Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Fc glycosylation"'
Autor:
Tomasz K. Baginski, Karthik Veeravalli, Rebekah McKenna, Christopher Williams, Katherine Wong, Christina Tsai, Daniel Hewitt, Karthik Mani, Michael W. Laird
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Escherichia coli (E. coli) is a promising host for production of recombinant proteins (including antibodies and antibody fragments) that don’t require complex post-translational modifications such as glycosylation. During manufa
Externí odkaz:
https://doaj.org/article/4bf0565975cc45ce9f5a2e9b90ff2c0d
Autor:
Thijs L. J. van Osch, Juulke Steuten, Jan Nouta, Carolien A. M. Koeleman, Arthur E. H. Bentlage, Sebastiaan Heidt, Arend Mulder, Jan Voorberg, S. Marieke van Ham, Manfred Wuhrer, Anja ten Brinke, Gestur Vidarsson
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of platelet transfusion and is predominantly caused by the presence of alloantibodies directed against class I human leukocyte antigens (HLA). Opsonization of d
Externí odkaz:
https://doaj.org/article/754df94de50f494c88b096ba4996ae54
Autor:
Daniel W. Woodall, Thomas M. Dillon, Kevin Kalenian, Rupa Padaki, Scott Kuhns, David J. Semin, Pavel V. Bondarenko
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Antibodies facilitate targeted cell killing by engaging with immune cells such as natural killer cells through weak binding interactions with Fcγ receptors on the cell surface. Here, we evaluate the binding affinity of the receptor FcγRIIIa V158 (C
Externí odkaz:
https://doaj.org/article/3d80519d7d5a4b369155036a9e5272d1
Akademický článek
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Autor:
Inbal Farkash, Tali Feferman, Noy Cohen-Saban, Yahel Avraham, David Morgenstern, Grace Mayuni, Natasha Barth, Yaniv Lustig, Liron Miller, Dror S. Shouval, Asaf Biber, Ilya Kirgner, Yishai Levin, Rony Dahan
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110114- (2021)
Summary: Messenger RNA-based vaccines against COVID-19 induce a robust anti-SARS-CoV-2 antibody response with potent viral neutralization activity. Antibody effector functions are determined by their constant region subclasses and by their glycosylat
Externí odkaz:
https://doaj.org/article/049b5eca979b4cdfa21bb6aa2b12feff
Autor:
Patricia S. Grace, Sepideh Dolatshahi, Lenette L. Lu, Adam Cain, Fabrizio Palmieri, Linda Petrone, Sarah M. Fortune, Tom H. M. Ottenhoff, Douglas A. Lauffenburger, Delia Goletti, Simone A. Joosten, Galit Alter
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
With an estimated 25% of the global population infected with Mycobacterium tuberculosis (Mtb), tuberculosis (TB) remains a leading cause of death by infectious diseases. Humoral immunity following TB treatment is largely uncharacterized, and antibody
Externí odkaz:
https://doaj.org/article/fa7779f79cd742d18b14d6b5209ea8be
Autor:
Steffen Lippold, Simone Nicolardi, Elena Domínguez-Vega, Anna-Katharina Heidenreich, Gestur Vidarsson, Dietmar Reusch, Markus Haberger, Manfred Wuhrer, David Falck
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1191-1196 (2019)
Determination of the impact of individual antibody glycoforms on FcɣRIIIa affinity, and consequently antibody-dependent cell-mediated cytotoxicity (ADCC) previously required high purity glycoengineering. We hyphenated FcɣRIIIa affinity chromatograp
Externí odkaz:
https://doaj.org/article/29cf8fc232b146ef88ded0217ad4cb13
Autor:
Liu, Chiu-Ping, Tsai, Tsung-I., Cheng, Ting, Shivatare, Vidya S., Wu, Chung-Yi, Wu, Chung-Yi, Wong, Chi-Huey
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Jan . 115(4), 720-725.
Externí odkaz:
https://www.jstor.org/stable/26506460
Autor:
Steffen Lippold, Alexander Knaupp, Arnoud H. de Ru, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Erwin van Puijenbroek, Steven W. de Taeye, Dietmar Reusch, Gestur Vidarsson, Manfred Wuhrer, Tilman Schlothauer, David Falck
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The crystallizable fragment (Fc) of immunoglobulin G (IgG) activates key immunological responses by interacting with Fc gamma receptors (FcɣR). FcɣRIIIb contributes to neutrophil activation and is involved in antibody-dependent cellular cytotoxicit
Externí odkaz:
https://doaj.org/article/304e5e39a8ea4ca9a3464086e8534f7a
Autor:
M. Muenchhoff, A. W. Chung, J. Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kløverpris, Alasdair Leslie, Thumbi Ndung’u, Penny Moore, Galit Alter, Philip J. R. Goulder
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying
Externí odkaz:
https://doaj.org/article/f66d862dd1194fa4867e6134d3109279