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Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1

Autor: Bissonnette M, Khare S, Fc, Lintig, Rk, Wali, Nguyen L, Zhang Y, Hart J, Skarosi S, Varki N, Gerry Boss, Ta, Brasitus

Publikováno v: Europe PubMed Central

Azoxymethane (AOM)-induced colonic carcinogenesis involves a number of mutations, including those in the K-ras gene and CTNNB1, that codes for beta-catenin. Prior in vitro studies have also demonstrated that wild type p21(K-ras) can be activated by e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad07aab994e8a35ac6a8658834bce596
http://europepmc.org/abstract/med/10969813

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