Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Fausto G. Hegardt"'
Autor:
María Arnedo, Sebastián Menao, Beatriz Puisac, María E. Teresa-Rodrigo, María C. Gil-Rodríguez, Eduardo López-Viñas, Paulino Gómez-Puertas, Nuria Casals, César H. Casale, Fausto G. Hegardt, Juan Pié
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2046-2056 (2012)
A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine mature transcripts for the novel gene HMGCLL1, altho
Externí odkaz:
https://doaj.org/article/5844f0ad725743b480b2902a3d0484a1
Autor:
David Sebastián, Maria Guitart, Celia García-Martínez, Caroline Mauvezin, Josep M. Orellana-Gavaldà, Dolors Serra, Anna M. Gómez-Foix, Fausto G. Hegardt, Guillermina Asins
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1789-1799 (2009)
Carnitine palmitoyltransferase 1 (CPT1) catalyzes the first step in long-chain fatty acid import into mitochondria, and it is believed to be rate limiting for β-oxidation of fatty acids. However, in muscle, other proteins may collaborate with CPT1.
Externí odkaz:
https://doaj.org/article/069441f7ea6a4cedbed24ed50be6c5e5
Autor:
Corinne Lang, Markus Schäfer, Dolors Serra, Fausto G. Hegardt, Lukas Krähenbühl, Stephan Krähenbühl
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 1, Pp 22-30 (2001)
Rats with long-term cholestasis have reduced ketosis during starvation. Because it is unclear whether this is also the case in short-term cholestasis, we investigated hepatic fatty acid metabolism in rats with bile duct ligation for 5 days (BDL5, n =
Externí odkaz:
https://doaj.org/article/8c060f82fc8d4fa28501b3f25a1dd2db
Autor:
Ramon Colomer, Bellinda Benhamú, Peter Valent, Michael Wuczkowski, Nelly Auersperg, Reinhard Horvat, Jordi Garcia, Asha Leisser, Martin Filipits, Gerald Stübiger, Michael Grusch, María L. López-Rodríguez, Renate Wagner, Dolors Serra, Thomas W. Grunt, Daniel Veigel, Fausto G. Hegardt
Publikováno v:
International Journal of Cancer. 136:2078-2090
Ovarian cancer (OC) is caused by genetic aberrations in networks that control growth and survival. Importantly, aberrant cancer metabolism interacts with oncogenic signaling providing additional drug targets. Tumors overexpress the lipogenic enzyme f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb3f68dec69c55e9050d35e78641a0cd
https://doi.org/10.1002/ijc.29261
https://doi.org/10.1002/ijc.29261
Autor:
Mónica Ramos, Beatriz Puisac, Germaine Pierre, María Esperanza Teresa-Rodrigo, Gloria Bueno, Juan Pié, Sebastián Menao, Paulino Gómez-Puertas, María Concepción Gil-Rodríguez, Fausto G. Hegardt, María Teresa Echeverría Arnedo, María Hernández-Marcos, Uma Ramaswami, Carolina Baquero-Montoya, Cesar H. Casale
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
European Journal of Medical Genetics; Vol 56
instname
European Journal of Medical Genetics; Vol 56
Mitochondrial HMG-CoA synthase deficiency is a rare inherited metabolic disorder that affects ketone-body synthesis. Acute episodes include vomiting, lethargy, hepatomegaly, hypoglycaemia, dicarboxylic aciduria, and in severe cases, coma. This defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181394c2efc41078b9bf9c06a73c7cfb
https://doi.org/10.1016/j.ejmg.2013.05.008
https://doi.org/10.1016/j.ejmg.2013.05.008
Autor:
Laura Herrero, Xavier Ariza, Paula Mera, Guillermina Asins, Fausto G. Hegardt, Jordi Garcia, Dolors Serra, Kamil Makowski, David Paredes
Publikováno v:
Chirality. 25:281-287
C75 is a synthetic compound described as having antitumoral properties. It produces hypophagia and weight loss in rodents, limiting its use in cancer therapy but identifying it as a potential anti-obesity drug. C75 is a fatty acid synthase (FAS) inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e6514f819f0e5769991a68d8210edd
https://doi.org/10.1002/chir.22139
https://doi.org/10.1002/chir.22139
Autor:
Fausto G. Hegardt, Joan Francesc Mir, Kamil Makowski, Jordi Garcia, Paula Mera, Laura Herrero, Xavier Ariza, Dolors Serra, Guillermina Asins
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
C75 is a synthetic anticancer drug that inhibits fatty acid synthase (FAS) and shows a potent anorexigenic side effect. In order to find new cytotoxic compounds that do not impact food intake, we synthesized a new family of C75 derivatives. The most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0b3ac4cda3e8fef8e5134fb407a4ed
https://pubmed.ncbi.nlm.nih.gov/28324785
https://pubmed.ncbi.nlm.nih.gov/28324785
Autor:
Cèlia García-Martínez, Anna M. Gómez-Foix, Fausto G. Hegardt, Maria Guitart, Josep M. Orellana-Gavaldà, Guillermina Asins, Caroline Mauvezin, Dolors Serra, David Sebastián
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Lipid Research, Vol 50, Iss 9, Pp 1789-1799 (2009)
Journal of Lipid Research
Universidad de Barcelona
Journal of Lipid Research, Vol 50, Iss 9, Pp 1789-1799 (2009)
Journal of Lipid Research
Carnitine palmitoyltransferase 1 (CPT1) catalyzes the first step in long-chain fatty acid import into mitochondria, and it is believed to be rate limiting for beta-oxidation of fatty acids. However, in muscle, other proteins may collaborate with CPT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a30e184dffe0c43959813a1640f75c
https://doi.org/10.1194/jlr.m800535-jlr200
https://doi.org/10.1194/jlr.m800535-jlr200
Autor:
Timothy R. Koves, Robert M. Lust, Olga Ilkayeva, Sarah E. Seiler, Deborah M. Muoio, Robert C. Noland, Helen Lum, Robert Stevens, Fausto G. Hegardt
Publikováno v:
Journal of Biological Chemistry. 284:22840-22852
In addition to its essential role in permitting mitochondrial import and oxidation of long chain fatty acids, carnitine also functions as an acyl group acceptor that facilitates mitochondrial export of excess carbons in the form of acylcarnitines. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43769b289d9efe12b820ef3986bec6c6
https://doi.org/10.1074/jbc.m109.032888
https://doi.org/10.1074/jbc.m109.032888
Autor:
Eduardo López-Viñas, Gabriel Santpere, Fausto G. Hegardt, Paulino Gómez-Puertas, Sebastián Menao, Juan Pié, Adriana Y. Sierra, Patricia Carrasco, Josep Clotet, Esther Gratacós, Núria Casals, Beatriz Puisac
Publikováno v:
Molecular Genetics and Metabolism. 91:120-127
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase adopts a (betaalpha)(8) TIM barrel structure with an additional beta9, alpha11 and alpha12 helices. Location of HMG part of the substrate has been suggested but the binding mode for the CoA moiety remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46aed7c2238fea8a76205dcc92378663
https://doi.org/10.1016/j.ymgme.2007.03.007
https://doi.org/10.1016/j.ymgme.2007.03.007