Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion

Autor: Marshall Hogarth, Fc, Garton, Pj, Houweling, Tukiainen T, Lek M, Dg, Macarthur, Jt, Seto, Kg, Quinlan, Yang N, Si, Head, Kn, North

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6e0c119f8331cd9c251155341d6413fd
http://europepmc.org/abstract/med/26681802

Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia.

Autor: Restuadi R; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Garton FC; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Benyamin B; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, SA, Australia., Lin T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Williams KL; Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Vinkhuyzen A; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., van Rheenen W; UMC Utrecht Brain Center Rudolf Magnus, Utrecht, Netherlands., Zhu Z; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Laing NG; Centre for Medical Research, University of Western Australia, Nedlands, WA, Australia.; Harry Perkins Institute of Medical Research, Nedlands, WA, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia Institute, Randwick, NSW, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, The Prince of Wales Hospital, UNSW, Randwick, NSW, Australia., Ngo ST; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Steyn FJ; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia., Wallace L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Henders AK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Needham M; Fiona Stanley Hospital, Perth, WA, Australia.; Notre Dame University, Fremantle, WA, Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, VIC, Australia., Nicholson G; Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.; ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, NSW, Australia., Rowe DB; Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Henderson RD; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., McCombe PA; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia., Blair IP; Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., McRae AF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. a.mcrae@uq.edu.au.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2022 May; Vol. 30 (5), pp. 532-539. Date of Electronic Publication: 2021 Apr 27.

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.

Autor: van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. w.vanrheenen-2@umcutrecht.nl., van der Spek RAA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bakker MK; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hop PJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Klein N; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Westra HJ; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Bakker OB; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Deelen P; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Shireby G; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Hannon E; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Moisse M; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., Baird D; Translational Biology, Biogen, Boston, MA, USA.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK., Restuadi R; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Dolzhenko E; Illumina, San Diego, CA, USA., Dekker AM; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Gawor K; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Westeneng HJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Tazelaar GHP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Eijk KR; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kooyman M; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Byrne RP; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doherty M; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Heverin M; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Al Khleifat A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Iacoangeli A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK., Shatunov A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ticozzi N; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Smith BN; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gromicho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Chandran S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Pal S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Morrison KE; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK., Orrell RW; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Sendtner M; Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany., Meyer T; Charité University Hospital, Humboldt University, Berlin, Germany., Başak N; Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey., van der Kooi AJ; Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands., Ratti A; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy., Fogh I; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy., Lauria G; 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', MIlan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Corti S; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy.; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Cereda C; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., Sproviero D; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., D'Alfonso S; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy., Sorarù G; Department of Neurosciences, University of Padova, Padova, Italy., Siciliano G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Filosto M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Padovani A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Brunetti M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Canosa A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Grassano M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Beghi E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Pupillo E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Logroscino G; Department of Clinical Research in Neurology, University of Bari at 'Pia Fondazione Card G. Panico' Hospital, Bari, Italy., Nefussy B; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Osmanovic A; Department of Neurology, Hannover Medical School, Hannover, Germany.; Essener Zentrum für Seltene Erkrankungen (EZSE), University Hospital Essen, Essen, Germany., Nordin A; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Lerner Y; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Zabari M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Gotkine M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Baloh RH; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bell S; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Vourc'h P; Service de Biochimie et Biologie Moléculaire, CHU de Tours, Tours, France.; UMR 1253, Université de Tours, Inserm, Tours, France., Corcia P; UMR 1253, Université de Tours, Inserm, Tours, France.; Centre de référence sur la SLA, CHU de Tours, Tours, France., Couratier P; Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.; UMR 1094, Université de Limoges, Inserm, Limoges, France., Millecamps S; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France., Meininger V; Hôpital des Peupliers, Ramsay Générale de Santé, Paris, France., Salachas F; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.; Département de Neurologie, Centre de référence SLA Ile de France, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Mora Pardina JS; ALS Unit, Hospital San Rafael, Madrid, Spain., Assialioui A; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Rojas-García R; MND Clinic, Neurology Department, Hospital de la Santa Creu i Sant Pau de Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain., Dion PA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Ross JP; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany., Weishaupt JH; Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Brenner D; Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Freischmidt A; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany., Bensimon G; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France.; Pharmacologie Sorbonne Université, Paris, France.; Institut du Cerveau, Paris Brain Institute ICM, Paris, France.; Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France., Brice A; Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France., Durr A; Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France., Payan CAM; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France., Saker-Delye S; Genethon, CNRS UMR, Evry, France., Wood NW; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, UK., Topp S; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Rademakers R; Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Tittmann L; Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany., Lieb W; Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Braun A; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Kraft J; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Whiteman DC; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Olsen CM; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Uitterlinden AG; Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Hofman A; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Rietschel M; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.; Central Institute of Mental Health, Mannheim, Germany., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany.; Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Juelich, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany., Amouyel P; INSERM UMR1167-RID-AGE LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, Centre Hospitalier of the University of Lille, Institut Pasteur de Lille, Lille, France., Traynor BJ; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA., Mitne Neto M; Universidade de São Paulo, São Paulo, Brazil., Cauchi RJ; Centre for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta., Ophoff RA; University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Wiedau-Pazos M; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Lomen-Hoerth C; Department of Neurology, University of California, San Francisco, CA, USA., van Deerlin VM; Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Grosskreutz J; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.; Precision Neurology Unit, Department of Neurology, University Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany., Roediger A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Gaur N; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Jörk A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Barthel T; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Theele E; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Ilse B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Stubendorff B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Witte OW; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Steinbach R; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Hübner CA; Institute of Human Genetics, Jena University Hospital, Jena, Germany., Graff C; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Brylev L; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Fominykh V; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Demeshonok V; ALS-Care Center, 'GAOORDI', Medical Clinic of the St. Petersburg, St. Petersburg, Russia., Ataulina A; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia., Rogelj B; Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.; Biomedical Research Institute BRIS, Ljubljana, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Koritnik B; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Zidar J; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Ravnik-Glavač M; Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Glavač D; Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Stević Z; Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia., Drory V; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Povedano M; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Blair IP; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Benyamin B; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Australian Centre for Precision Health and Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia., Henderson RD; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Furlong S; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, Victoria, Australia., McCombe PA; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Needham M; Fiona Stanley Hospital, Perth, Western Australia, Australia.; Notre Dame University, Fremantle, Western Australia, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Ngo ST; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Nicholson GA; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.; Northcott Neuroscience Laboratory, ANZAC Research Institute, Concord, New South Wales, Australia.; Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Steyn FJ; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; The School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Williams KL; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia Institute, Randwick, New South Wales, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, the Prince of Wales Hospital, UNSW, Randwick, New South Wales, Australia., Henders AK; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Wallace L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Pinto S; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Petri S; Department of Neurology, Hannover Medical School, Hannover, Germany., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Silani V; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Curtis CJ; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Breen G; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA, USA., Brown RH Jr; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Shaw CE; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Andersen PM; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Groen EJN; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Es MA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fan D; Department of Neurology, Third Hospital, Peking University, Beijing, China., Garton FC; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Eberle MA; Illumina, San Diego, CA, USA., Mill J; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., McLaughlin RL; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Kenna KP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Tsai E; Translational Biology, Biogen, Boston, MA, USA., Runz H; Translational Biology, Biogen, Boston, MA, USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; King's College Hospital, London, UK., Van Damme P; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.veldink@umcutrecht.nl.

