Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

Autor: Lagae, Lieven, Sullivan, Joseph, Knupp, Kelly, Laux, Linda, Polster, Tilman, Nikanorova, Marina, Devinsky, Orrin, Cross, J. Helen, Guerrini, Renzo, Talwar, Dinesh, Miller, Ian, Farfel, Gail, Galer, Bradley S., Gammaitoni, Arnold, Mistry, Arun, Morrison, Glenn, Lock, Michael, Agarwal, Anupam, Lai, Wyman W., Ceulemans, Berten, Gill, Deepak, Riney, Kate, Scheffer, Ingrid, Buchhalter, Jeffrey, Carmant, Lionel, Connolly, Mary, Nabbout, Rima, Brandt, Ulrich, Jacobs-LeVan, Julia, Mayer, Thomas, Panzer, Axel, Pringsheim, Milka, Stephani, Ulrich, Wolff, Markus, Battaglia, Domenica, Beccaria, Francesca, Dana, Francesca, Granata, Tiziana, Romeo, Antonio, Striano, Pasquale, Vigevano, Federico, Gil-Nagel, Antonio, San Antonio, Victoria, Sanchez-Carpintero, Rocio, Desurkar, Archana, Hughes, Elaine, Lyer, Anand, Philip, Sunny, Zuberi, Sameer, Sharp, Gregory, Berenson, Frank, Faux, Linda, Marsh, Eric, Nespeca, Mark, Nahouraii, Robert, Paolicdii, Juliann, Phillips, Steven, Perry, Michael Scott, Poduri, Annapurna, Renfroe, Ben, Saneto, Russell, Shahid, Asim, Smith, Douglas, de Menezes, Marcio Sotero, Sweney, Matthew, Thiele, Elizabeth, Wheless, James, Wilfong, Angus, Wirrell, Elaine, Zupanc, Mary

Publikováno v: Lagae, L, Sullivan, J, Knupp, K, Laux, L, Polster, T, Nikanorova, M, Devinsky, O, Cross, J H, Guerrini, R, Talwar, D, Miller, I, Farfel, G, Galer, B S, Gammaitoni, A, Mistry, A, Morrison, G, Lock, M, Agarwal, A, Lai, W W, Ceulemans, B & FAiRE DS Study Group 2019, ' Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome : a randomised, double-blind, placebo-controlled trial ', The Lancet, vol. 394, no. 10216, pp. 2243-2254 . https://doi.org/10.1016/S0140-6736(19)32500-0
The lancet : international edition

Background Dravet syndrome is a rare, treatment-resistant developmental epileptic encephalopathy characterised by multiple types of frequent, disabling seizures. Fenfluramine has been reported to have antiseizure activity in observational studies of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118914f68610bc1f4b78289db7ff74b9
https://doi.org/10.1016/s0140-6736(19)32500-0