Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Fc-fusion proteins"'
Autor:
Elie Richel, Jannik T. Wagner, Stephan Klessing, Riccardo Di Vincenzo, Vladimir Temchura, Klaus Überla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundFc-fusion proteins have been successfully developed for therapeutic purposes, but are also a promising platform for the fast generation and purification of immunogens capable of inducing strong humoral immune responses in preclinical immuni
Externí odkaz:
https://doaj.org/article/fa5e0200210546b9819e91d6c35e2062
Autor:
Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytos
Externí odkaz:
https://doaj.org/article/3bac8310afe24019a754309f5e7597e8
Design and production of a novel chimeric human growth hormone superagonist fused to human Fc domain
Publikováno v:
Research in Pharmaceutical Sciences, Vol 17, Iss 3, Pp 284-293 (2022)
Background and purpose: Growth hormone (GH) has been known as a crucial metabolic hormone expressed at the pituitary and the other number of cells and tissues and responsible for body growth. Because of the short half-life of GH, daily subcutaneous i
Externí odkaz:
https://doaj.org/article/decab956de0a48dfafcec3eb7994269b
Autor:
Aatir A. Tungekar, Lloyd W. Ruddock
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14740 (2022)
Cost-effective production of therapeutic proteins in microbial hosts is an indispensable tool towards accessible healthcare. Many of these heterologously expressed proteins, including all antibody formats, require disulfide bond formation to attain t
Externí odkaz:
https://doaj.org/article/4a9392ed841c47d0ab5555b6b0db3df8
Autor:
Pia Gattinger, Shiva Izadi, Clemens Grünwald-Gruber, Somanath Kallolimath, Alexandra Castilho
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
The potential therapeutic value of many proteins is ultimately limited by their rapid in vivo clearance. One strategy to limit clearance by metabolism and excretion, and improving the stability of therapeutic proteins, is their fusion to the immunogl
Externí odkaz:
https://doaj.org/article/2c6572a51ae646ebbc0ea9e3afc1887d
Autor:
Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian
Publikováno v:
Molecules, Vol 27, Iss 17, p 5574 (2022)
Background: Targeting the CD47/SIRPα signaling pathway represents a novel approach to enhance anti-tumor immunity. However, the crystal structure of the CD47/SIRPα has not been fully studied. This study aims to analyze the structure interface of th
Externí odkaz:
https://doaj.org/article/cffe59263fa74969989d7397adb38f7b
Akademický článek
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Autor:
Ruddock, Aatir A. Tungekar, Lloyd W.
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14740
Cost-effective production of therapeutic proteins in microbial hosts is an indispensable tool towards accessible healthcare. Many of these heterologously expressed proteins, including all antibody formats, require disulfide bond formation to attain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c239fc42c0aca5b0ea35f15023f22e63
Akademický článek
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Akademický článek
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