Publikováno v: Nature genetics [Nat Genet] 2022 Mar; Vol. 54 (3), pp. 361.

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.

Autor: Restuadi R; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Steyn FJ; School of Biomedical Sciences, The University of Queensland, QLD, Brisbane, 4072, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, QLD, Brisbane, 4029, Australia.; Centre for Clinical Research, The University of Queensland, QLD, Brisbane, 4019, Australia., Kabashi E; Imagine Institute, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1163, Paris Descartes Université, 75015, Paris, France.; Sorbonne Université, Université Pierre et Marie Curie (UPMC), Université de Paris 06, INSERM Unité 1127, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225, Institut du Cerveau et de la Moelle Épinière (ICM), 75013, Paris, France., Ngo ST; Centre for Clinical Research, The University of Queensland, QLD, Brisbane, 4019, Australia.; Queensland Brain Institute, The University of Queensland, QLD, Brisbane, 4072, Australia.; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD, Brisbane, 4072, Australia., Cheng FF; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Nabais MF; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia.; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Thompson MJ; Department of Computer Science, University of California Los Angeles, Los Angeles, CA, USA.; Department of Bioinformatics, University of California Los Angeles, Los Angeles, CA, USA., Qi T; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Wu Y; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Henders AK; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Wallace L; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Bye CR; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3052, Australia., Turner BJ; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3052, Australia., Ziser L; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, VIC, 3195, Australia., McCombe PA; Department of Neurology, Royal Brisbane and Women's Hospital, QLD, Brisbane, 4029, Australia.; Centre for Clinical Research, The University of Queensland, QLD, Brisbane, 4019, Australia., Needham M; Fiona Stanley Hospital, Perth, WA, 6150, Australia.; Notre Dame University, Fremantle, WA, 6160, Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, 6150, Australia., Schultz D; Department of Neurology, Flinders Medical Centre, Bedford Park, SA, 5042, Australia., Kiernan MC; Brain & Mind Centre, University of Sydney, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, NSW, 2006, Australia., van Rheenen W; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van den Berg LH; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Veldink JH; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Ophoff R; Department of Computer Science, University of California Los Angeles, Los Angeles, CA, USA.; Department of Bioinformatics, University of California Los Angeles, Los Angeles, CA, USA., Gusev A; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA., Zaitlen N; Department of Computer Science, University of California Los Angeles, Los Angeles, CA, USA.; Department of Bioinformatics, University of California Los Angeles, Los Angeles, CA, USA.; Department of Neurology, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, 94158, USA., McRae AF; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia., Henderson RD; Department of Neurology, Royal Brisbane and Women's Hospital, QLD, Brisbane, 4029, Australia.; Centre for Clinical Research, The University of Queensland, QLD, Brisbane, 4019, Australia.; Queensland Brain Institute, The University of Queensland, QLD, Brisbane, 4072, Australia., Wray NR; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia.; Queensland Brain Institute, The University of Queensland, QLD, Brisbane, 4072, Australia., Giacomotto J; Queensland Brain Institute, The University of Queensland, QLD, Brisbane, 4072, Australia.; Queensland Centre for Mental Health Research, West Moreton Hospital and Health Service, Wacol, QLD, 4076, Australia., Garton FC; Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, 4072, Australia. f.garton@uq.edu.au.

