Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Fausto J. Rodriguez"'
Autor:
Michael Chang, Mohamed Sherief, Maria Ioannou, Viveka Chinnasamy, Lucy Chen, Michael Frost, Michelle Mattson-Hoss, Herb Sarnoff, David O. Kamson, Matthias Holdhoff, Debraj Mukherjee, Chetan Bettegowda, Jordina Rincon-Torroella, Victoria Croog, Peng Huang, Fausto J. Rodriguez, Calixto-Hope G. Lucas, Karisa C. Schreck
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas. NF1 loss may also be a harbinger of exploitable vulnerabilities in IDH-wildtype glioblastoma (GBM). Accura
Externí odkaz:
https://doaj.org/article/750d716ba61347bc87ffa9e517a87e9c
Autor:
Frank B. Furnari, Corina Anastasaki, Shan Bian, Howard A. Fine, Tomoyuki Koga, Lu Q. Le, Fausto J. Rodriguez, David H. Gutmann
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/ce1de40fcd154f57adc3a04a5aab3822
Autor:
Corina Anastasaki, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne M. Scheaffer, Amanda De Andrade Costa, Anna F. Wilson, Chloe M. Kernan, Ameera H. Zafar, Xia Ge, Joel R. Garbow, Fausto J. Rodriguez, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC)
Externí odkaz:
https://doaj.org/article/0bce5b7aff7c4c1bb0ec1923cf2a939e
Autor:
Antje Arnold, Eddie Luidy Imada, Lisa Zhang, Deepak P. Edward, Luigi Marchionni, Fausto J. Rodriguez
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Although most commonly benign, neurofibromas (NFs) can have devastating functional and cosmetic effects in addition to the possibility of malignant transformation. In orbitofacial neurofibromatosis type 1, NFs may cause progressive, disfigur
Externí odkaz:
https://doaj.org/article/6e12143f4e174ccba74144ce599218ce
Autor:
Dongyun Zhang, William H. Yong, Masoud Movassaghi, Fausto J. Rodriguez, Issac Yang, Paul McKeever, Jiang Qian, Jian Yi Li, Qinwen Mao, Kathy L. Newell, Richard M. Green, Cynthia T. Welsh, Anthony P. Heaney
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2842 (2022)
Neurocytomas are rare low-grade brain tumors predominantly affecting young adults, but their cellular origin and molecular pathogenesis is largely unknown. We previously reported a sellar neurocytoma that secreted excess arginine vasopressin causing
Externí odkaz:
https://doaj.org/article/1f7cecf9d5f842ad94a57f692b31c655
Autor:
Matthew A Smith-Cohn, Zied Abdullaev, Kenneth D. Aldape, Martha Quezado, Marc K. Rosenblum, Chad M. Vanderbilt, Fausto J. Rodriguez, John Laterra, Charles G. Eberhart
Publikováno v:
Free Neuropathology, Vol 2 (2021)
The majority of astroblastoma occur in a cerebral location in children and young adults. Here we describe the unusual case of a 38-year-old man found to have a rapidly growing cystic enhancing circumscribed brainstem tumor with high grade histopathol
Externí odkaz:
https://doaj.org/article/a0c1d1e14a9a45e2b27ce51789faaf31
Autor:
Fausto J. Rodriguez, Mindy K. Graham, Jacqueline A. Brosnan-Cashman, John R. Barber, Christine Davis, M. Adelita Vizcaino, Doreen N. Palsgrove, Caterina Giannini, Melike Pekmezci, Sonika Dahiya, Murat Gokden, Michael Noë, Laura D. Wood, Christine A. Pratilas, Carol D. Morris, Allan Belzberg, Jaishri Blakeley, Christopher M. Heaphy
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract The presence of Alternative lengthening of telomeres (ALT) and/or ATRX loss, as well as the role of other telomere abnormalities, have not been formally studied across the spectrum of NF1-associated solid tumors. Utilizing a telomere-specifi
Externí odkaz:
https://doaj.org/article/3454d938fe7347fc81ef6b72dd035460
Autor:
Carlos G. Romo, Doreen N. Palsgrove, Ananyaa Sivakumar, Christen R. Elledge, Lawrence R. Kleinberg, Kaisorn L. Chaichana, Christopher D. Gocke, Fausto J. Rodriguez, Matthias Holdhoff
Publikováno v:
Diagnostic Pathology, Vol 14, Iss 1, Pp 1-10 (2019)
Abstract Background Gliomas with 1p/19q-codeletion as well as mutation of isocitrate dehydrogenase (IDH) 1 are typically characterized as oligodendrogliomas with comparatively good response to treatment with radiation and chemotherapy. Case presentat
Externí odkaz:
https://doaj.org/article/7e1f5d2a9ad64279989e2c325510829f
Autor:
Carina Dehner, Chang In Moon, Xiyuan Zhang, Zhaohe Zhou, Chris Miller, Hua Xu, Xiaodan Wan, Kuangying Yang, Jay Mashl, Sara J.C. Gosline, Yuxi Wang, Xiaochun Zhang, Abigail Godec, Paul A. Jones, Sonika Dahiya, Himanshi Bhatia, Tina Primeau, Shunqiang Li, Kai Pollard, Fausto J. Rodriguez, Li Ding, Christine A. Pratilas, Jack F. Shern, Angela C. Hirbe
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
One of the most common malignancies affecting adults with Neurofibromatosis type 1 (NF1) is the malignant peripheral nerve sheath tumor (MPNST), an aggressive and often fatal sarcoma that commonly arises from benign plexiform neurofibromas. Despite a
Externí odkaz:
https://doaj.org/article/02174fc3c80343d29dc12bc04c3f1439
Autor:
Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying
Externí odkaz:
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca