Reviving lost binding sites: Exploring calcium‐binding site transitions between human and murine CD23

Autor: Veronica F. Ilkow, Anna M. Davies, Balvinder Dhaliwal, Andrew J. Beavil, Brian J. Sutton, James M. McDonnell

Publikováno v: FEBS Open Bio, Vol 11, Iss 7, Pp 1827-1840 (2021)

Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses. IgE’s interaction with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor, unrelated to re

Externí odkaz: https://doaj.org/article/5fcdc2e1fa9d4377b70934cd23407cfe

Endothelial integrity may be regulated by a specific antigen via an IgE-mediated mechanism

Autor: Karolina Antosik, Maciej Borowiec, Marlena Broncel, Emilia Luczak, Paulina Gorzelak-Pabis, Katarzyna Wojdan, Maciej Chałubiński

Publikováno v: Postępy Higieny i Medycyny Doświadczalnej, Vol 71, Iss 1, Pp 162-169 (2017)

Background: Human vascular endothelial function and integrity may be regulated by many non-specific factors. However, the potential influence of specific antigens via an IgE-mediated mechanism remains unknown. The aim of the study was to determine th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999a9d6cbf53e26ea5f5582b6958eda
http://phmd.pl/gicid/pdf/01.3001.0010.3800

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High affinity targeting of CD23 inhibits IgE synthesis in human B cells

Autor: Fabian Zellweger, Patrick Buschor, Monique Vogel, Silvan Röthlisberger, Marc Fellmann

Publikováno v: Immunity, Inflammation and Disease
Fellmann, Marc; Buschor, Patrick; Röthlisberger, Silvan; Zellweger, Fabian; Vogel, Monique (2015). High affinity targeting of CD23 inhibits IgE synthesis in human B cells. Immunity, inflammation and disease, 3(4), pp. 339-349. Wiley 10.1002/iid3.72

The low‐affinity IgE receptor FcϵRII (CD23) is part of the regulatory system controlling IgE synthesis in human B cells and exists in membrane and soluble forms. Binding of IgE to CD23 has been described to have stabilizing effects and to prevent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131c0b9954a9385126d1498dcee2c0aa
http://europepmc.org/articles/PMC4693728

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