Zobrazeno 1 - 10
of 563
pro vyhledávání: '"Fcγ receptor"'
Autor:
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTRozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequ
Externí odkaz:
https://doaj.org/article/f74b0a47f067425f9e3ed7abc893041a
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Background Autoimmune hepatitis (AIH) is a T-cell-mediated autoimmune liver disease that can lead to liver injury and has a poor long-term prognosis. Mesenchymal stromal cells (MSCs) have immunosuppressive effects and can treat AIH. CD4+ T c
Externí odkaz:
https://doaj.org/article/3a4a19fdb91f4c83a1f0eb2b06b70582
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Tyro3, Axl, and Mertk (abbreviated TAMs) comprise a family of homologous type 1 receptor tyrosine kinases (RTKs) that have been implicated as inhibitory receptors that dampen inflammation, but their roles in the pathogenesis of rheumatoid ar
Externí odkaz:
https://doaj.org/article/e1451aac782943b4af7c6af8f987b7a1
Autor:
Wen Zhu, Yang Wang, Liangyin Lv, Hui Wang, Wenqiang Shi, Zexin Liu, Mingzhe Zhou, Jianwei Zhu, Huili Lu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2071-2085 (2023)
Developing universal CARs with improved flexible targeting and controllable activities is urgently needed. While several studies have suggested the potential of CD16a in tandem with monoclonal antibodies to construct universal CAR-T cells, the weak a
Externí odkaz:
https://doaj.org/article/483d45883d214370b509b2c31a785f89
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV−2) causes coronavirus disease 2019 (COVID−19). Antibodies induced by SARS-CoV−2 infection or vaccination play pivotal roles in the body’s defense against the virus; many monocl
Externí odkaz:
https://doaj.org/article/c8f4f26f466941008a03624ac128fe83
Autor:
Masanao Kyuuma, Ayaka Kaku, Chiemi Mishima-Tsumagari, Bunichiro Ogawa, Mayumi Endo, Yunoshin Tamura, Kei-ichiro Ishikura, Masashi Mima, Yutaka Nakanishi, Yasuyuki Fujii
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Biologics have become an important component of treatment strategies for a variety of diseases, but the immunogenicity of large immune complexes (ICs) and aggregates of biologics may increase risk of adverse events is a concern for biologics and it r
Externí odkaz:
https://doaj.org/article/93e7dbb80a1a452d968da965f61623be
Autor:
Mansoor Karimifar, Khosro Akbari, Reza ArefNezhad, Farshid Fathi, Mohammad Moosaeepour, Hossein Motedayyen
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors in susceptibility to SLE. Th
Externí odkaz:
https://doaj.org/article/f71a3249350a488596a72285bcc6decf
Autor:
Marie-Luise Arnold, Ulrike Steffen, Michael Wiesener, Christian Bach, Bernd M. Spriewald, Monika Lindemann
Publikováno v:
Immuno, Vol 2, Iss 2, Pp 372-386 (2022)
Immunoglobulin A (IgA) is the most abundant antibody isotype in humans and anti-HLA IgA was found in sera of transplant recipients. Focusing on patients awaiting kidney re-transplantation, we tested the impact of anti-HLA-class I/II IgA antibodies on
Externí odkaz:
https://doaj.org/article/03e2fbf3ea174ccc804d9031a9cd7403
Publikováno v:
Antibodies, Vol 12, Iss 3, p 54 (2023)
Therapeutic antibodies represent the most significant modality in biologics, with around 150 approved drugs on the market. In addition to specific target binding mediated by the variable fragments (Fvs) of the heavy and light chains, antibodies posse
Externí odkaz:
https://doaj.org/article/88e7dc5c418f4819ba70208472531bf6
Autor:
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng, Juan Zhang, Yongmei Chen, Haochu Huang, Wyne P. Lee, Yan Wu, Minhong Yan
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB). Here, we descri
Externí odkaz:
https://doaj.org/article/a4637a431cdc4e5c801dd6e32b9072f3