Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Faye A, Rogers"'
Autor:
Peter M. Glazer, Faye A. Rogers, Daniel A. Colon-Rios, Yanfeng Liu, Adam Krysztofiak, Jonathan Dow
SFig 1: SAHA reduces H3K9 trimethylation in IDH1 mutant cells while increasing H3K9 and H4 acetylation, SFig 2: Characterization of U2OS EJDR cells after SAHA, metabolite and siRNA treatment, SFig 3: SAHA elevates DNA damage to a greater degree in ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd453ad8f5ff879de20c6b02edaa6d5f
https://doi.org/10.1158/1541-7786.22527809.v1
https://doi.org/10.1158/1541-7786.22527809.v1
Autor:
Yanfeng Liu, Adam Krysztofiak, Cynthia Chan, Meetu Kaushik Tiwari, W. Mark Saltzman, Daniel A. Colon-Rios, Eric Song, Elias Quijano, Hee-Won Suh, Hemanta C. Rao Tumu, Demetrios T. Braddock, Faye A. Rogers
Publikováno v:
Nature Biotechnology. 40:325-334
Gene amplification drives oncogenesis in a broad spectrum of cancers. A number of drugs have been developed to inhibit the protein products of amplified driver genes, but their clinical efficacy is often hampered by drug resistance. Here, we introduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16eab5a1ec655a01c887a2d05d983e34
https://doi.org/10.1038/s41587-021-01057-5
https://doi.org/10.1038/s41587-021-01057-5
Autor:
Jonathan Dow, Daniel A. Colon-Rios, Adam Krysztofiak, Faye A. Rogers, Peter M. Glazer, Yanfeng Liu
Publikováno v:
Mol Cancer Res
Exploitation of DNA repair defects has enabled major advances in treating specific cancers. Recent work discovered that the oncometabolite 2-hydroxyglutarate (2-HG), produced by neomorphic isocitrate dehydrogenase 1/2 (IDH1/2) mutations, confers a ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c483d763c6fba50e4d28f8adacd7d37
https://europepmc.org/articles/PMC8642278/
https://europepmc.org/articles/PMC8642278/
Autor:
Scott A. Strobel, Daniel Spakowicz, Meetu Kaushik Tiwari, Jason M. Crawford, Hyun Bong Park, Nneoma Adaku, Faye A. Rogers
Publikováno v:
Journal of natural products. 83(6)
Disruption of the tumor suppressor PTEN, either at the protein or genomic level, plays an important role in human cancer development. The high frequency of PTEN deficiency reported across several cancer subtypes positions therapeutic approaches that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce24cbb9a06fcf6d5c14bf4bb1c87d
https://pubmed.ncbi.nlm.nih.gov/32407116
https://pubmed.ncbi.nlm.nih.gov/32407116
Autor:
Meetu, Kaushik Tiwari, Daniel A, Colon-Rios, Hemanta C Rao, Tumu, Yanfeng, Liu, Elias, Quijano, Adam, Krysztofiak, Cynthia, Chan, Eric, Song, Demetrios T, Braddock, Hee-Won, Suh, W Mark, Saltzman, Faye A, Rogers
Publikováno v:
Nature biotechnology. 40(3)
Gene amplification drives oncogenesis in a broad spectrum of cancers. A number of drugs have been developed to inhibit the protein products of amplified driver genes, but their clinical efficacy is often hampered by drug resistance. Here, we introduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a23b6f041a99eca550759bd2451622a
https://pubmed.ncbi.nlm.nih.gov/34711990
https://pubmed.ncbi.nlm.nih.gov/34711990
Publikováno v:
Nucleic Acids Research
Structural alterations in DNA can serve as natural impediments to replication fork stability and progression, resulting in DNA damage and genomic instability. Naturally occurring polypurine mirror repeat sequences in the human genome can create endog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5947e9b56c8ad4b01daee8b0e61e56b8
https://doi.org/10.1093/nar/gkw515
https://doi.org/10.1093/nar/gkw515
Publikováno v:
European Journal of Protistology. 49:575-589
Hyalophysa chattoni, borne as an encysted phoront on a crustacean's exoskeleton, metamorphoses to the trophont during the host's premolt. After the molt within 15 min to 2 h conjugants with food vacuoles appear in the exuvium, swimming along with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5661fbe105614a7884efdfd3f4b0da80
https://doi.org/10.1016/j.ejop.2013.02.002
https://doi.org/10.1016/j.ejop.2013.02.002
Autor:
Meetu Kaushik Tiwari, Faye A. Rogers
Publikováno v:
Nucleic Acids Research
DNA sequences capable of forming triplexes are prevalent in the human genome and have been found to be intrinsically mutagenic. Consequently, a balance between DNA repair and apoptosis is critical to counteract their effect on genomic integrity. Usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddf7ee0d87f412acdcae1e4939f4818
http://europepmc.org/articles/PMC3799437
http://europepmc.org/articles/PMC3799437
Publikováno v:
The Journal of investigative dermatology
Epidermal keratinocytes are particularly suitable candidates for in situ gene correction. Intraperitoneal administration of a triplex-forming oligonucleotide (TFO) was previously shown to introduce DNA base changes in a reporter gene in skin, without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b8f99a5d404d066e39ebcd02095be
Autor:
Robyn P. Hickerson, Christopher H. Contag, Faye A. Rogers, Tycho Speaker, Leonard M. Milstone, Manuel A. Flores, Roger L. Kaspar, Emilio Gonzalez-Gonzalez
Publikováno v:
Methods in Molecular Biology ISBN: 9781493931477
Monogenic skin diseases arise from well-defined single gene mutations, and in some cases a single point mutation. As the target cells are superficial, these diseases are ideally suited for treatment by nucleic acid-based therapies as well as monitori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ccfd2c2afe8045549454d6b08609c3
https://doi.org/10.1007/978-1-4939-3148-4_1
https://doi.org/10.1007/978-1-4939-3148-4_1