The metabolism of cells regulates their sensitivity to NK cells depending on p53 status

Autor: Sana Belkahla, Joaquin Marco Brualla, Alexis Fayd’herbe de Maudave, Paolo Falvo, Nerea Allende-Vega, Michael Constantinides, Abrar Ul Haq Khan, Lois Coenon, Catherine Alexia, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Wissem Mnif, Javier Hernandez, Alberto Anel, Martin Villalba

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymph

Externí odkaz: https://doaj.org/article/0a6c7e5f1a1d4f84b4d02628999b7b05

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

Autor: Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of sol

Externí odkaz: https://doaj.org/article/80ab263158524947a4f42174b3b1b555

Non-Genetically Improving the Natural Cytotoxicity of Natural Killer (NK) Cells

Autor: Martin Villalba, Catherine Alexia, Anais Bellin-Robert, Alexis Fayd'herbe de Maudave, Delphine Gitenay

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

The innate lymphocyte lineage natural killer (NK) is now the target of multiple clinical applications, although none has received an agreement from any regulatory agency yet. Transplant of naïve NK cells has not proven efficient enough in the vast m

Externí odkaz: https://doaj.org/article/46b50563e09a455b89f8e28991a043b9

Direct Cell Death Induced by CD20 Monoclonal Antibodies on B Cell Lymphoma Cells Revealed by New Protocols of Analysis

Autor: Michael Constantinides, Alexis Fayd’herbe De Maudave, Marie Potier-Cartereau, Mauricio Campos-Mora, Guillaume Cartron, Martin Villalba

Publikováno v: Cancers
Volume 15
Issue 4
Pages: 1109

CD20 monoclonal antibodies (mAbs) eliminate B cells in several clinical contexts. At least two of these Abs, obinutuzumab (OBI) and rituximab (RTX), induce quick elimination of targets and put cancer patients at risk of tumor lysis syndrome (TLS) wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08690b61b43de90a7a88117ce9a44ab0
https://doi.org/10.3390/cancers15041109

Metformin Sensitizes Leukemic Cells to Cytotoxic Lymphocytes by Increasing Expression of Intercellular Adhesion Molecule-1 (ICAM-1)

Autor: Martin Villalba, Francesco Bertolini, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Alexis Fayd'herbe de Maudave, Paul Massa, Stefania Orecchioni, Nerea Allende-Vega, Lois Coenon, Delphine Gitenay, Michael Constantinides, Isabel Marzo, Alberto Anel, Giulia Mitola

Publikováno v: Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Scientific Reports, Nature Publishing Group, 2022, 12 (1), pp.1341. ⟨10.1038/s41598-022-05470-x⟩

Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The antidiabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of solid cancers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f0e5b852a683f500ab3453969cc403
https://doi.org/10.21203/rs.3.rs-830815/v2