Zobrazeno 1 - 10
of 752
pro vyhledávání: '"Fayyaz S"'
Autor:
Savannah Sawaged, Thomas Mota, Honit Piplani, Reetu Thakur, Deepti Lall, Elizabeth McCabe, Soojung Seo, Fayyaz S Sutterwala, Ralph Feuer, Roberta A Gottlieb, Jon Sin
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010350 (2022)
Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis. Much like
Externí odkaz:
https://doaj.org/article/e696c9c12bf5439ba9dabcd41437eaa3
Autor:
Tiffany Y Borbón, Breanna M Scorza, Gwendolyn M Clay, Fellipe Lima Nobre de Queiroz, Alan J Sariol, Jayden L Bowen, Yani Chen, Bayan Zhanbolat, Corey P Parlet, Diogo G Valadares, Suzanne L Cassel, William M Nauseef, Alexander R Horswill, Fayyaz S Sutterwala, Mary E Wilson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007247 (2019)
Cutaneous leishmaniasis (CL) is a parasitic disease causing chronic, ulcerating skin lesions. Most humans infected with the causative Leishmania protozoa are asymptomatic. Leishmania spp. are usually introduced by sand flies into the dermis of mammal
Externí odkaz:
https://doaj.org/article/d356486971d14c3ab0729d9b3e40b87f
Autor:
Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler, Kathleen A. M. Mills, Ann M. Janowski, A. Paige Davis Volk, Kai Wang, Kevin L. Legge, Lokesh Gakhar, Mohammed Bourdi, Polly J. Ferguson, Mary E. Wilson, Suzanne L. Cassel, Fayyaz S. Sutterwala
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missen
Externí odkaz:
https://doaj.org/article/383567b1d23c49cca2e3d2f968f86070
Autor:
Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting
Externí odkaz:
https://doaj.org/article/8dc39d9da6c541818c16001eb4cc7191
Autor:
Xiaowei Wang, Dana K Shaw, Holly L Hammond, Fayyaz S Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J Perkins, Joseph V Bonventre, Thangam S Velayutham, Sean M Evans, Kyle G Rodino, Lauren VieBrock, Karen M Scanlon, Nicholas H Carbonetti, Jason A Carlyon, Edward A Miao, Jere W McBride, Michail Kotsyfakis, Joao H F Pedra
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005803 (2016)
Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular bacteria. Due to these molecular features, the order Rickettsiales can be used to uncover br
Externí odkaz:
https://doaj.org/article/130f8b62410e47cdafb35a596bcc86c1
Autor:
Ceren Ciraci, John R Janczy, Nidhi Jain, Stefanie Haasken, Cyntia Pecli E Silva, Claudia F Benjamim, Jeffrey J Sadler, Alicia K Olivier, Yoichiro Iwakura, Dmitry M Shayakhmetov, Fayyaz S Sutterwala, Suzanne L Cassel
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151252 (2016)
The precise context in which the innate immune system is activated plays a pivotal role in the subsequent instruction of CD4+ T helper (Th) cell responses. Th1 responses are downregulated when antigen is encountered in the presence of antigen-IgG imm
Externí odkaz:
https://doaj.org/article/5657ace81c584fdfa921b08750bbdbe3
Autor:
Fang Yuan, Ryan Kolb, Gaurav Pandey, Wei Li, Lin Sun, Fuyou Liu, Fayyaz S Sutterwala, Yinghong Liu, Weizhou Zhang
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164135 (2016)
Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide but current treatments remain suboptimal. The role of inflammation in DN has only recently been recognized. It has been shown that the NLRP3-inflammasome contributes
Externí odkaz:
https://doaj.org/article/88115779a2c74d66bd7355e24dc9c373
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004139 (2014)
Externí odkaz:
https://doaj.org/article/c51ca875424d474eacf7a2fe56288d23
Autor:
Wilco P Pulskens, Loes M Butter, Gwendoline J Teske, Nike Claessen, Mark C Dessing, Richard A Flavell, Fayyaz S Sutterwala, Sandrine Florquin, Jaklien C Leemans
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85775 (2014)
Progressive renal disease is characterized by tubulo-interstitial injury with ongoing inflammation and fibrosis. The Nlrp3 inflammasome contributes to these pathophysiological processes through its canonical effects in cytokine maturation. Nlrp3 may
Externí odkaz:
https://doaj.org/article/0524e48a0d334abe8297ad94bf16c189
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleu
Externí odkaz:
https://doaj.org/article/e1c7d21264424ee1a10f24e5dd4ccb5d