Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Fc effector function"'
Autor:
Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTThe development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. In addition to preventing viral infection through neutralization, Abs can clear infected cells and induce i
Externí odkaz:
https://doaj.org/article/41cb4663916447a9b561b48ff9e50a25
Autor:
Chuang Li, Jie Yu, Rahma Issa, Lili Wang, Mingzhe Ning, Shengxia Yin, Jie Li, Chao Wu, Yuxin Chen
Publikováno v:
Emerging Microbes and Infections (2024)
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants raise concerns about decreased vaccine efficacy, vaccines continue to confer robust protection in humans, implying that immunity beyond neutralization contributes to vacci
Externí odkaz:
https://doaj.org/article/23c8fab6d6934e8890958f62478538de
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTAntibodies represent the primary correlate of immunity following most clinically approved vaccines. However, their mechanisms of action vary from pathogen to pathogen, ranging from neutralization, to opsonophagocytosis, to cytotoxicity. Antib
Externí odkaz:
https://doaj.org/article/cd6463637e2243e0bf2bcc3ada66b285
Autor:
Lili Wang, Chuang Li, Wanting Li, Liwei Zhao, Tiantian Zhao, Lin Chen, Ming Li, Jing Fan, Jiayan Li, Chao Wu, Yuxin Chen
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Although humoral responses elicited by infection or vaccine lost the ability to prevent transmission against Omicron, vaccine-induced antibodies may still contribute to disease attenuation through Fc-mediated effector functions. However, Fc effector
Externí odkaz:
https://doaj.org/article/f67231f1a32248fbbe586d8771d1c59c
Akademický článek
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Autor:
William D. Tolbert, Neelakshi Gohain, Paul G. Kremer, Andrew P. Hederman, Dung N. Nguyen, Verna Van, Rebekah Sherburn, George K. Lewis, Andrés Finzi, Justin Pollara, Margaret E. Ackerman, Adam W. Barb, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fc mediated effector functions of antibodies play important roles in immunotherapies and vaccine efficacy but assessing those functions in animal models can be challenging due to species differences. Rhesus macaques, Macaca mulatta (Mm) share approxi
Externí odkaz:
https://doaj.org/article/35ba42702de84fb390327cdf58ef34a5
Autor:
Stephen M. Carpenter, Lenette L. Lu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite over a century of research, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), continues to kill 1.5 million people annually. Though less than 10% of infected individuals develop active disease, the specific host immu
Externí odkaz:
https://doaj.org/article/7912d217524143a780f782bee10d2f6e
Autor:
Carolyn M. Boudreau, John S. Burke, IV, Kiel D. Shuey, Caitlin Wolf, Joanne Katz, James Tielsch, Subarna Khatry, Steven C. LeClerq, Janet A. Englund, Helen Y. Chu, Galit Alter
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110337- (2022)
Summary: Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vacci
Externí odkaz:
https://doaj.org/article/8604ce5d6f5d4d78a48f0c88247b72c9
Autor:
Xin Chen, Liu Xue, Xiao Ding, Jing Zhang, Lei Jiang, Sha Liu, Hongjia Hou, Bin Jiang, Liang Cheng, Qing Zhu, Lijie Zhang, Xiaosui Zhou, Jie Ma, Qi Liu, Yucheng Li, Zhiying Ren, Beibei Jiang, Xiaomin Song, Jing Song, Wei Jin, Min Wei, Zhirong Shen, Xuesong Liu, Lai Wang, Kang Li, Tong Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
TIGIT (T-cell immunoglobulin and ITIM domain) has emerged as a promising target in cancer immunotherapy. It is an immune “checkpoint” inhibitor primarily expressed on activated T cells, NK cells and Tregs. Engagement of TIGIT to its ligands PVR a
Externí odkaz:
https://doaj.org/article/efb44fe75f834184b193439f28167d86
Autor:
William D. Tolbert, Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, Valerie Bekker, Sarah V. Mudrak, Anthony L. DeVico, George K. Lewis, James F. Theis, Abraham Pinter, M. Anthony Moody, David Easterhoff, Kevin Wiehe, Justin Pollara, Kevin O. Saunders, Georgia D. Tomaras, Margaret Ackerman, Guido Ferrari, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Passive transfer of monoclonal antibodies (mAbs) of human origin into Non-Human Primates (NHPs), especially those which function predominantly by a Fc-effector mechanism, requires an a priori preparation step, in which the human mAb is reengineered t
Externí odkaz:
https://doaj.org/article/ebe45cad4e6d401b8cdeec5671af1e07