Zobrazeno 1 - 10
of 738
pro vyhledávání: '"Fazlul H Sarkar"'
Publikováno v:
F1000Research, Vol 2 (2013)
“Let food be thy medicine and medicine be thy food” was quoted by Hippocrates more than two thousand years ago and since ancient times the health benefits of different natural agents have been exploited. In modern research, the disease preventive
Externí odkaz:
https://doaj.org/article/9e06ad470e9b406f823f718ace532726
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Lung cancer is the most common cancer in the world. Despite modern advancements in surgeries, chemotherapies and radiotherapies over the past few years, lung cancer still remains a very difficult disease to treat. This has left the death rate from lu
Externí odkaz:
https://doaj.org/article/30cd2d52be9543b2a0f615b782ceed58
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68543 (2013)
Despite recent advancement in medicine, nearly 50% of patients with colorectal cancer show recurrence of the disease. Although the reasons for the high relapse are not fully understood, the presence of chemo- and radiotherapy-resistant cancer stem/st
Externí odkaz:
https://doaj.org/article/57b622ad80d34d12862f207971b29ba3
Autor:
Jia Ma, Qing Zhang, Sulian Chen, Binbin Fang, Qingling Yang, Changjie Chen, Lucio Miele, Fazlul H Sarkar, Jun Xia, Zhiwei Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69485 (2013)
Although mitochondrial dysfunction has been observed in various types of human cancer cells, the molecular mechanism underlying mitochondrial dysfunction mediated tumorigenesis remains largely elusive. To further explore the function of mitochondria
Externí odkaz:
https://doaj.org/article/38d311fedd0844a5835cd50c7b6cfc25
Autor:
Yong-Chao Ma, Chong Shi, Yao-Nan Zhang, Lan-Ge Wang, Hao Liu, Hong-Ti Jia, Yu-Xiang Zhang, Fazlul H Sarkar, Ze-Sheng Wang
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33414 (2012)
The proteolytic activity of Furin responsible for processing full length Notch-1 (p300) plays a critical role in Notch signaling. The amplitude and duration of Notch activity can be regulated at various points in the pathway, but there has been no re
Externí odkaz:
https://doaj.org/article/79b7d107ad9c42088be5b5b94bd99cae
Autor:
Dejuan Kong, Elisabeth Heath, Wei Chen, Michael L Cher, Isaac Powell, Lance Heilbrun, Yiwei Li, Shadan Ali, Seema Sethi, Oudai Hassan, Clara Hwang, Nilesh Gupta, Dhananjay Chitale, Wael A Sakr, Mani Menon, Fazlul H Sarkar
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33729 (2012)
The emergence of castrate-resistant prostate cancer (CRPC) contributes to the high mortality of patients diagnosed with prostate cancer (PCa), which in part could be attributed to the existence and the emergence of cancer stem cells (CSCs). Recent st
Externí odkaz:
https://doaj.org/article/17f9ce19333f4798b26b776ee9ac1ea3
Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells.
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45045 (2012)
Clinical experience of histone deacetylase inhibitors (HDACIs) in patients with solid tumors has been disappointing; however, the molecular mechanism of treatment failure is not known. Therefore, we sought to investigate the molecular mechanism of tr
Externí odkaz:
https://doaj.org/article/76f22f534fb04bad9d3063b2dbde3b92
Autor:
Archana Thakur, Lawrence G Lum, Dana Schalk, Asfar Azmi, Sanjeev Banerjee, Fazlul H Sarkar, Ramzi Mohommad
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47520 (2012)
Pancreatic cancer is a deadly disease and has the worst prognosis among almost all cancers and is in dire need of new and improved therapeutic strategies. Conditioning of tumor cells with chemotherapeutic drug has been shown to enhance the anti-tumor
Externí odkaz:
https://doaj.org/article/919941e790f4455c8e6f65f711faf123
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33011 (2012)
Prostate cancer (PCa) bone metastases have long been believed to be osteoblastic because of bone remodeling leading to the formation of new bone. However, recent studies have shown increased osteolytic activity in the beginning stages of PCa bone met
Externí odkaz:
https://doaj.org/article/7c490c144af140b8820aef86ab979aca
Autor:
Bin Bao, Shadan Ali, Aamir Ahmad, Asfar S Azmi, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Seema Sethi, Amro Aboukameel, Subhash B Padhye, Fazlul H Sarkar
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50165 (2012)
Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been shown to be associated with therapeutic resistance, and contributes to
Externí odkaz:
https://doaj.org/article/0ce2703260894615a1dfa33228380763