Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Faycal Guedj"'
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
BackgroundMaternal over- and undernutrition in pregnancy plays a critical role in fetal brain development and function. The effects of different maternal diet compositions on intrauterine programing of the fetal brain is a lesser-explored area. The g
Externí odkaz:
https://doaj.org/article/4ef6083514fb4b5bbf27c8b2a4ffa715
Autor:
Nadine M. Aziz, Faycal Guedj, Jeroen L. A. Pennings, Jose Luis Olmos-Serrano, Ashley Siegel, Tarik F. Haydar, Diana W. Bianchi
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit
Externí odkaz:
https://doaj.org/article/4afb9f40e6dd49c0acc6497a27082010
Autor:
Millie A Ferrés, Diana W Bianchi, Ashley E Siegel, Roderick T Bronson, Gordon S Huggins, Faycal Guedj
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168009 (2016)
The Ts1Cje model of Down syndrome is of particular interest for perinatal studies because affected males are fertile. This permits affected pups to be carried in wild-type females, which is similar to human pregnancies. Here we describe the early nat
Externí odkaz:
https://doaj.org/article/e7453e6f014f4bdeb403b72d32197a98
Publikováno v:
Journal of Neuroscience Research. 101:492-507
Several non-verbal cognitive and behavioral tests have been developed to assess learning deficits in humans with Down syndrome (DS). Here we used rodent touchscreen paradigms in adult male mice to investigate visual discrimination (VD) learning and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d55f88acd995e1c39dc1ae88ac3619c
https://doi.org/10.1002/jnr.25160
https://doi.org/10.1002/jnr.25160
Autor:
Faycal Guedj, Elise Kane, Lauren A. Bishop, Jeroen L. A. Pennings, Yann Herault, Diana W. Bianchi
Despite many successful preclinical treatment studies to improve neurocognition in the Ts65Dn mouse model of Down syndrome (DS), translation to humans has failed. This raises critical questions about the appropriateness of the Ts65Dn mouse as the “
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5692ae7863b3c2b421582373f6ff4f
https://doi.org/10.1101/2022.09.23.509067
https://doi.org/10.1101/2022.09.23.509067
Publikováno v:
Trends Mol Med
While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinical trials to improve cognition in individuals with DS has had a poor success record. Timing of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ede01247b85c6a801e8ef5ddb48204
https://doi.org/10.1016/j.molmed.2019.10.001
https://doi.org/10.1016/j.molmed.2019.10.001
Autor:
Fatimah Alsebaa, Lauren J. Massingham, Diana W. Bianchi, Umadevi Tantravahi, Faycal Guedj, Ashley E Siegel, Jeroen L. A. Pennings
Publikováno v:
Am J Hum Genet
Human fetuses with trisomy 21 (T21) have atypical brain development that is apparent sonographically in the second trimester. Prenatal diagnosis provides a potential opportunity to begin treatment in utero. We hypothesize that by analyzing and integr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13b5dfd471e00118483e488182fba9d
http://hdl.handle.net/10029/624466
http://hdl.handle.net/10029/624466
Humans with Down syndrome (DS) exhibit hippocampal learning deficits in the Cambridge Neuropsychological Test Automated Battery (CANTAB). Here we translated the CANTAB Visual Discrimination (VD) and Extinction tasks to investigate hippocampal learnin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d11e56e75023207f35268292ff35a84
https://doi.org/10.1101/2020.07.21.214106
https://doi.org/10.1101/2020.07.21.214106
Publikováno v:
American Journal of Obstetrics and Gynecology. 225:296.e1-296.e13
Background In human fetuses with Down syndrome, placental pathology, structural anomalies and growth restriction are present. There is currently a significant lack of information regarding the early life span in mouse models of Down syndrome. Objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfde154adbfde9428b4f4dfae6ed153
https://doi.org/10.1016/j.ajog.2021.03.019
https://doi.org/10.1016/j.ajog.2021.03.019