South Asian medical cohorts reveal strong founder effects and high rates of homozygosity

Autor: Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Radha Venkatesan, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, Jacqueline Robinson, Ruchi Chaudhary, Sakthivel Murugan, Zameer ul-Asar, Imran Saleem, Unzila Ishtiaq, Areej Fatima, Saqib Shafi Sheikh, Shahid Hameed, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Santosh Gopi Krishna Gadde, Priya B V, Naveen Kumar Naik, Minxian Wang, Pui-Yan Kwok, Amit V. Khera, B. R. Lakshmi, Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele di Angelantonio, Aliya Naheed, Vinay Goyal, Rukmini M. Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M. Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Atanu Biswas, Pramod Kumar Pal, Uday B. Muthane, Shymal K. Das, Vedam L. Ramprasad, Prashanth L. Kukkle, Somasekar Seshagiri, Sekar Kathiresan, Arkasubhra Ghosh, V. Mohan, Danish Saleheen, Eric W. Stawiski, Andrew S. Peterson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored people from some parts of the world, such as South Asia. Here we describe whole g

Externí odkaz: https://doaj.org/article/c5c553736d824d84a9c6fd8682dcf4dd

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.

Autor: Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen

Publikováno v: PLoS Genetics, Vol 18, Iss 4, p e1010093 (2022)

Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous stu

Externí odkaz: https://doaj.org/article/9c0268137d414840bbba8d1073dcccdf

Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

Autor: Zoubia Hina, Julian L. Griffin, Asif Rasheed, Nadeem Qamar, Danish Saleheen, Dirk S. Paul, Imran Saleem, Taniya Sattar, M. Ishaq, Nadeem Hayat Mallick, Adam S. Butterworth, Philippe M. Frossard, Daniel Ziemek, Fazal-ur-Rehman Memon, Syed Nadeem Hasan Rizvi, Albert Koulman, Anjum Jalal, Tahir Saghir, John Danesh, Angela M. Wood, David Stacey, Eric B. Fauman, Unzila Ishtiaq, Anis Memon, Rachel M. Y. Ong, Eric L. Harshfield, Shahid Abbas, Zameer-ul-Asar, Zia Yaqub, Syed Zahed Rasheed

Publikováno v: BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
BMC Medicine

Background Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13be67ecd921d8853d5f11b83360977
https://www.repository.cam.ac.uk/handle/1810/327542

Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease loci

Autor: Unzila Ishtiaq, Dirk S. Paul, Zoubia Hina, Philippe M. Frossard, Danish Saleheen, Eric B. Fauman, Syed Nadeem Hasan Rizvi, Rachel M. Y. Ong, Nadeem Hayat Mallick, Syed Zahed Rasheed, Eric L. Harshfield, Angela M. Wood, Taniya Sattar, John Danesh, Fazal-ur-Rehman Memon, David Stacey, Shahid Abbas, Zameer-ul-Asar, Anis Memon, Zia Yaqub, Imran Saleem, Asif Rasheed, Albert Koulman, Anjum Jalal, M. Ishaq, Tahir Saghir, Adam S. Butterworth, Daniel Ziemek, Julian L. Griffin, Nadeem Qamar

BackgroundGenetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::807ea6cf95fa8ec9c595917b00c7c3ff
https://doi.org/10.1101/2020.10.16.20213520

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis

Autor: Joseph L. Witztum, Zia Yaqoob, Santica M. Marcovina, Manjinder S. Sandhu, Asif Rasheed, Danish Saleheen, Sotirios Tsimikas, Faisal Majeed, Atif Imran, Fazal-ur-Rehman Memon, Khan Shah Zaman, Philippe M. Frossard, Anis Memon, Daniel J. Rader, Syed Zahed Rasheed, Naveeduddin Ahmed, Saba Akhtar, John Danesh, M. Ishaq, Tahir Saghir, Syed Nadeem Hasan Rizvi, Adam Taleb, Nadeem Qamar, Philip C Haycock, Wei Zhao, Nadeem Hayyat Mallick, Shahid Abbas, Khalid Mahmood

Publikováno v: The Lancet. Diabetes & Endocrinology
Saleheen, D, Haycock, P C, Zhao, W, Rasheed, A, Taleb, A, Imran, A, Abbas, S, Majeed, F, Akhtar, S, Qamar, N, Zaman, K S, Yaqoob, Z, Saghir, T, Rizvi, S N H, Memon, A, Mallick, N H, Ishaq, M, Rasheed, S Z, Memon, F-R, Mahmood, K, Ahmed, N, Frossard, P, Tsimikas, S, Witztum, J L, Marcovina, S, Sandhu, M, Rader, D J & Danesh, J 2017, ' Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease : a mendelian randomisation analysis ', Lancet Diabetes and Endocrinology, vol. 5, no. 7, pp. 524-533 . https://doi.org/10.1016/S2213-8587(17)30088-8

Background The lipoprotein(a) pathway is a causal factor in coronary heart disease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway, apolipoprotein(a) isoform size and circulating lipoprotein(a) conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba38c683440c76ff69feaf3356ceeed2
https://www.repository.cam.ac.uk/handle/1810/269291