Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Fawzi Khoder Agha"'
1
Akademický článek
Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons
Autor: Henriette Haukedal, Giulia I. Corsi, Veerendra P. Gadekar, Nadezhda T. Doncheva, Shekhar Kedia, Noortje de Haan, Abinaya Chandrasekaran, Pia Jensen, Pernille Schiønning, Sarah Vallin, Frederik Ravnkilde Marlet, Anna Poon, Carlota Pires, Fawzi Khoder Agha, Hans H. Wandall, Susanna Cirera, Anja Hviid Simonsen, Troels Tolstrup Nielsen, Jørgen Erik Nielsen, Poul Hyttel, Ravi Muddashetty, Blanca I. Aldana, Jan Gorodkin, Deepak Nair, Morten Meyer, Martin Røssel Larsen, Kristine Freude
Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)
Alzheimer’s disease (AD) is the most common cause of dementia, with no current cure. Consequently, alternative approaches focusing on early pathological events in specific neuronal populations, besides targeting the well-studied amyloid beta (Aβ)
Externí odkaz: https://doaj.org/article/4d6bdc2e3ad742debbe8defab51f61f4
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2
Akademický článek
A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I
Autor: Antti Hassinen, Fawzi Khoder-Agha, Elham Khosrowabadi, Daniela Mennerich, Deborah Harrus, Maxence Noel, Elitsa Y. Dimova, Tuomo Glumoff, Anne Harduin-Lepers, Thomas Kietzmann, Sakari Kellokumpu
Publikováno v: Redox Biology, Vol 24, Iss , Pp - (2019)
Glycosylation, a common modification of cellular proteins and lipids, is often altered in diseases and pathophysiological states such as hypoxia, yet the underlying molecular causes remain poorly understood. By utilizing lectin microarray glycan prof
Externí odkaz: https://doaj.org/article/412cfa2ca46241bdb0cf7f9892aaa153
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4
Akademický článek
How HIV-1 Integrase Associates with Human Mitochondrial Lysyl-tRNA Synthetase
Autor: Xaysongkhame Phongsavanh, Noha Al-Qatabi, Mohammed Samer Shaban, Fawzi Khoder-Agha, Merwan El Asri, Martine Comisso, Raphaël Guérois, Marc Mirande
Publikováno v: Viruses, Vol 12, Iss 10, p 1202 (2020)
Replication of human immunodeficiency virus type 1 (HIV-1) requires the packaging of tRNALys,3 from the host cell into the new viral particles. The GagPol viral polyprotein precursor associates with mitochondrial lysyl-tRNA synthetase (mLysRS) in a c
Externí odkaz: https://doaj.org/article/c797f6ea5702483f92ebd5e8de55599e
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5
Akademický článek
The dimeric structure of wild-type human glycosyltransferase B4GalT1.
