Transplantation of IGF-1-induced BMSC-derived NPCs promotes tissue repair and motor recovery in a rat spinal cord injury model

Autor: Putri Nur Hidayah Al-Zikri, Tee Jong Huat, Amir Ali Khan, Azim Patar, Mohammed Faruque Reza, Fauziah Mohamad Idris, Jafri Malin Abdullah, Hasnan Jaafar

Publikováno v: Heliyon, Vol 8, Iss 8, Pp e10384- (2022)

Bone marrow-derived mesenchymal stem cells (BMSCs) have therapeutic potential for spinal cord injury (SCI). We have shown that insulin-like growth factor 1 (IGF-1) enhances the cellular proliferation and survivability of BMSCs-derived neural progenit

Externí odkaz: https://doaj.org/article/684a19c5e5a44c499c09250083775a6f

Rapamycin and PF4 Induce Apoptosis by Upregulating Bax and Down-Regulating Survivin in MNU-Induced Breast Cancer

Autor: Muhammad Irfan Abdul Jalal, Shazana Hilda Shamsuddin, Tengku Ahmad Damitri Al-Astani Tengku Din, Wan Nor Ariffin Wan Mansor, Hasnan Jaafar, Fauziah Mohamad Idris

Publikováno v: Asian Pacific Journal of Cancer Prevention. 15:3939-3944

Background: To elucidate the role of rapamycin and PF4 on apoptosis regulation via Bax (pro-apoptosis), Bcl-2 (anti-apoptosis) and survivin activation on the growth in the 1-methyl-1-nitrosourea -induced invasive breast carcinoma model. Materials and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde6f4b8b38b9e6916be3e61f33bc6e3
https://doi.org/10.7314/apjcp.2014.15.9.3939

IGF-1 Acts as Controlling Switch for Long-term Proliferation and Maintenance of EGF/FGF-responsive Striatal Neural Stem Cells

Autor: Soumya Pati, Zulkifli Mustafa, Jafri Malin Abdullah, Xu Han, Fauziah Mohamad Idris, Nor Entan Supeno, Abdul Rahman Izani Ghani, Hasnan Jaafar, Raisah Abdul Hadi

Publikováno v: International Journal of Medical Sciences

Background: Long-term maintenance of neural stem cells in vitro is crucial for their stage specific roles in neurogenesis. To have an in-depth understanding of optimal conditional microenvironmental niche for long-term maintenance of neural stem cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2739615860619d0e4bf6ec9feae57
https://doi.org/10.7150/ijms.5325

MicroRNA Expression Profile of Neural Progenitor-Like Cells Derived from Rat Bone Marrow Mesenchymal Stem Cells under the Influence of IGF-1, bFGF and EGF

Autor: Tee Jong Huat, Hasnan Jaafar, Jafri Malin Abdullah, Amir Ali Khan, Fauziah Mohamad Idris

Publikováno v: International Journal of Molecular Sciences
Volume 16
Issue 5
Pages 9693-9718
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 9693-9718 (2015)

Insulin-like growth factor 1 (IGF-1) enhances cellular proliferation and reduces apoptosis during the early differentiation of bone marrow derived mesenchymal stem cells (BMSCs) into neural progenitor-like cells (NPCs) in the presence of epidermal gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da81af2141a2cd0c63e1a6b40fae0ab

MicroRNA Profiling Reveals Unique miRNA Signatures in IGF-1 Treated Embryonic Striatal Stem Cell Fate Decisions in Striatal Neurogenesis In Vitro

Autor: Soumya Pati, Jafri Malin Abdullah, Sangu Muthuraju, Hasnan Jaafar, Abdul Rahman Izaini Ghani, Mirjana Maletic-Savatic, Raisah Abdul Hadi, Nor Entan Supeno, Fauziah Mohamad Idris

Publikováno v: BioMed Research International, Vol 2014 (2014)
BioMed Research International

The striatum is considered to be the central processing unit of the basal ganglia in locomotor activity and cognitive function of the brain. IGF-1 could act as a control switch for the long-term proliferation and survival of EGF + bFGF-responsive cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9aba8bca4e532e32c3403865cd6032
https://doaj.org/article/88fb43e46bae4822b369ab3bb4797ad1