Prophylactic treatment with PEGylated bovine IFNλ3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle

Autor: Sarah E. Attreed, Christina Silva, Monica Rodriguez-Calzada, Aishwarya Mogulothu, Sophia Abbott, Paul Azzinaro, Peter Canning, Lillian Skidmore, Jay Nelson, Nick Knudsen, Gisselle N. Medina, Teresa de los Santos, Fayna Díaz-San Segundo

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

Foot-and-mouth disease (FMD) is a vesicular disease of cloven-hoofed animals with devastating economic implications. The current FMD vaccine, routinely used in enzootic countries, requires at least 7 days to induce protection. However, FMD vaccinatio

Externí odkaz: https://doaj.org/article/3ee70f9a70464224baed98e2e52dc037

The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity

Autor: Gisselle N. Medina, Fayna Díaz-San Segundo, Carolina Stenfeldt, Jonathan Arzt, Teresa de los Santos

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Like all pathogens, foot-and-mouth disease virus (FMDV) is recognized by the immune system inducing a heightened immune response mainly mediated by type I and type III IFNs. To overcome the strong antiviral response induced by these cytokines, FMDV h

Externí odkaz: https://doaj.org/article/9c4264f04ad748d5899ef43214390760

Generation of Replication Deficient Human Adenovirus 5 (Ad5) Vectored FMD Vaccines

Autor: Gisselle N, Medina, Teresa, de Los Santos, Fayna, Díaz-San Segundo

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2465

Adenovirus vectors offer a convenient platform for the expression of antigens and have become an attractive system for vaccine development. Currently, the most successful approach to the development of new foot-and-mouth disease (FMD) vaccines has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d3623d954dcb470ddfe32b72ee76a61
https://pubmed.ncbi.nlm.nih.gov/35118621

Interaction between FMDV L

Autor: Gisselle N, Medina, Giselle M, Knudsen, Alexander L, Greninger, Anna, Kloc, Fayna, Díaz-San Segundo, Elizabeth, Rieder, Marvin J, Grubman, Joseph L, DeRisi, Teresa, de Los Santos

Publikováno v: Virology. 505

The foot-and-mouth disease virus (FMDV) leader protease (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0187cfd0256969e8c25272de5df8527f
https://pubmed.ncbi.nlm.nih.gov/28219017

Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice

Autor: Joaquín Castilla, Elia Alamillo, Maria Eugenia Herva, Juan Carlos Espinosa, Olivier Andreoletti, Fayna Díaz San-Segundo, Séverine Lugan, Jan P. M. Langeveld, Juan María Torres, Mónica Morales, Francisco J. Salguero, Caroline Lacroux

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2007, 81 (2), pp.835-843. ⟨10.1128/JVI.01356-06⟩
Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
INIA: Repositorio de Resultados de Investigación del INIA
Journal of Virology, 81(2), 835-843
Journal of Virology 81 (2007) 2

Sheep can be experimentally infected with bovine spongiform encephalopathy (BSE), and the ensuing disease is similar to scrapie in terms of pathogenesis and clinical signs. BSE infection in sheep is an animal and human health concern. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704fc86211fbd9007e8d2e85f472dc1e
https://hal.inrae.fr/hal-02666263