Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Fayçal Guedj"'
Autor:
Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 65-75 (2014)
Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine
Externí odkaz:
https://doaj.org/article/38eb53d8da744590b164b4cc0d3230c4
Autor:
Fayçal Guedj, Patricia Lopes Pereira, Sonia Najas, Maria-Jose Barallobre, Caroline Chabert, Benoit Souchet, Catherine Sebrie, Catherine Verney, Yann Herault, Mariona Arbones, Jean M. Delabar
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 190-203 (2012)
Copy number variation in a small region of chromosome 21 containing DYRK1A produces morphological and cognitive alterations in human. In mouse models, haploinsufficiency results in microcephaly, and a human DYRK1A gain-of-function model (three allele
Externí odkaz:
https://doaj.org/article/db3d5b2c8d124690bf6c0cdc300b6366
Autor:
Fayçal Guedj, Patricia Lopes Pereira, Sonia Najas, Maria-Jose Barallobre, Caroline Chabert, Benoit Souchet, Catherine Sebrie, Catherine Verney, Yann Herault, Mariona Arbones, Jean M. Delabar
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 2, Pp 294- (2012)
Externí odkaz:
https://doaj.org/article/67b1996ba157405a88f4a92f84058155
Autor:
Christophe Noll, Chris Planque, Clémentine Ripoll, Fayçal Guedj, Anna Diez, Véronique Ducros, Nicole Belin, Arnaud Duchon, Jean-Louis Paul, Anne Badel, Bénédicte de Freminville, Yann Grattau, Henri Bléhaut, Yann Herault, Nathalie Janel, Jean-Maurice Delabar
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7540 (2009)
BACKGROUND:Hyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosi
Externí odkaz:
https://doaj.org/article/a94d4700836043619d53e9078d9d582e
Autor:
Fayçal Guedj, Catherine Sébrié, Isabelle Rivals, Aurelie Ledru, Evelyne Paly, Jean C Bizot, Desmond Smith, Edward Rubin, Brigitte Gillet, Mariona Arbones, Jean M Delabar
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4606 (2009)
Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down s
Externí odkaz:
https://doaj.org/article/1ba254d4f4df43dbbfdf94462625276f
Autor:
Benoit Souchet, Fayçal Guedj, Nathalie Janel, Jillian Iafrati, Olivier Lassalle, Olivier J. Manzoni, Pascale Chavis, Aurore Thomazeau, Jean Maurice Delabar
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, 2014, 34 (4), pp.1138-1147. ⟨10.1523/JNEUROSCI.2852-13.2014⟩
Journal of Neuroscience, 2014, 34 (4), pp.1138-1147. ⟨10.1523/JNEUROSCI.2852-13.2014⟩
The geneDyrk1ais the mammalian ortholog of Drosophilaminibrain. Dyrk1alocalizes in the Down syndrome (DS) critical region of chromosome 21q22.2 and is a major candidate for the behavioral and neuronal abnormalities associated with DS. PFC malfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bb911e119909dda8634b64e4d52dec
https://pubmed.ncbi.nlm.nih.gov/24453307
https://pubmed.ncbi.nlm.nih.gov/24453307
Publikováno v:
Cellular & Molecular Neurobiology; Nov2023, Vol. 43 Issue 8, p3943-3963, 21p
Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.
Autor:
Planque, Chris, Dairou, Julien, Noll, Christophe, Bui, Linh-Chi, Ripoll, Clémentine, Guedj, Fayçal, Delabar, Jean-Maurice, Janel, Nathalie
Publikováno v:
Journal of Molecular Neuroscience; May2013, Vol. 50 Issue 1, p1-6, 6p
Autor:
Ilana Löwy
How has prenatal testing, once offered only for high-risk pregnancies, become standard medical care for pregnant women today?In the 1960s, thanks to the development of prenatal diagnosis, medicine found a new object of study: the living fetus. At fir
