Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Fc-engineering"'
Autor:
Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTThe development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. In addition to preventing viral infection through neutralization, Abs can clear infected cells and induce i
Externí odkaz:
https://doaj.org/article/41cb4663916447a9b561b48ff9e50a25
Autor:
Marjorie A. Shapiro
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Over 160 therapeutic and in vivo diagnostic monoclonal antibodies have been approved by the US FDA since the first monoclonal antibody, muromonab, was approved in 1986. Approximately 42% of these approvals were for the treatment or in vivo diagnosis
Externí odkaz:
https://doaj.org/article/c71c0f56cdc342cf9beb8fea1321b849
Autor:
Huiting Wu, Chang Liu, Qiang Yuan, Yan Qiao, Yongwei Ding, Lina Duan, Wenjing Li, Mengjia Zhang, Xuhua Zhang, Yanan Jiang, Jing Lu, Ziming Dong, Tao Wang, Kangdong Liu, Jimin Zhao
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTEsophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive tract with a low 5-year survival rate due to the lack of effective treatment methods. Although therapeutic monoclonal antibodies (mAbs) now play an impo
Externí odkaz:
https://doaj.org/article/11944828d30a4dccb33759dac6e0f864
Autor:
Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu, Gilad Kaplan
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTo combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2. In order to maximize the th
Externí odkaz:
https://doaj.org/article/9f5679dc1264437881b543ce3007dd81
Autor:
Firas Hamdan, Michaela Feodoroff, Salvatore Russo, Manlio Fusciello, Sara Feola, Jacopo Chiaro, Gabriella Antignani, Francesca Greco, Jeanette Leusen, Erkko Ylösmäki, Mikaela Grönholm, Vincenzo Cerullo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 264-276 (2023)
Immune checkpoint inhibitors have clinical success in prolonging the life of many cancer patients. However, only a minority of patients benefit from such therapy, calling for further improvements. Currently, most PD-L1 checkpoint inhibitors in the cl
Externí odkaz:
https://doaj.org/article/c101489aa59748e7965fdcfb82860f67
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2402 (2023)
Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions. Recent advances in the Fc en
Externí odkaz:
https://doaj.org/article/2145a615756647d4b6ad1de245f4a09e
Autor:
Yordkhwan W. Iwasaki, Kannan Tharakaraman, Vidya Subramanian, Amnart Khongmanee, Andrew Hatas, Eduardo Fleischer, Troy T. Rurak, Patchara Ngok-ngam, Phanthakarn Tit-oon, Mathuros Ruchirawat, Jutamaad Satayavivad, Mayuree Fuangthong, Ram Sasisekharan
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Bispecific antibodies (BsAbs) form an exciting class of bio-therapeutics owing to their multispecificity. Although numerous formats have been developed, generation of hetero-tetrameric IgG1-like BsAbs having acceptable safety and pharmacokinetics pro
Externí odkaz:
https://doaj.org/article/0b05f98023ee4509875b0b2c461a97c0
Autor:
Florian Heinkel, Meghan M. Verstraete, Siran Cao, Janessa Li, Patrick Farber, Elizabeth Stangle, Begonia Silva-Moreno, Fangni Peng, Surjit Dixit, Martin J. Boulanger, Thomas Spreter Von Kreudenstein, Eric Escobar-Cabrera
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Immunoglobulin G (IgG) has served as a traditional framework for antibody-based biology, and engineering approaches for creating multispecific therapeutics have greatly expanded its applicability. Despite these developments, there are limits to the f
Externí odkaz:
https://doaj.org/article/3ff0d51cf58546558f21c46d25e34435
Autor:
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen. This is because antigen degradation is reduced by the formation of antigen–antibo
Externí odkaz:
https://doaj.org/article/664a7d33da584019aead7576585d2286
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