Publikováno v: Genome medicine [Genome Med] 2022 Jan 19; Vol. 14 (1), pp. 7. Date of Electronic Publication: 2022 Jan 19.

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.

Autor: Nabais MF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Laws SM; School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA, 6027, Australia., Lin T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Vallerga CL; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; Department of Internal Medicine, Erasmus MC, University Medical Center, 3015GD, Rotterdam, The Netherlands., Armstrong NJ; Murdoch University, 90 South St, Murdoch, WA, 6150, Australia., Blair IP; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, SA, 5001, Australia., Kwok JB; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia.; Neuroscience Research Australia Institute, Randwick, NSW, 2031, Australia., Mellick GD; Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia.; Neuropsychiatric Institute, The Prince of Wales Hospital, UNSW, Randwick, NSW, 2031, Australia., Wallace L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Henders AK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Zwamborn RAJ; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Hop PJ; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Lunnon K; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Pishva E; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Roubroeks JAY; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland., Tsolaki M; 1st Department of Neurology, Memory and Dementia Unit, Aristotle University of Thessaloniki, Thessaloniki, Greece., Mecocci P; Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy., Lovestone S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK., Kłoszewska I; Medical University of Lodz, Lodz, Poland., Vellas B; INSERM U 558, University of Toulouse, Toulouse, France., Furlong S; Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia., Garton FC; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Henderson RD; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, VIC, 3195, Australia., McCombe PA; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia., Needham M; Fiona Stanley Hospital, Perth, WA, 6150, Australia.; Notre Dame University, Fremantle, WA, 6160, Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, 6150, Australia., Ngo ST; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia., Nicholson G; ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, NSW, 2139, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia., Steyn FJ; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia., Williams KL; Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia., Anderson TJ; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand., Bentley SR; Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia., Dalrymple-Alford J; New Zealand Brain Research Institute, Christchurch, New Zealand.; School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand., Fowder J; Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia., Gratten J; Mater Research, Translational Research Institute, Brisbane, Australia.; Mater Research Institute, The University of Queensland, Brisbane, Australia., Halliday G; Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Hickie IB; Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Kennedy M; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand., Lewis SJG; Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Montgomery GW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Pearson J; Department of Pathology, University of Otago, Christchurch, New Zealand., Pitcher TL; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand., Silburn P; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia., Zhang F; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Harris SE; Department of Psychology, Lothian Birth Cohorts group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Deary IJ; Department of Psychology, Lothian Birth Cohorts group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Jones AR; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., Shatunov A; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., Iacoangeli A; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., van Rheenen W; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van den Berg LH; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Shaw PJ; SITraN, University of Sheffield, Sheffield, UK., Shaw CE; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., Morrison KE; Queen's University Belfast, Belfast, Northern Ireland, UK., Al-Chalabi A; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK.; King's College Hospital, London, SE5 9RS, UK., Veldink JH; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Hannon E; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Mill J; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK., Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia., McRae AF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. a.mcrae@uq.edu.au.

Publikováno v: Genome biology [Genome Biol] 2021 Mar 26; Vol. 22 (1), pp. 90. Date of Electronic Publication: 2021 Mar 26.