Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Faye J. Sheen"'
Autor:
Sarah E. Brewer, Ed Cleator, Debra J. Wallace, Paulo Avalle, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Matthew M. Bio, Antony J. Davies, Gavin W. Stewart, Robert D. Wilson
Publikováno v:
Organic Process Research & Development. 17:1561-1567
The process development and multikilogram preparation of a TRPV1 antagonist, 1, is described. Pyrido[2,3-b]pyrazine 1 was prepared in a convergent manner by the coupling of two key fragments, glyoxal 2 and diamine 3. Glyoxal 2 was synthesized in six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55245a654caf02dc06470afc8eea876
https://doi.org/10.1021/op400304h
https://doi.org/10.1021/op400304h
Autor:
Brian C. Bishop, Mark McLaughlin, Jingjun Yin, Ed Cleator, Cheng Chen, Faye J. Sheen, Adrian Goodyear, Yingju Xu, Gavin W. Stewart, Xin Linghu
Publikováno v:
Organic Process Research & Development. 16:605-611
A new synthetic route has been developed to drug candidate 1, a second-generation NNRTI being developed as a potential treatment of HIV. Regiocontrol in a key alkylation step was achieved by selective N-alkylation of hydrazone 13. After a deprotectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e71082c3fd033c00e7770f2e06559a1
https://doi.org/10.1021/op200334x
https://doi.org/10.1021/op200334x
Autor:
Faye J. Sheen, Neil A. Strotman, Carl A. Baxter, Robert A. Reamer, Debra J. Wallace, Ed Cleator, Karel M. J. Brands, Gavin W. Stewart, John S. Edwards
Publikováno v:
Organic Process Research & Development. 15:367-375
A new synthetic route to drug candidate 1, a potent and selective dual orexin antagonist for the treatment of sleep disorders, has been developed. The key acyclic precursor 10 was prepared in a one-step process in 75% isolated yield from commercially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d52e92328dad7b86400d717810acb7c2
https://doi.org/10.1021/op1002853
https://doi.org/10.1021/op1002853
Autor:
Michael P. O'Hagan, Gavin W. Stewart, Ed Cleator, Carl A. Baxter, Timothy J. C. O'Riordan, Faye J. Sheen
Publikováno v:
Tetrahedron Letters. 51:1079-1082
A simple one-pot synthesis of benzoxathiazepine-1,1-dioxides is described. Increased yields are afforded when suitable substituents are present in one of the starting materials. These additional substituents also provide a handle for further function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4035843e02c9e96d0043637dd25ba54d
https://doi.org/10.1016/j.tetlet.2009.12.099
https://doi.org/10.1016/j.tetlet.2009.12.099
Autor:
Robert D. Wilson, Matthew M. Bio, Antony J. Davies, Faye J. Sheen, Andy Lawrence, Gavin W. Stewart, Ed Cleator, Simon E. Hamilton
Publikováno v:
Tetrahedron. 65:8950-8955
The development of a synthetically useful, regioselective cross-coupling of 2,4-diaminopyridines with aryl and heteroaryl halides is reported. Selectivity for coupling through either amine is controlled by a simple change in the reaction conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2536eb25511d40b7f1088003e3b2030d
https://doi.org/10.1016/j.tet.2009.08.056
https://doi.org/10.1016/j.tet.2009.08.056
Autor:
Robert D. Wilson, George Zhou, Antony J. Davies, Gavin W. Stewart, Karel M. J. Brands, David Hands, Steven F. Oliver, Michael S. Ashwood, Robert A. Reamer, Ed Cleator, Matthew M. Bio, Ulf-H. Dolling, Khateeta M. Emerson, Faye J. Sheen, Arlene E. Mckeown, Andrew D. Gibb
Publikováno v:
Organic Process Research & Development. 13:543-547
A practical and efficient synthesis of 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole, 1, is described. A new one-pot process has been developed, starting from the commercially availa...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189b5b874e3f609e10aad2d368739b31
https://doi.org/10.1021/op800290t
https://doi.org/10.1021/op800290t
Autor:
Ulf-H. Dolling, Antony J. Davies, K. M. Jos Brands, Matthew M. Bio, Faye J. Sheen, Ed Cleator
Publikováno v:
Tetrahedron Letters. 47:4245-4248
A novel and efficient synthesis of a range of racemic and enantioenriched N-substituted-4-substituted isothiazolidine-1,1-dioxides from epoxides and sulfonamides is described. The critical choice of the activating group for the cyclization event is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0161458aec1af8db82438fd5e34988
https://doi.org/10.1016/j.tetlet.2006.04.038
https://doi.org/10.1016/j.tetlet.2006.04.038
Autor:
Antony J. Davies, Karel M. J. Brands, Sarah E. Brewer, Robert D. Wilson, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Ulf-H. Dolling, David Hands, Stephen P. Keen, Robert A. Reamer, Steven F. Oliver
Publikováno v:
The Journal of Organic Chemistry. 71:3086-3092
A practical asymmetric synthesis of the gamma-secretase inhibitor (-)-1 is described. As the key transformation, a highly diastereoselective intramolecular nitrile oxide cycloaddition forms the hexahydrobenzisoxazole core of 3 in four operations. Oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f032407119fcad06ff980eed48c48c77
https://doi.org/10.1021/jo060033i
https://doi.org/10.1021/jo060033i
Autor:
Ed Cleator, Michael P. O'Hagan, Gavin W. Stewart, Faye J. Sheen, Timothy J. C. O'Riordan, Carl A. Baxter
Publikováno v:
ChemInform. 41
A simple one-pot synthesis of benzoxathiazepine-1,1-dioxides is described. Increased yields are afforded when suitable substituents are present in one of the starting materials. These additional substituents also provide a handle for further function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6520f92fe69d448ee09e360d6c8efc03
https://doi.org/10.1002/chin.201020155
https://doi.org/10.1002/chin.201020155
Autor:
Antony J. Davies, Andy Lawrence, Matthew M. Bio, Robert D. Wilson, Ed Cleator, Gavin W. Stewart, Simon E. Hamilton, Faye J. Sheen
Publikováno v:
ChemInform. 41
The development of a synthetically useful, regioselective cross-coupling of 2,4-diaminopyridines with aryl and heteroaryl halides is reported. Selectivity for coupling through either amine is controlled by a simple change in the reaction conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f1a10fbba2000669320f3610709654
https://doi.org/10.1002/chin.201008148
https://doi.org/10.1002/chin.201008148