Zobrazeno 1 - 10
of 9 484
pro vyhledávání: '"Fc Receptor"'
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Generalized myasthenia gravis (gMG) can be managed with acetylcholinesterase inhibitors (AChEis; e.g., pyridostigmine), corticosteroids, other immunosuppressive drugs (e.g., tacrolimus), and their combinations. Intravenous immunog
Externí odkaz:
https://doaj.org/article/215a37aa495e4c0187f2b758a7de23f8
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Immuno-oncological cancer management is shifting to neoadjuvant treatments. In patients with gastrointestinal cancers, particularly locally advanced rectal cancer, neoadjuvant chemoimmunotherapy often induce complete responses, hence avoiding surgica
Externí odkaz:
https://doaj.org/article/18ec85d9401b497a93c1b96895318086
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
A critical attribute of therapeutic antibodies is their ability to engage with humoral or cellular effector mechanisms, and this depends on the ability of the Fc region to bind to complement (C1q) or Fc receptors. Investigators have sought to optimiz
Externí odkaz:
https://doaj.org/article/510b104248724183bfa4bd7e26ced614
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been used in the clinic, but
Externí odkaz:
https://doaj.org/article/62ff2163c22f4831b54f543b2073ecdf
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as th
Externí odkaz:
https://doaj.org/article/e26e8d4cee664eda81a36e31dae1d509
Autor:
Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodi
Externí odkaz:
https://doaj.org/article/5722afa10f5c4409a38943daca3eb2a0
Autor:
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Rozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequently us
Externí odkaz:
https://doaj.org/article/f74b0a47f067425f9e3ed7abc893041a
Efgartigimod treatment for generalized myasthenia gravis: a single-center case series of 16 patients
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundEfgartigimod was approved in Japan in January 2022 for the treatment of generalized myasthenia gravis (gMG), regardless of antibody status. This case series describes a real-world experience in Japan of efgartigimod treatment for gMG patien
Externí odkaz:
https://doaj.org/article/776a7f1e75ef4f8eaa038e76c93a1c2e
Autor:
Anna Zakrzewicz, Katrien Vanderheyden, Yad Galaly, Simon Feldhoff, Magdalena Sips, Maximilian Brinkhaus, Ritva Tikkanen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibo
Externí odkaz:
https://doaj.org/article/d8db3bf2f6a64a55929016d2d491384e
Autor:
Qianqian Zhang, Wenping Yang, Yun Qian, Yu Zhang, Huihui Zhao, Mingzhu Shu, Qingyang Li, Yanan Li, Yu Ding, Shiyu Shi, Yaxi Liu, Xi Cheng, Qi Niu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAutoimmune encephalitis (AE) comprises a group of inflammatory brain disorders mediated by autoimmune responses. Anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis, anti–leucine-rich glioma-inactivated 1 (LGI1) encephalitis, and
Externí odkaz:
https://doaj.org/article/eb33e227de1e4e28972b8d0e3ea1f25a