Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Fausto Machicao"'
Autor:
Xianming Wang, Michael Sterr, Ingo Burtscher, Shen Chen, Anja Hieronimus, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Gabriele Lederer, Thomas Meitinger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Michael Ray, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 57-68 (2018)
Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the fu
Externí odkaz:
https://doaj.org/article/1191a257d4294ce78a3966838b2d29b0
Autor:
Jan Rozman, Birgit Rathkolb, Manuela A. Oestereicher, Christine Schütt, Aakash Chavan Ravindranath, Stefanie Leuchtenberger, Sapna Sharma, Martin Kistler, Monja Willershäuser, Robert Brommage, Terrence F. Meehan, Jeremy Mason, Hamed Haselimashhadi, IMPC Consortium, Tertius Hough, Ann-Marie Mallon, Sara Wells, Luis Santos, Christopher J. Lelliott, Jacqueline K. White, Tania Sorg, Marie-France Champy, Lynette R. Bower, Corey L. Reynolds, Ann M. Flenniken, Stephen A. Murray, Lauryl M. J. Nutter, Karen L. Svenson, David West, Glauco P. Tocchini-Valentini, Arthur L. Beaudet, Fatima Bosch, Robert B. Braun, Michael S. Dobbie, Xiang Gao, Yann Herault, Ala Moshiri, Bret A. Moore, K. C. Kent Lloyd, Colin McKerlie, Hiroshi Masuya, Nobuhiko Tanaka, Paul Flicek, Helen E. Parkinson, Radislav Sedlacek, Je Kyung Seong, Chi-Kuang Leo Wang, Mark Moore, Steve D. Brown, Matthias H. Tschöp, Wolfgang Wurst, Martin Klingenspor, Eckhard Wolf, Johannes Beckers, Fausto Machicao, Andreas Peter, Harald Staiger, Hans-Ulrich Häring, Harald Grallert, Monica Campillos, Holger Maier, Helmut Fuchs, Valerie Gailus-Durner, Thomas Werner, Martin Hrabe de Angelis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulator
Externí odkaz:
https://doaj.org/article/7b0bd2741d2c4a34a03d78a177e5cce3
Autor:
Benjamin Assad Jaghutriz, Martin Heni, Stefan Zoltán Lutz, Louise Fritsche, Fausto Machicao, Harald Staiger, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Róbert Wagner
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Introduction: Genetic polymorphisms in TCF7L2 are the strongest common risk variants for type 2 diabetes mellitus (T2D). We and others have shown that genetic variation in TCF7L2 and WFS1 affect incretin-stimulated insulin secretion. A recent genome-
Externí odkaz:
https://doaj.org/article/3488b62a995147898d77cf608fa17450
Autor:
Xianming Wang, Shen Chen, Ingo Burtscher, Michael Sterr, Anja Hieronimus, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Gabriele Lederer, Thomas Meitinger, Heiko Lickert
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 273-276 (2016)
Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor PDX1 leads to pancreatic agenesis, whereas certain heterozygous point mutations are associated with Maturity-Onset Diabetes of the Young 4 (MODY4) and Type
Externí odkaz:
https://doaj.org/article/5443a81aa217468785114e3af5d3a38c
Autor:
Xianming Wang, Shen Chen, Ingo Burtscher, Michael Sterr, Anja Hieronimus, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Gabriele Lederer, Thomas Meitinger, Heiko Lickert
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 292-295 (2016)
Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor PDX1 leads to pancreatic agenesis, whereas certain heterozygous point mutations are associated with Maturity-Onset Diabetes of the Young 4 (MODY4) and Type
Externí odkaz:
https://doaj.org/article/8140f3055a2749a893ea94763506103f
Autor:
Corinna Sailer, Vera Schmid, Louise Fritsche, Tsvetelina Gerter, Fausto Machicao, Andreas Niess, Hans-Ulrich Häring, Norbert Stefan, Andreas Fritsche, Martin Heni
Publikováno v:
Obesity Facts, Vol 9, Iss 3, Pp 174-181 (2016)
Objective: Not every participant responds with a comparable body weight loss to lifestyle intervention, despite the same compliance. Genetic factors may explain parts of this difference. Variation in fat mass and obesity-associated gene (FTO) is the
Externí odkaz:
https://doaj.org/article/6b2a26e73af44a0e896939977696c0b6
Autor:
Anna-Maria Ordelheide, Nadja Gommer, Anja Böhm, Carina Hermann, Inga Thielker, Fausto Machicao, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger
Publikováno v:
Molecular Metabolism, Vol 5, Iss 4, Pp 305-316 (2016)
Objective: Circulating long-chain free fatty acids (FFAs) are important metabolic signals that acutely enhance fatty acid oxidation, thermogenesis, energy expenditure, and insulin secretion. However, if chronically elevated, they provoke inflammation
Externí odkaz:
https://doaj.org/article/32ee78b83d0544c6b5fb09013cd0f4a5
Autor:
Anja Böhm, Robert Wagner, Fausto Machicao, Jens Juul Holst, Baptist Gallwitz, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181880 (2017)
OBJECTIVE:Dipeptidyl-peptidase 4 (DPP-4) cleaves and inactivates the insulinotropic hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide, collectively termed incretins. DPP-4 inhibitors entered clinical practice as approved the
Externí odkaz:
https://doaj.org/article/8e6608e605054d0ca5fa73c41c692fa8
Autor:
Anna-Maria Ordelheide, Anja Böhm, Daniela Kempe-Teufel, Robert Wagner, Fausto Machicao, Martin Heni, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177148 (2017)
Inhibition of sodium/glucose cotransporter 2 (SGLT2), the key transport protein in renal glucose reabsorption, promotes glucose excretion and represents a new concept in the therapy of type-2 diabetes. In addition, SGLT2 inhibition elevates circulati
Externí odkaz:
https://doaj.org/article/28f1ebab32d4480da16d6af2012b91b0
Autor:
Fausto Machicao, Andreas Peter, Jürgen Machann, Ingmar Königsrainer, Anja Böhm, Stefan Zoltan Lutz, Martin Heni, Andreas Fritsche, Fritz Schick, Alfred Königsrainer, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145563 (2016)
Circadian rhythms govern vital functions. Their disruption provokes metabolic imbalance favouring obesity and type-2 diabetes. The aim of the study was to assess the role of clock genes in human prediabetes. To this end, genotype-phenotype associatio
Externí odkaz:
https://doaj.org/article/a5f4b2e8bbd84ecb8d0053f9e108751a