Autor: Deborah Harrus, Fawzi Khoder-Agha, Miika Peltoniemi, Antti Hassinen, Lloyd Ruddock, Sakari Kellokumpu, Tuomo Glumoff
Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0205571 (2018)
Most glycosyltransferases, including B4GalT1 (EC 2.4.1.38), are known to assemble into enzyme homomers and functionally relevant heteromers in vivo. However, it remains unclear why and how these enzymes interact at the molecular/atomic level. Here, w
Externí odkaz: https://doaj.org/article/c31236d83f934f24a5bec6bf9cfb54f6
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6
Loss of USF2 promotes proliferation, migration and mitophagy in a redox-dependent manner
Autor: Fawzi Khoder-Agha, IIkka Miinalainen, Thomas Kietzmann, Sakari Kellokumpu, Daniela Mennerich, Elitsa Y. Dimova, Tabughang Franklin Chi
Publikováno v: Redox Biology
Redox Biology, Vol 37, Iss, Pp 101750-(2020)
The upstream stimulatory factor 2 (USF2) is a transcription factor implicated in several cellular processes and among them, tumor development seems to stand out. However, the data with respect to the role of USF2 in tumor development are conflicting
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9387a763ef99640673c5a7aa25594d
http://europepmc.org/articles/PMC7566946
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7
The glyco-redox interplay: Principles and consequences on the role of reactive oxygen species during protein glycosylation
Autor: Thomas Kietzmann, Fawzi Khoder-Agha
Publikováno v: Redox Biology
Redox Biology, Vol 42, Iss, Pp 101888-(2021)
Khoder-Agha, F & Kietzmann, T 2021, ' The glyco-redox interplay : Principles and consequences on the role of reactive oxygen species during protein glycosylation ', Redox Biology, vol. 42, 101888 . https://doi.org/10.1016/j.redox.2021.101888
Reactive oxygen species (ROS) carry out prime physiological roles as intracellular signaling agents, yet pathologically high concentrations of ROS cause irreversible damage to biomolecules, alter cellular programs and contribute to various diseases.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3b242e0a1820aefc6e54c1512d5eb7
https://doi.org/10.1016/j.redox.2021.101888
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8
Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains
Autor: Fawzi Khoder-Agha, Tuomo Glumoff, Anne Harduin-Lepers, Marc F. Lensink, Guillaume Brysbaert, Deborah Harrus, Sakari Kellokumpu
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (39), pp.14383-14393. ⟨10.1074/jbc.RA119.009539⟩
J Biol Chem
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, pp.jbc.RA119.009539. ⟨10.1074/jbc.RA119.009539⟩
Journal of Biological Chemistry, 2019, 294 (39), pp.14383-14393. ⟨10.1074/jbc.RA119.009539⟩
International audience; Edited by Gerald W. Hart ␤-1,4-Galactosyltransferase 1 (B4GALT1) and ST6 ␤-galac-toside ␣-2,6-sialyltransferase 1 (ST6GAL1) catalyze the successive addition of terminal ␤-1,4-linked galactose and ␣-2,6-linked sialic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fbc49d6bcacd95a9df8db9d86b708d
https://hal.archives-ouvertes.fr/hal-02343482
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9
A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I
Autor: Thomas Kietzmann, Deborah Harrus, Elham Khosrowabadi, Daniela Mennerich, Antti Hassinen, Sakari Kellokumpu, Anne Harduin-Lepers, Fawzi Khoder-Agha, Elitsa Y. Dimova, Tuomo Glumoff, Maxence Noel
Publikováno v: Redox Biology
Redox Biology, Elsevier, 2019, 24, pp.101182. ⟨10.1016/j.redox.2019.101182⟩
Redox Biology, 2019, 24, pp.101182. ⟨10.1016/j.redox.2019.101182⟩
Redox Biology, Vol 24, Iss, Pp-(2019)
Glycosylation, a common modification of cellular proteins and lipids, is often altered in diseases and pathophysiological states such as hypoxia, yet the underlying molecular causes remain poorly understood. By utilizing lectin microarray glycan prof
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9887b8f20e202b08d25f91aed31de963
http://europepmc.org/articles/PMC6454061
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10
N-acetylglucosaminyltransferases and nucleotide sugar transporters form multi-enzyme-multi-transporter assemblies in golgi membranes in vivo
Autor: Fawzi Khoder-Agha, Maria Escriva Conde, Paulina Sosicka, Tuomo Glumoff, Mariusz Olczak, Antti Hassinen, Sakari Kellokumpu
Publikováno v: Cellular and Molecular Life Sciences
Branching and processing of N-glycans in the medial-Golgi rely both on the transport of the donor UDP-N-acetylglucosamine (UDP-GlcNAc) to the Golgi lumen by the SLC35A3 nucleotide sugar transporter (NST) as well as on the addition of the GlcNAc resid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4084dd7cca9481862c7297fab4e2858a
https://static-content.springer.com/esm/art:10.1007/s00018-019-03032-5/MediaObjects/18_2019_3032_MOESM1_ESM.docx
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