

Publikováno v: Europe PubMed Central

T cells require CD28/CTLA-4 costimulatory molecule interactions in addition to Ag-specific signals through the TCR for in vivo effector Th cell function. Some studies have suggested that the ligands for these costimulatory molecules may differentiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7f9c8b3951cadaed61bf6c72a2fedac2
https://pubmed.ncbi.nlm.nih.gov/10201938

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CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response

Autor: Wc, Gause, Sj, Chen, Rj, Greenwald, Mj, Halvorson, Lu P, Xd, Zhou, Sc, Morris, Kp, Lee, Ch, June, Fd, Finkelman, Joseph Urban, Abe R

Publikováno v: Europe PubMed Central

T cell differentiation to effector cell function is required for the development of a type 2 immune response. The T cell surface molecule, CD28, is widely considered to be the principal costimulatory molecule involved in T cell differentiation to eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1feb92171174fce4b835f732cf9d0772
https://pubmed.ncbi.nlm.nih.gov/9126966

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IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum

Autor: Joseph Urban, Fayer R, Sj, Chen, Wc, Gause, Mk, Gately, Fd, Finkelman

Publikováno v: Europe PubMed Central

The protozoan parasite Cryptosporidium parvum (Cp) causes diarrhea that can be acutely severe in immunocompetent persons and can become chronic and life-threatening in immunocompromised individuals. Because studies in mice have implicated IFN-gamma i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f230a373ec26939dda367637b205fcc1
https://pubmed.ncbi.nlm.nih.gov/8598471

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IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice

Autor: Joseph Urban, Cr, Maliszewski, Kb, Madden, Im, Katona, Fd, Finkelman

Publikováno v: Europe PubMed Central

We examined the ability of a long acting formulation of IL-4 (IL-4/anti-IL-4 mAb complexes) to limit established infections of normal and immune deficient mice with two nematode parasites: Heligmosomoides polygyrus and Nippostrongylus brasiliensis. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ff2139df06712faa23ff199165643203
https://pubmed.ncbi.nlm.nih.gov/7722320

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IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis

Autor: Joseph Urban, Kb, Madden, Aw, Cheever, Pp, Trotta, Im, Katona, Fd, Finkelman

Publikováno v: Europe PubMed Central

Mice infected with the gastrointestinal nematode parasite Nippostrongylus brasiliensis (Nb) develop responses associated with enhanced production of IL-4 (increased serum IgE levels and intestinal mucosal mastocytosis) and IL-5 (tissue and peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::df710e5c954cc76b2eb8451c8f4673be
https://pubmed.ncbi.nlm.nih.gov/8258713

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Purified Fc epsilon R+ bone marrow and splenic non-B, non-T cells are highly enriched in the capacity to produce IL-4 in response to immobilized IgE, IgG2a, or ionomycin

Autor: Ra, Seder, Plaut M, Barbieri S, Joseph Urban, Fd, Finkelman, We, Paul

Publikováno v: Europe PubMed Central

Non-B, non-T cells from spleen and bone marrow cells produce IL-4 in response to cross-linkage of high affinity receptors for Fc epsilon R or Fc gamma RII, and to treatment with calcium ionophores. Cells bearing high affinity Fc epsilon R constituted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b0a5829831f087cbad5bbb05894e7189
https://pubmed.ncbi.nlm.nih.gov/1830602

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Lack of Fc epsilon RII expression by murine B cells after in vivo immunization is directly associated with Ig secretion and not Ig isotype switching

Autor: Cm, Snapper, Jj, Hooley, Joseph Urban, Fd, Finkelman

Publikováno v: Europe PubMed Central

The "low affinity" Fc receptor for IgE (Fc epsilon RII) has been reported to be absent from normal murine and human B cells that express a membrane (m)Ig isotype other than mIgM or mIgD in vivo. This would suggest that Fc epsilon RII expression is sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a4d04224f39f7398bf2655abccffa86f
https://pubmed.ncbi.nlm.nih.gov/1826019

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The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis

Autor: Im, Katona, Joseph Urban, Fd, Finkelman

Publikováno v: Europe PubMed Central

The role of L3T4+ and Lyt-2+ T cells in protective immunity to Nippostrongylus brasiliensis (Nb) was studied in BALB/c mice that were depleted of either the L3T4+ or Lyt-2+ T cell population by injection with rat mAb specific for the appropriate dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::59716f2171d314cc81b5d94608f915ab
https://pubmed.ncbi.nlm.nih.gov/2966208

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T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production

Autor: Fd, Finkelman, Holmes J, Joseph Urban, We, Paul, Im, Katona

Publikováno v: Europe PubMed Central

To further define requirements for T cell help in the stimulation of an in vivo IgE response, we studied a system in which the injection of mice with a goat antibody to mouse IgD (GaMD) stimulates large polyclonal IgG1 and IgE responses. In this syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::04fbc74e6db7f6bed3c197b1504aa833
https://pubmed.ncbi.nlm.nih.gov/2521345

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